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    HUMAN INKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS
    341.
    发明专利
    HUMAN INKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS 未知

    公开(公告)号：CA2923579A1

    公开(公告)日：2015-03-12

    申请号：CA2923579

    申请日：2014-09-08

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  YU ALICE L ,  LIN KUN-HSIEN ,  WU TAI-NA

    IPC: A61K39/39 ,  A61P35/00 ,  A61P37/04

    Abstract: Glycosphingolipids (GSLs) bearing a-glucose (a-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with a-glucose (a-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with a-galactose (a-Gal) are disclosed. GSLs bearing a-glucose (a-Glc) and derivatives of a-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with a-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with a-Glc and derivatives thereof are provided.

    Mehrachsige Aktorvorrichtung
    342.
    发明专利
    Mehrachsige Aktorvorrichtung 未知

    公开(公告)号：DE102012104749B4

    公开(公告)日：2015-02-12

    申请号：DE102012104749

    申请日：2012-06-01

    Applicant: ACADEMIA SINICA

    Inventor： HWANG ING-SHOU ,  HWU EN-TE

    IPC: G12B1/00 ,  G01Q10/00

    Abstract: Mehrachsige Aktorvorrichtung für eine Positionierungsvorrichtung, umfassend: ein bewegliches Element; einen Probentisch, der an dem beweglichen Element angebracht ist; eine Mehrzahl von Antriebselementen, die sich in einem reibschlüssigen Eingriff mit dem beweglichen Element befinden und ausgelegt sind, um das bewegliche Element wahlweise entlang einer ersten Richtung zu bewegen; und eine Mehrzahl von Aktoren, die die Mehrzahl von Antriebselementen bewegen, wenn an die Mehrzahl von Aktoren Ansteuersignale angelegt werden, wobei unterschiedliche Ansteuersignale an die Mehrzahl von Aktoren angelegt werden, um unterschiedliche Bewegungen der Antriebselemente zu bewirken, so dass das bewegliche Element unterschiedliche Verschiebungen entlang der Mehrzahl von Antriebselementen ausführt und aufgrund der unterschiedlichen Verschiebung verkippt wird.

    Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
    343.
    发明专利
    Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados 未知

    公开(公告)号：ES2442024T3

    公开(公告)日：2014-02-07

    申请号：ES09798721

    申请日：2009-07-15

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSENG SUSAN Y

    IPC: C40B40/12 ,  C40B50/14

    Abstract: Una matriz de carbohidratos inmovilizados en un sustrato sólido no transparente revestido con aluminio o unsustrato sólido no transparente revestido con aluminio polifluorado (de tipo politetrafluoroetileno (PTFE)),comprendiendo la matriz: una pluralidad de carbohidratos inmovilizados en localizaciones específicas en una superficie del sustrato sólidono transparente revestido con aluminio, de modo que: (a) los carbohidratos inmovilizados pueden caracterizarse por espectroscopia de masas (EM) y (b) puede realizarse análisis de reacciones de unión entre los carbohidratos y moléculas que se sospechaque se unen específicamente con los carbohidratos, donde el aluminio se usa para revestir un primer sustrato sólido transparente a un grosor mayor de 100 nm paraconvertir el primer sustrato sólido transparente en un sustrato sólido no transparente revestido con aluminio o unsustrato sólido no transparente revestido con aluminio de tipo PTFE polifluorado y donde la superficie del revestimiento de aluminio en el sustrato sólido se anodiza para formar una capa de óxidode aluminio porosa de un grosor menor de 5 nm.

    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES,ADJUVANTS,AND INTIVIRAL,ANTIBACTERIAL,AND ANTICANCER AGENTS
    344.
    发明专利
    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES,ADJUVANTS,AND INTIVIRAL,ANTIBACTERIAL,AND ANTICANCER AGENTS 未知

    公开(公告)号：ZA201101128B

    公开(公告)日：2013-11-27

    申请号：ZA201101128

    申请日：2011-02-11

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  HUNG JUNG-TUNG

    IPC: A61K20060101 ,  A61P20060101

    Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

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