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公开(公告)号：KR1020140043219A
公开(公告)日：2014-04-08
申请号：KR1020120107299
申请日：2012-09-26
Applicant: 강원대학교산학협력단 , 주식회사 두산에코비즈넷 , 서원대학교산학협력단
Abstract: The present invention relates to a method which prevents the low application stability of crops due to the excessive use of ethanol by enhancing the solubility of thiamine di-lauryl sulfate and is able to reduce the amount of thiamine di-lauryl sulfate used. A process of the present invention comprises: a dry nano-pulverizing step of pulverizing thiamine di-lauryl sulfate powders into a nano-size (1); a step of manufacturing a di-lauryl sulfate ethanol solution by spraying ethanol while spraying the manufacture thiamine di-lauryl sulfate nanoparticles through a nozzle (2); a di-lauryl sulfate solution manufacturing step of treating an ultrasonic process after adding distilled water in the thiamine di-lauryl sulfate ethanol solution (3); a step of consecutively irradiating visible rays through a pulse type laser while stirring the thiamine di-lauryl sulfate solution in order to have stability without the precipitation of the thiamine di-lauryl sulfate solution (4); and a step off adding tween80 which is a dispersant with functions forming a stable emulsion after the process (5). [Reference numerals] (AA) Manufacturing an aqueous solution capable of enhancing the solubility of TDS; (BB) Dry nanopulverizing pretreatment process; (CC) Pulverizing TDS through ultrafine vibration air; (DD) Compression strength: 34-37 kg.cm^2; (EE) Moisture content: 2-6%; (FF) Ultrasonic spraying process; (GG) Performing an ultrasonic process on a TDS ethanol solution in which TDS nanoparticles and ethanol are dissolved through a spraying nozzle; (HH) Spraying process: 100-150 g of TDS nanoparticels + 1 L of 40-60% ethanol; (II) Ultrasonic process: 10 ml of TDS ethanol solution + 4990 ml of distilled water; (JJ) Continuous pulse laser process; (KK) Irradiating pulse type laser; (LL) Pulse laser: 300 Mj, wavelength: 300-500 nm, Pulse width: 10 ns (FWHM), pulse repetition ratio:10 Hz; (MM) Adding 0.1-0.5% of a dispersant tween80 based on the whole volume when pulse laser is irradiated
Abstract translation: 本发明涉及通过提高硫代二月桂基硫酸硫胺素的溶解度而能够防止由于过量使用乙醇导致的农作物的低施用稳定性的方法，并且能够减少所用的二月桂基硫酸硫胺素的量。 本发明的方法包括：将二十二烷基硫酸硫胺素粉末粉碎成纳米尺寸（1）的干燥纳米粉碎步骤; 通过喷雾乙醇制造二月桂基硫酸盐乙醇溶液的步骤，同时通过喷嘴（2）喷洒生产的硫代二月桂基硫酸钠纳米颗粒; 在十二烷基硫酸硫胺素乙醇溶液（3）中加入蒸馏水后处理超声波处理的二月桂基硫酸盐溶液制造步骤; 在搅拌硫二胺二月桂基硫酸盐溶液的同时，通过脉冲式激光连续照射可见光以稳定而不沉淀硫代二月桂基硫酸盐溶液（4）的步骤; 并在步骤（5）之后加入吐温80，其为具有形成稳定乳液的功能的分散剂。 （附图标记）（AA）制造能够提高TDS溶解度的水溶液; （BB）干燥纳米粉末预处理工艺; （CC）通过超细振动空气粉碎TDS; （DD）抗压强度：34-37kg.cm ^ 2; （EE）水分含量：2-6％; （FF）超声波喷涂工艺; （GG）在TDS乙醇溶液中进行超声波处理，其中TDS纳米颗粒和乙醇通过喷嘴溶解; （HH）喷雾方法：100-150克TDS纳米颗粒+ 1升40-60％乙醇; （二）超声波处理：10ml TDS乙醇溶液+ 4990ml蒸馏水; （JJ）连续脉冲激光工艺; （KK）辐射脉冲激光器; （LL）脉冲激光：300Mj，波长：300-500nm，脉冲宽度：10ns（FWHM），脉冲重复比：10Hz; （MM）当脉冲激光照射时，基于整体积加入0.1-0.5％的分散剂tween80
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32.发明公开
公开(公告)号：KR1020140019185A
公开(公告)日：2014-02-14
申请号：KR1020120085912
申请日：2012-08-06
Applicant: 강원대학교산학협력단 , 서원대학교산학협력단
Abstract: The present invention relates to a cosmetic composition comprising Acer okamotoanum Nakai sap treated at an ultrahigh pressure and a manufacturing method thereof and more particularly, to Acer okamotoanum Nakai extract having anti-inflammatory effects and anti-atopic effects, which is treated at a low temperature of 25°C and a ultrahigh pressure of 300 to 500 MPa for 15 to 35 minutes, a functional cosmetic composition comprising the extract as an active ingredient and a manufacturing method thereof. The Acer okamotoanum Nakai extract treated at a low temperature and an ultrahigh pressure according to the present invention has enhanced storability because the growth of microorganisms contained in the extract is inhibited owing to the conducted ultrahigh pressure process, and reduces the loss and inactivity of useful bio-active substances contained in Acer okamotoanum Nakai, which is induced by a high temperature, owing to the treatment at a low temperature. Also the cosmetic composition comprising the Acer okamotoanum Nakai sap, which is manufactured by the method according to the present invention, as an active ingredient is safe in a long-term usage owing to the used natural materials and has no toxicity and no side effect. And the present invention can be useful in manufacturing functional cosmetics owing to the excellent effects of inhibiting inflammation and alleviating and treating atopy. [Reference numerals] (AA) Acer okamotoanum Nakai sap; (BB) Ultrahigh-pressure Acer okamotoanum Nakai sap; (CC) Acer mono sap; (DD) Ultrahigh-pressure Acer mono sap
Abstract translation: 本发明涉及一种包含在超高压下处理的中华猕猴桃汁和其制造方法的化妆品组合物，更具体地说，涉及具有抗炎作用和抗特应性作用的宏碁提取物，其在低温下处理 25℃，超高压300〜500MPa，15〜35分钟的功能化妆品组合物，其特征在于，含有提取物作为有效成分的功能性化妆品及其制造方法。 根据本发明处理的在低温和超高压下处理的Acer okamotoanum Nakai提取物具有增强的保存性，因为由于进行的超高压工艺，包含在提取物中的微生物的生长被抑制，并且减少了有用生物的损失和不活动 由于在低温下处理，由高温引起的Acer okamotoanum Nakai中含有的活性物质。 另外，通过本发明的方法制造的含有Acer okamotoanum Nakai sap的化妆品组合物作为活性成分，由于使用的天然材料而在长期使用中是安全的，并且没有毒性并且没有副作用。 本发明由于抑制炎症和减轻和治疗特应症的优异效果，可用于制造功能性化妆品。 [参考数字]（AA）Acer okamotoanum Nakai sap; （BB）超高压宏碁中ai汁; （CC）宏碁单汁液; （DD）超高压宏碁单汁液
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公开(公告)号：KR1020140016764A
公开(公告)日：2014-02-10
申请号：KR1020120084110
申请日：2012-07-31
Applicant: 강원대학교산학협력단 , 서원대학교산학협력단 , 주식회사 세바바이오텍
Abstract: The present invention relates to a high-functional cosmetic composition comprising coffee (coffee beans or by-products) fermented products and extracts thereof, and more particularly, to a high-functional cosmetic composition comprising, as active ingredients: a fermented liquor obtained fermenting coffee beans, which is not processed, by itself, or by-products of coffee, most of which are wasted not consumed, using lactobacillus strains; and residues of fermented coffee extracts obtained by performing ethanol extraction on the entire fermented coffee residues except the fermented liquor thereof. The coffee (coffee beans or by-products) fermented products and extracts thereof of the present invention is natural product-derived material and simultaneously display the effects of skin cell proliferation, antioxidant activities, moisturizing, wrinkle improvement, skin whitening and anti-inflammatory activities while stabilizing to the skin, such that the composition of the present invention can be effectively used as a high-functional cosmetic composition. Additionally, the coffee (coffee beans or by-products) fermented products and extracts thereof of the present invention can be manufactured through a simple process by utilizing coffee beans, having a low unit price, by itself or by-products of coffee wasted so as to have not only economical effects capable of reducing time, effort and costs but also eco-friendly effects through recycling of waste.
Abstract translation: 本发明涉及包含咖啡（咖啡豆或副产物）发酵产物及其提取物的高功能化妆品组合物，更具体地，涉及一种高功能化妆品组合物，其包含作为活性成分的发酵液：发酵咖啡 豆类本身或咖啡的副产物，其中大部分被浪费而不被消耗，使用乳杆菌属菌株; 以及通过在除发酵液以外的整个发酵咖啡残余物上进行乙醇提取而获得的发酵咖啡提取物的残留物。 本发明的咖啡（咖啡豆或副产品）发酵产物及其提取物是天然产物衍生物质，同时显示皮肤细胞增殖，抗氧化活性，保湿，皱纹改善，皮肤美白和抗炎活性的作用 同时稳定皮肤，使得本发明的组合物可以有效地用作高功能化妆品组合物。 此外，本发明的咖啡（咖啡豆或副产物）发酵产品及其提取物可以通过简单的方法通过使用具有低单位价格的咖啡豆或其自身的咖啡的副产物或者作为 不仅具有减少时间，精力和成本的经济效应，而且通过回收利用废物来实现环保效果。
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34.发明公开
公开(公告)号：KR1020120118326A
公开(公告)日：2012-10-26
申请号：KR1020110035821
申请日：2011-04-18
Applicant: 강원대학교산학협력단
IPC: A23L3/3472 , A23P1/02
CPC classification number: A23L3/3472 , A23L33/105 , A23V2200/10
Abstract: PURPOSE: A natural edible antimicrobial agent for food using the composite nanonization of a Japanese horseradish extract, and a producing method thereof are provided to reduce the unique smell of Japanese horseradish, and to maintain the quality of the food. CONSTITUTION: A producing method of a natural edible antimicrobial agent for food using the composite nanonization of a Japanese horseradish extract comprises the following steps: crushing Japanese horseradish, mixing the crushed Japanese horseradish with distilled water, tween-20, and homogenizing the mixture in a homogenizer; passing the obtained Japanese horseradish fluid through a micro-tube in the high pressure of 20,000-30,000psi for homogenizing the Japanese horseradish into the nano size; repeating the homogenizing process for 1-10 times; mixing and dissolving lecithin in a container with chloroform, and removing the chloroform using a decompressor to obtain multi-layers of the lecithin; inserting the Japanese horseradish fluid into the container with the multi-layers; and dispersing the Japanese horseradish fluid using ultrasonic waves for 30-40 minutes. [Reference numerals] (AA) Conventional single nanonization process; (BB) New complex nanonization process; (CC) Microfluidizer process: Japanese horseradish nanoparticles with the coagulating particles and Japanese horseradish smell; (DD) Homogenizer process: emulsified and homogenized Japanese horseradish samples; (EE) Ultrasonic dispersion process: Japanese horseradish nanoparticles with low collection rate, and unstable to the external environment; (FF) Microfluidizer process: homogenizing the Japanese horseradish nanoparticles; (GG) Japanese horseradish nanoparticles with low collection rate, and unstable to the external environment; (HH) Collecting the Japanese horseradish samples with lecithin for reducing the smell; (II) Japanese horseradish nanoparticles with high uniformity and collection rate, without the smell
Abstract translation: 目的：提供使用日本辣根提取物的复合纳米化的食品的天然可食用抗微生物剂及其制备方法，以减少日本辣根的独特气味，并保持食品的质量。 构成：使用日本辣根提取物的复合纳米化处理的食品天然可食用抗微生物剂的制造方法，包括以下步骤：粉碎日本辣根，将破碎的日本辣根与蒸馏水混合，tween-20，并将混合物均质化 均质; 将获得的日本辣根液通过20,000-3000psi的高压微管，使日本辣根均匀化成纳米尺寸; 重复匀浆过程1-10次; 将卵磷脂与氯仿混合溶解于容器中，用减压剂除去氯仿，得到多层卵磷脂; 将日本辣根流体用多层插入容器中; 并使用超声波将日本辣根分散液分散30-40分钟。 （标号）（AA）常规单纳米化方法; （BB）新的复合纳米化过程; （CC）微流化法：日本辣根纳米颗粒与凝结颗粒和日本辣根气味; （DD）均化器工艺：乳化均匀日本辣根样品; （EE）超声波分散工艺：采收率低的日本辣根纳米颗粒，对外界环境不稳定; （FF）微流化工艺：均化日本辣根纳米粒子; （GG）日本辣根纳米粒子，收集率低，对外部环境不稳定; （HH）采用卵磷脂收集日本辣根素，减少气味; （二）日本辣根纳米粒子具有高均匀性和收集率，无异味
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公开(公告)号：KR101158025B1
公开(公告)日：2012-06-26
申请号：KR1020100072261
申请日：2010-07-27
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 음료 첨가용 고로쇠 수액 분말의 제조방법과, 그 분말을 함유한 음료 및, 그 음료의 제조방법에 관한 것이다.
본 발명에서는 고로쇠 수액을 분말화함으로써 수액의 저장성과 유통기간 제한이라는 단점을 극복하였다. 또한 수액을 분말화 과정에서 적절한 부가재료를 첨가함으로써 수액에 함유된 당 성분으로 인해 분말화되기 어려운 난점을 해소하였으며, 결정과당을 첨가함으로써 향미도 및 감미도가 높아진 음료 제조가 가능하도록 하였다.
본 발명에 따르면 고로쇠 수액의 낮은 저장성과 유통기한의 한계를 극복하여 수액의 활용성을 확대할 수 있고, 이를 더덕이나 칡에 혼합함으로써 별도의 인공 감미료를 첨가하지 않고도 더덕이나 칡 특유의 향과 쓴맛을 보완하여 더덕이나 칡을, 그 고유의 기능을 발휘하는 음료로 활용되도록 할 수 있다.-
Patent Agency Ranking
公开(公告)号：KR1020120040126A
公开(公告)日：2012-04-26
申请号：KR1020117001159
申请日：2010-08-10
Applicant: 강원대학교산학협력단
CPC classification number: G01N1/4055 , G01N2001/4061
Abstract: PURPOSE: A method for measuring the concentration of bio ethanol in alcohol cultivating medium is provided to economically measure the concentration of bio ethanol based on a simple tool such as a micro tube and a 960deepwell microplate. CONSTITUTION: A method for measuring the concentration of bio ethanol in alcohol cultivating medium includes the following: ethanol is extracted from an alcohol cultivating medium using tri-n-butylphosphate as an extracting solvent; and the concentration of the extracted ethanol is measured based on a dichromate oxidation method. In the ethanol concentration measuring process using the dichromate oxidation method, the ethanol extract of the alcohol cultivating medium is reacted with dichromate reagent and the color change of the ethanol extract is compared to an ethanol standard graph.
Abstract translation: 目的：提供一种用于测量酒精培养基中生物乙醇浓度的方法，以经济测量生物乙醇的浓度为基础，采用简单的工具，如微管和960英尺微孔板。 构成：测定酒精栽培培养基中生物乙醇浓度的方法包括：使用三正丁基磷酸酯作为提取溶剂，从醇培养培养基中提取乙醇; 并且基于重铬酸盐氧化法测量提取的乙醇的浓度。 在使用重铬酸盐氧化法的乙醇浓度测定过程中，醇培养基的乙醇提取物与重铬酸盐试剂反应，并将乙醇提取物的颜色变化与乙醇标准图进行比较。
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公开(公告)号：KR1020110139407A
公开(公告)日：2011-12-29
申请号：KR1020100059484
申请日：2010-06-23
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A cosmetic composition containing mixture extract of Lithospermum erythrorhizon and Angelica gigas Nakai is provided to promote skin cell proliferation and to improve skin elasticity and moisturization. CONSTITUTION: A cosmetic composition for antiaging and whitening contains Lithospermum erythrorhizon and Angelica gigas Nakai extract as an active ingredient. The extract is stabilized with a nanoliposome. The nanoliposome is contained in 0.1-20 wt% based on total weight. A phospholipid for manufacturing the nanoliposome is lecithin. The nanoliposome is prepared by applying the mixture of Lithospermum erythrorhizon and Angelica gigas Nakai extract to an ultrasonic emitter at 32-42MHz for 30 minutes.
Abstract translation: 目的：提供含有紫草皂甙和当归黑containing的混合提取物的化妆品组合物，以促进皮肤细胞增殖，改善皮肤弹性和保湿。 构成：用于抗衰老和美白的化妆品组合物含有紫草红和当归提取物作为活性成分。 提取物用纳米脂质体稳定。 纳米脂质体以总重量计为0.1-20重量％。 用于制造纳米脂质体的磷脂是卵磷脂。 纳米脂质体通过将紫草紫草和当归提取物的混合物在32-42MHz的超声波发射器中施用30分钟来制备。
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公开(公告)号：KR1020110101657A
公开(公告)日：2011-09-16
申请号：KR1020100020818
申请日：2010-03-09
Applicant: 강원대학교산학협력단
IPC: A23G3/48
CPC classification number: A23G3/48 , A23G2200/14 , A23L33/105 , A23V2002/00 , A23V2200/25 , A23V2200/324
Abstract: 본 발명은 참당귀(
Angelica
gigas ) 수용성 추출물의 나노입자화를 이용한 소아용 면역 증진용 캔디류 제조방법에 관한 것이다.
본 발명에 따른, 참당귀 수용성 추출물의 나노입자화를 이용한 소아용 면역 증진용 캔디의 제조방법은, 젤라틴으로 참당귀의 열수추출물을 나노입자화하여 제조하는 것을 특징으로 한다.
본 발명에 따를 경우 나노입자화한 참당귀 추출물의 효과적인 세포 투과 기능으로 인해 적은 농도의 추출물로도 높은 활성을 기대할 수 있으므로 비용과 시간 면에서 경제적이다. 또한 쓴맛을 가지는 당귀를 젤라틴으로 포집하여 캔디로 만듦으로써 고유의 진한 냄새를 줄이고 향미를 증진시켜 어린이들도 쉽게 섭취할 수 있다.-
公开(公告)号：KR101479105B1
公开(公告)日：2015-01-07
申请号：KR1020120082332
申请日：2012-07-27
Applicant: 강원대학교산학협력단 , 서원대학교산학협력단 , 주식회사 세바바이오텍
IPC: A23L19/00 , A23L1/30 , A61K36/258 , A61K8/97
CPC classification number: A61K36/258 , A23L33/105 , A61K8/97 , A61K36/344 , A61K36/539 , A61K2236/39 , A61K2800/85 , A61Q19/00
Abstract: 본 발명은 동시 중온 추출 및 발효 공정을 이용하여 천연물 고유의 생리활성 물질 함량을 증진시키는 방법에 관한 것으로, 보다 구체적으로 본 발명은 천연물을 식용 가능한 호열성 균인 바실러스 코아귤란스(
Bacillus coagulans )을 이용하여 45~70℃에서 발효를 함에 있어서, 발효와 동시에 추출을 함으로써 기존의 발효를 통해 얻어지는 유용 생리활성 물질의 함량이 증진되며, 동시 추출 발효에 의해 전체적인 공정 소요 시간이 짧아져 경제적인 효과 또한 증가할 것으로 사료된다.
따라서 본 발명의 방법으로 동시 중온 추출 발효된 천연물으로부터 유용 생리활성 물질을 효과적으로 추출하여 생리활성 기능을 갖는 건강기능식품, 약학적 제제 및 화장품의 제조에 사용할 수 있는 효과가 있다.-
公开(公告)号：KR1020140140933A
公开(公告)日：2014-12-10
申请号：KR1020130061980
申请日：2013-05-30
Applicant: 서원대학교산학협력단 , 강원대학교산학협력단 , 주식회사 두산에코비즈넷
CPC classification number: A01N43/90 , A01N25/02 , A01N41/02 , A01N43/54 , A01N43/78 , B82Y30/00 , C07D417/06 , C07F9/10
Abstract: 본 발명은 비타민 B1 유도체인 티아민 다이-라우릴 설페이트(Thiamine di-laurly sulfate : TDS)의 나노 입자를 유효성분으로 포함하는 식물병 방제용 조성물 및 이의 제조방법에 관한 것으로, 본 발명에 따른 티아민 다이-라우릴 설페이트(Thiamine di-laurly sulfate : TDS)의 나노 입자는 100~200nm의 작은 입자크기를 가지며, 식물병 병원균에 대해 균사체 형성 이전인 균낭의 포자에 적용하여 상기 포자를 효과적으로 사멸시킬 수 있는 활성을 가지므로 식물병 방제를 위한 용도로 유용하게 사용할 수 있다.
Abstract translation: 本发明涉及含有作为维生素B1衍生物的活性成分的二月桂基硫酸硫胺素（TDS）纳米粒子的植物病害防治用组合物及其制造方法。 根据本发明的TDS纳米颗粒具有100-200nm的小粒径，并且可以应用于作为植物病原菌的菌丝体的前一步骤的霉菌的孢子以有效地杀死孢子，从而可用于控制 植物病害。
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