公开(公告)号：DK59991D0

公开(公告)日：1991-04-04

申请号：DK59991

申请日：1991-04-04

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  BOYD STEVEN A ,  KEMPF DALE J ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07C237/20 ,  C07D205/04 ,  C07D233/64 ,  C07D295/182 ,  C07D405/12 ,  C07K5/06

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

公开(公告)号：AU4416389A

公开(公告)日：1990-05-01

申请号：AU4416389

申请日：1989-10-03

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  BAKER WILLIAM R ,  ARMIGER YOEK-LIN ,  ROSENBERG SAUL H ,  DE BISWANATH ,  PLATTNER JACOB J ,  BOYD STEVEN A ,  KEMPE DALE J ,  SHAM HING LEUNG ,  KLEINERT HOLLIS D ,  MANTEI ROBERT A

IPC: A61K31/16 ,  A61K31/19 ,  A61K31/265 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/66 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C237/22 ,  C07C317/28 ,  C07C323/57 ,  C07C323/58 ,  C07D203/18 ,  C07D211/44 ,  C07D211/46 ,  C07D211/62 ,  C07D211/96 ,  C07D233/36 ,  C07D233/54 ,  C07D233/56 ,  C07D263/22 ,  C07D295/185 ,  C07D401/12 ,  C07D407/12 ,  C07D413/12 ,  C07D521/00 ,  C07D211/48

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; R1 is hydrogen, loweralkyl, substituted loweralkyl or loweralkenyl; X is CH2, CHOH, C(O), O, S, S(O), SO2, NH, N(O) or -P(O)O-; R3 is loweralkyl, loweralkenyl or substituted loweralkyl; and T is mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

公开(公告)号：AU3566089A

公开(公告)日：1989-11-29

申请号：AU3566089

申请日：1989-05-12

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  PLATTNER JACOB J ,  NORBECK DANIEL W ,  BOYD STEVEN A ,  BAKER WILLIAM R ,  ERICKSON JOHN W ,  CROWLEY STEVEN R ,  FUNG ANTHONY K L

IPC: A61K31/16 ,  A61K31/275 ,  A61K31/335 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/405 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/44 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/54 ,  A61K38/00 ,  A61K38/55 ,  A61P31/12 ,  A61P43/00 ,  C07C233/36 ,  C07C233/47 ,  C07C235/10 ,  C07C235/12 ,  C07C237/10 ,  C07C237/12 ,  C07C237/22 ,  C07C271/22 ,  C07C317/44 ,  C07C323/60 ,  C07D207/12 ,  C07D207/337 ,  C07D213/81 ,  C07D231/12 ,  C07D233/32 ,  C07D233/36 ,  C07D233/64 ,  C07D239/04 ,  C07D239/10 ,  C07D257/04 ,  C07D263/06 ,  C07D263/16 ,  C07D263/20 ,  C07D263/22 ,  C07D263/24 ,  C07D263/26 ,  C07D265/06 ,  C07D265/10 ,  C07D271/10 ,  C07D273/00 ,  C07D277/28 ,  C07D277/64 ,  C07D277/66 ,  C07D295/20 ,  C07D295/205 ,  C07D295/215 ,  C07D307/14 ,  C07D307/28 ,  C07D307/58 ,  C07D307/68 ,  C07D309/04 ,  C07D309/20 ,  C07D317/34 ,  C07D317/36 ,  C07D333/38 ,  C07D407/04 ,  C07D413/04 ,  C07D413/06 ,  C07K5/06 ,  C07K5/065 ,  C07K5/103 ,  C07K5/107 ,  C07K7/02 ,  A61K37/02 ,  C07K7/06 ,  C07K7/08 ,  C07K7/10

公开(公告)号：AU1158088A

公开(公告)日：1988-07-27

申请号：AU1158088

申请日：1987-12-22

Applicant: ABBOTT LAB

Inventor： PLATTNER JACOB JOHN ,  ROSENBERG SAUL HOWARD ,  LULY JAY RICHARD ,  KEMPF DALE JOHN ,  FUNG ANTHONY K L

IPC: C12N9/99 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  A61K38/00 ,  A61P9/12 ,  C07C67/00 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/34 ,  C07C235/74 ,  C07C235/78 ,  C07C237/06 ,  C07C237/08 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/00 ,  C07C271/20 ,  C07C271/24 ,  C07C313/00 ,  C07C317/44 ,  C07C323/60 ,  C07C325/00 ,  C07C327/20 ,  C07C333/02 ,  C07D213/00 ,  C07D213/71 ,  C07D213/78 ,  C07D233/54 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/083 ,  C07K5/097 ,  C07K14/81 ,  C07K5/10 ,  A61K37/43

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, (alpha,alpha)-dimethylbenzyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R2 is hydrogen or loweralkyl; R3 is loweralkenyl, [(alkoxy)alkoxy]alkyl, (thioalkoxy)alkyl, lowerakenyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is vinyl, formyl, hydroxymethyl or hydrogen; R7 is hydrogen or loweralkyl; R8 and R9 are independently selected from OH and NH2; and R6 is hydrogen, loweralkyl, vinyl or arylalkyl; provided that when R5 and R7 are both hydrogen and R8 and R9 are OH, the carbon bearing R5 is of the "R" configuration and the carbon bearing R6 is of the "S" configuration, or pharmaceutically acceptable salts or esters thereof. Also disclosed are renin inhibiting compositions, a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.

公开(公告)号：CA1096772A

公开(公告)日：1981-03-03

申请号：CA289660

申请日：1977-10-27

Applicant: ABBOTT LAB

Inventor： STEIN HERMAN H ,  PRASAD RAJ N ,  TIETJE KARIN R ,  FUNG ANTHONY K L

IPC: C07H19/16 ,  A01N9/22

Abstract: ADENOSINE-5'-CARBOXAMIDES A method of controlling undesired animals including rodents, coyotes and birds which comprises making available to said animals an edible composition containing, as the active ingredient, a lethal dose of a compound represented by formula or (1) (2) wherein R is H, loweralkyl or acetyl; R1 is H or acetyl; R2 is H, Cl or NH2; R3 is H, loweralkyl, alkoxy, cycloalkyl or hydroxyalkyl; R4 and R5 are each H, acetyl or propionyl, or when taken together form a p-chlorobenzylidene, a carbonate or an ethoxymethylene moiety; in a suitable carrier.

公开(公告)号：CA1027575A

公开(公告)日：1978-03-07

申请号：CA219765

申请日：1975-02-11

Applicant: ABBOTT LAB

Inventor： BIEL JOHN H ,  BARIANA DILBAGH S ,  FUNG ANTHONY K L

IPC: C07D409/12 ,  A61K31/41 ,  A61P7/10 ,  A61P9/12 ,  C07D333/22

Abstract: The present invention provides a therapeutically active composition having uricosuric, diuretic and antihypertension properties. The composition contains, as its active ingredient, a tetrazole compound having the structural formula: