公开(公告)号：AU724353B2

公开(公告)日：2000-09-21

申请号：AU6271898

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：PL335373A1

公开(公告)日：2000-04-25

申请号：PL33537398

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：GR3031939T3

公开(公告)日：2000-03-31

申请号：GR990403031

申请日：1999-11-25

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：SK115299A3

公开(公告)日：2000-01-18

申请号：SK115299

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：NO994108L

公开(公告)日：1999-10-25

申请号：NO994108

申请日：1999-08-25

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：AT183993T

公开(公告)日：1999-09-15

申请号：AT94929340

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：NO994108D0

公开(公告)日：1999-08-25

申请号：NO994108

申请日：1999-08-25

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02 ,  C07D

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：HK1011677A1

公开(公告)日：1999-07-16

申请号：HK98112593

申请日：1998-11-30

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA ROBERT M ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14 ,  C07C

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：AU6271898A

公开(公告)日：1998-09-18

申请号：AU6271898

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：AU5181590A

公开(公告)日：1990-09-26

申请号：AU5181590

申请日：1990-02-06

Applicant: ABBOTT LAB

Inventor： BROOKS DEE W ,  KERDESKY FRANCIS A J ,  HOLMS JAMES H

IPC: C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61P1/00 ,  A61P11/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D277/34 ,  C07D277/54 ,  C07D277/64 ,  C07D417/04 ,  C07D233/32

Abstract: A composition for the inhibition of lipoxygenase enzymes comprising a pharmaceutically acceptable carrier and a compound of the formula: I wherein R1 and R2 are independently selected from the group consisting of alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, arylalkenyl, reduced heteroaryl, and reduced heteroarylalkyl and substituted derivatives thereof having one or more substituents independently selected from the group consisting of halogen, alkyl, halosubstituted alkyl, aryl, arylalkyl, reduced heteroaryl, arylalkoxy, cyano, nitro, COR4, SO2R4, NR5R6, OR6, COCX1X2NR6R7, CON(OH)R6, NR6COR4, CR5(NH2)CO2R5, NHCX1X2CO2R5, N(OH)CONR5R6, N(OH)COR4, NHCONR5R6, C(NOH)NHOH and CONHNR5R6; R3 is selected from the group consisting of hydrogen, a pharmaceutically acceptable salt, COR4, COCX1X2NR6R7, CR8R9OR10, CH2CR8(OR10)CH2OR11 and SiR12R13R14; R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced heteroaryl, reduced heteroarylalkyl, OR5, NHCX1X2CO2R5 and NR6R7; R5 is selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, aryl, arylalkyl, reduced heteroaryl, and reduced heteroarylalkyl; R6 and R7 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, aryl, arylalkyl, reduced heteroaryl, reduced heteroarylalkyl and (CH2)nOR5 where n is 2-4 and R5 is as defined above; R8, R9, R10 and R11 are independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl and (CH2)nOR5 or at least two of R8, R9, R10 and R11 together form a ring system containing 5-10 atoms wherein said ring system is carbocyclic, heterocyclic or reduced heterocyclic and R5 and n are as defined above; R12, R13 and R14 are independently selected from the group consisting of alkyl and aryl; and X1 and X2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, cycloalkyl, aryl, and arylalkyl; and the acid addition salts thereof.