Patent search ap:("ABBOTT LAB") AND inv:"HOLMS JAMES H" Page 1

1.

发明申请
9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES 审中-公开
Title translation: 作为蛋白激酶的抑制剂的9组分的杂环化合物

公开(公告)号：WO2007067781A3

公开(公告)日：2007-07-26

申请号：PCT/US2006047078

申请日：2006-12-08

Applicant: ABBOTT LAB , MICHAELIDES MICHAEL R , MCCLELLAN WILLIAM J , FREY ROBIN R , CURTIN MICHAEL L , STEINMAN DOUGLAS H , DAI YUJIA , HOLMS JAMES H

Inventor： MICHAELIDES MICHAEL R , MCCLELLAN WILLIAM J , FREY ROBIN R , CURTIN MICHAEL L , STEINMAN DOUGLAS H , DAI YUJIA , HOLMS JAMES H

IPC: C07D487/04 , A61K31/519 , A61P35/00 , C07D495/04

CPC classification number: C07F9/6561 , C07D487/04 , C07D495/04

Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating cancer using the compounds are disclosed.

Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗癌症的方法。

2.

发明申请
N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES 审中-公开
Title translation: 作为基质金属蛋白酶抑制剂的N-羟基甲酰胺衍生物

公开(公告)号：WO9906361A3

公开(公告)日：1999-04-22

申请号：PCT/US9815486

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F JR , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG

IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/16 , A61K31/415

CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

Abstract translation: 具有式（I）的化合物是基质金属蛋白酶抑制剂。还公开了抑制哺乳动物基质金属蛋白酶的基质金属蛋白酶抑制组合物和抑制基质金属蛋白酶的方法。

3.

发明申请
INHIBITORS OF HISTONE DEACETYLASE 审中-公开
Title translation: HISTONE DEACETYLASE的抑制剂

公开(公告)号：WO0246129A3

公开(公告)日：2003-01-16

申请号：PCT/US0150931

申请日：2001-10-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L , DAI YUJIA , DAVIDSEN STEVEN K , FREY ROBIN R , GUO YAN , HEYMAN HOWARD R , HOLMS JAMES H , JI ZHIQIN , MICHAELIDES MICHAEL R , VASUDEVAN ANIL , WADA CAROL K

IPC: C07C45/29 , C07C45/30 , C07C45/45 , C07C45/51 , C07C45/67 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07D209/08 , C07D209/42 , C07D213/30 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10 , C07D295/10

CPC classification number: C07D213/30 , C07C45/29 , C07C45/30 , C07C45/45 , C07C45/515 , C07C45/673 , C07C47/277 , C07C49/255 , C07C59/90 , C07C69/716 , C07C235/14 , C07C235/16 , C07C235/20 , C07C235/74 , C07C235/80 , C07C243/38 , C07C255/54 , C07C255/60 , C07C311/19 , C07C317/32 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/14 , C07C2603/18 , C07C2603/74 , C07D209/08 , C07D209/42 , C07D213/40 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/06 , C07D257/04 , C07D263/14 , C07D263/32 , C07D263/58 , C07D271/10 , C07D277/46 , C07D277/56 , C07D277/74 , C07D277/82 , C07D285/08 , C07D295/112 , C07D307/68 , C07D307/85 , C07D317/58 , C07D317/66 , C07D317/68 , C07D413/04 , C07D413/12 , C07D417/04 , C07D491/10

Abstract: Compounds having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.

Abstract translation: 具有式或其治疗上可接受的盐的化合物是组蛋白脱乙酰酶（HDAC）抑制剂。公开了化合物的制备，含有该化合物的组合物以及使用该化合物治疗疾病。

4.

发明公开
PLATELET ACTIVATING FACTOR ANTAGONISTS 失效
Title translation: PLATELET激活因子拮抗剂

公开(公告)号：EP0595924A4

公开(公告)日：1994-08-24

申请号：EP92915895

申请日：1992-07-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B , DAVIDSEN STEVEN K , HOLMS JAMES H , PIREH DAISY , HEYMAN H ROBIN , MARTIN MICHAEL B , STEINMAN DOUGLAS H , SHEPPARD GEORGE S , CARRERA GEORGE M JR

IPC: A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00

CPC classification number: C07D487/04 , A61K49/06 , C07D213/69 , C07D513/04

5.

发明专利
REVERSE HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES 未知

公开(公告)号：CA2358951C

公开(公告)日：2009-10-20

申请号：CA2358951

申请日：2000-01-27

Applicant: ABBOTT LAB

Inventor： STEINMAN DOUGLAS H , DAVIDSEN STEVEN K , DAI YUJIA , MICHAELIDES MICHAEL R , CURTIN MICHAEL L , HEYMAN HOWARD R , HOLMS JAMES H

IPC: C07D317/28 , A61K31/335 , A61K31/341 , A61K31/357 , A61K31/40 , A61K31/421 , A61P1/02 , A61P1/04 , A61P17/02 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D207/09 , C07D207/14 , C07D207/48 , C07D263/04 , C07D307/14

Abstract: Compounds having formula (I) are matric metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

6.

发明专利
未知

公开(公告)号：DE69809924T2

公开(公告)日：2003-08-21

申请号：DE69809924

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L , DAVIDSEN STEVEN K , DELLARIA JOSEPH F , FLORJANCIC ALAN S , GIESLER JAMIE , GONG JIANCHUN , GUO YAN , HEYMAN H ROBIN , HOLMS JAMES H , MICHAELIDES MICHAEL R , STEINMAN DOUGLAS H , WADA CAROL K , XU LIANHONG

IPC: C07D233/74 , A61K31/275 , A61K31/351 , A61K31/352 , A61K31/4035 , A61K31/4166 , A61K31/4178 , A61K31/421 , A61K31/428 , A61K31/4439 , A61K31/4465 , A61K31/45 , A61K31/454 , A61K31/50 , A61P1/02 , A61P1/04 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07C259/06 , C07C311/05 , C07C311/18 , C07C317/28 , C07C317/40 , C07C323/47 , C07C323/62 , C07D207/40 , C07D207/404 , C07D207/416 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/04 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07C259/00

Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.

7.

发明专利
未知

公开(公告)号：DK0874808T3

公开(公告)日：2003-08-04

申请号：DK96940406

申请日：1996-11-13

Applicant: ABBOTT LAB

Inventor： FESIK STEPHEN W , SUMMERS JAMES B JR , DAVIDSEN STEVEN K , SHEPPARD GEORGE S , STEINMAN DOUGLAS H , CARRERA GEORGE M JR , FLORJANCIC ALAN , HOLMS JAMES H

IPC: A61P19/02 , A61K31/185 , A61K31/275 , A61P29/00 , A61P35/04 , A61P43/00 , C07C259/06 , C07C323/60 , A61K31/16

Abstract: Compounds of formula or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF alpha secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF alpha secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF alpha secretion.