公开(公告)号：JP2006206597A

公开(公告)日：2006-08-10

申请号：JP2006052376

申请日：2006-02-28

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C215/28 ,  C07B61/00 ,  C07C213/00 ,  C07C225/14 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/38 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

CPC classification number: C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

Abstract: PROBLEM TO BE SOLVED: To provide a substituted 2,5-diamino-3-hydroxyhexane useful for producing HIV protease inhibitors, and to provide a method for producing the compound.
SOLUTION: The substituted 2,5-diamino-3-hydroxyhexane useful for producing HIV protease inhibitors is represented by general formula I.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供可用于产生HIV蛋白酶抑制剂的取代的2,5-二氨基-3-羟基己烷，并提供一种生产该化合物的方法。 解决方案：用于生产HIV蛋白酶抑制剂的取代的2,5-二氨基-3-羟基己烷由通式I表示。（C）2006，JPO和NCIPI

公开(公告)号：WO2006019660A3

公开(公告)日：2006-05-11

申请号：PCT/US2005024447

申请日：2005-07-08

Applicant: ABBOTT LAB ,  BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

Inventor： BUCKLEY MICHAEL J ,  JI JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LI WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: C07D487/04 ,  A61K31/4439

CPC classification number: C07D487/04

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

Abstract translation: 本发明公开了（1S，5S）-3-（5,6-二氯-3-吡啶基）-3,6-二氮杂双环[3.2.0]庚烷及其盐，其用于治疗与 烟碱乙酰胆碱受体。

公开(公告)号：WO2005012273A3

公开(公告)日：2005-05-12

申请号：PCT/US2004024758

申请日：2004-07-30

Applicant: ABBOTT LAB ,  ROBBINS TIMOTHY A ,  ZHU HELEN ,  SHAO JUN

Inventor： ROBBINS TIMOTHY A ,  ZHU HELEN ,  SHAO JUN

IPC: C07D277/56

CPC classification number: C07D277/56

Abstract: This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

Abstract translation: 本发明涉及制备取代噻唑的方法。 取代的噻唑，2-（4-羟基苯基）-4-甲基-1,3-噻唑-5-羧酸乙酯，也称为TEI-6720，可用于治疗痛风和高尿酸血症。 该化合物属于一类可抑制黄嘌呤氧化酶并因此阻断尿酸生产的取代噻唑类。

公开(公告)号：NZ552520A

公开(公告)日：2010-09-30

申请号：NZ55252005

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： BUCKLEY MICHAEL J ,  JL JIANGUO ,  ZHANG GEOFF G ,  HENRY RODGER F ,  WANG WEILI W ,  WAYNE GREG S ,  LL WENKE ,  TOWNE TIMOTHY B ,  WITTENBERGER STEVEN J ,  HANNICK STEVEN M ,  KOTECKI BRIAN J ,  MARCI BRYAN S ,  ROBBINS TIMOTHY A

IPC: A61K31/4439 ,  C07D487/04

Abstract: Disclosed is a salt of (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, selected from the group consisting of acetate, citrate, fumarate, hemicitrate, hydrocholoride, maleate, methanesulfonate, 4-methylbenzenesulfonate, sulphate, L-tartrate and trifluoroacetate. Also disclosed is a process for preparing a compound of formula (5J) comprising the steps of a) treating compound (5D), with an aqueous acid; b) treating the mixture from step (a) with a compound of formula (A), wherein R2 is phenyl optionally substituted with alkyl, alkoxy or halo in the presence of magnesium bromide in a mixture of isopropyl alcohol and dichloromethane to provide a compound of formula (B), c) using the compound of formula (B) to prepare the compound (5J).

公开(公告)号：DK0916646T3

公开(公告)日：2003-08-25

申请号：DK99101692

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： KERDESKY FRANCIS A J ,  NORBECK DANIEL W ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  STUK TIMOTHY L ,  LIJEWSKI-LINCH LINDA M ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：GR3032553T3

公开(公告)日：2000-05-31

申请号：GR20000400249

申请日：2000-02-02

Applicant: ABBOTT LAB

Inventor： HAIGHT ANTHONY R ,  GOODMONSON OWEN J ,  PAREKH SHYAMAL I ,  ROBBINS TIMOTHY A ,  SEIF LOUIS S

IPC: B01J23/42 ,  B01J31/06 ,  B01J32/00 ,  C07B61/00 ,  C07C213/00 ,  C07C215/28 ,  C07C215/32 ,  C07C213/08

公开(公告)号：CA2533658C

公开(公告)日：2013-10-22

申请号：CA2533658

申请日：2004-07-30

Applicant: ABBOTT LAB

Inventor： ROBBINS TIMOTHY A ,  ZHU HELEN ,  SHAO JUN

IPC: C07D277/56

Abstract: This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

公开(公告)号：AU2005275387A1

公开(公告)日：2006-02-23

申请号：AU2005275387

申请日：2005-07-08

Applicant: ABBOTT LAB

Inventor： KOTECKI BRIAN J ,  JI JIANGUO ,  LI WENKE ,  HANNICK STEVEN M ,  ZHANG GEOFF G ,  WAYNE GREG S ,  ROBBINS TIMOTHY A ,  BUCKLEY MICHAEL J ,  WANG WEILI W ,  WITTENBERGER STEVEN J ,  HENRY RODGER F ,  MARCI BRYAN S ,  TOWNE TIMOTHY B

IPC: C07D487/04 ,  A61K31/4439

Abstract: The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic acetylcholine receptor.

公开(公告)号：CA2174000C

公开(公告)日：2005-05-24

申请号：CA2174000

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK TIMOTHY L ,  KERDESKY FRANCIS A J ,  LIJEWSKI LINDA M ,  NORBECK DANIEL W ,  SCARPETTI DAVID ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  LANGRIDGE DENTON C ,  MELCHER LAURA ,  RENO DANIEL S ,  SHAM HING LEUNG ,  ZHAO CHEN ,  HAIGHT ANTHONY R ,  LEANNA M ROBERT ,  MORTON HOWARD E ,  ROBBINS TIMOTHY A ,  SOWIN THOMAS J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14 ,  C07C233/36 ,  C07C217/58 ,  C07C233/78

Abstract: Intermediates and processes are disclosed which are useful for the preparati on of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd a nd Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected fr om loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken togethe r with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independent ly selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：AT187160T

公开(公告)日：1999-12-15

申请号：AT95926318

申请日：1995-07-17

Applicant: ABBOTT LAB

Inventor： HAIGHT ANTHONY R ,  GOODMONSON OWEN J ,  PAREKH SHYAMAL I ,  ROBBINS TIMOTHY A ,  SEIF LOUIS S

IPC: B01J23/42 ,  B01J31/06 ,  B01J32/00 ,  C07B61/00 ,  C07C213/00 ,  C07C215/28 ,  C07C215/32 ,  C07C213/08