公开(公告)号：ES2196548T3

公开(公告)日：2003-12-16

申请号：ES98907359

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：NZ515207A

公开(公告)日：2003-09-26

申请号：NZ51520700

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  DAANEN JEROME F ,  RYTHER KEITH B ,  JI JIANGUO

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04

Abstract: A compound of formula I (Z-R3) or pharmaceutically acceptable salts where: Z is selected from the group consisting of formulae labeled 'Z'. R1 and R2 are independently selected from the group consisting of hydrogen and alkyl; A and B are independently absent or independently selected from the group consisting of alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkynyl, carboxy, haloalkyl, halogen, hydroxy, and hydroxyalkyl; R3 is selected from the group consisting of formulae labeled 'R3' R4 is selected from the group consisting of hydrogen, alkyl, and halogen; R5 is selected from the group consisting of hydrogen, alkoxy, alkyl, halogen, nitro, and -NR10R11 wherein R10 and R11 are independently selected from the group consisting of hydrogen and lower alkyl; R6 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylthio, alkynyl, amino, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, aminosulfonyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, 5-tetrazolyl,-NR7SO2R8, -C (NR7) NR8R9,-CH2C (NR7) NR8R9,-C (NOR7) R8,-C (NCN) R7,-C (NNR7R8) R9,-S (O) 2OR7, and-S (O) 2R7; and R7, R8, and R9 are independently selected from the group consisting of hydrogen and alkyl. The compound of formula I may be used to treat Alzheimer's disease, Parkinson's disease, attention deficit hyperactivity disorder, depression, nicotinic withdrawal syndrome, Tourette's syndrome, and schizophrenia. It may also be used as an analgesic.

公开(公告)号：AT237618T

公开(公告)日：2003-05-15

申请号：AT98907359

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44 ,  C07D209/00

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：ZA200105835B

公开(公告)日：2002-10-16

申请号：ZA200105835

申请日：2001-07-16

Applicant: ABBOTT LAB

Inventor： BUNNELLE WILLIAM H ,  DAANEN JEROME F ,  MEYER MICHAEL D ,  SCHRIMPF MICHAEL R ,  TOUPENCE RICHARD B ,  CRISTINA DANIELA BARLOCCO ,  DART MICHAEL J ,  RYTHER KEITH B ,  SIPPY KEVIN B

IPC: A61K31/00 ,  A61K31/407 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D401/08 ,  C07D471/08 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  C07D ,  A61K ,  A61P

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：BR0007229A

公开(公告)日：2002-09-10

申请号：BR0007229

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  DAANEN JEROME F ,  RYTHER KEITH B ,  JI JIANGUO

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：NO20015669L

公开(公告)日：2001-11-23

申请号：NO20015669

申请日：2001-11-20

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  DAANEN JEROME F ,  JI JIANGUO ,  SIPPY KEVIN B ,  RYTHER KEITH B

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：NO20015669D0

公开(公告)日：2001-11-20

申请号：NO20015669

申请日：2001-11-20

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  DAANEN JEROME F ,  JI JIANGUO ,  SIPPY KEVIN B ,  RYTHER KEITH B

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04 ,  C07D

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：CZ20012716A3

公开(公告)日：2001-11-14

申请号：CZ20012716

申请日：2000-01-25

Applicant: ABBOTT LAB

Inventor： BUNNELLE WILLIAM H ,  CTISTINA DANIELLA BARLOCCO ,  DAANEN JEROME F ,  DART MICHAEL J ,  MEYER MICHAEL D ,  RYTHER KEITH B ,  SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  TOUPENCE RICHARD B

IPC: A61K31/00 ,  A61K31/407 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D401/08 ,  C07D471/08 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/395 ,  C07D241/00 ,  C07D209/00 ,  C07D221/00

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：AT200084T

公开(公告)日：2001-04-15

申请号：AT96926133

申请日：1996-07-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT RICHARD L ,  RYTHER KEITH B ,  HOLLADAY MARK W ,  WASICAK JAMES T ,  DAANEN JEROME F

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/4355 ,  A61P9/00 ,  A61P25/00 ,  A61P25/30 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  C07D307/00 ,  C07D221/00

Abstract: Novel heterocyclic ether compounds having the formula: wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：BG103556A

公开(公告)日：2000-06-30

申请号：BG10355699

申请日：1999-07-06

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT S ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRICH PAUL P

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The invention relates to a method for pain control in mammals, including humans where selected compounds are applied with the formula or their pharmaceutically acceptable salts, the meaning of the substituents being listed in the description. The invention also relates to selected (R) and (S) compounds with formula I which can be used as analgetics, as means for the prevention of dying of neuron cells and as antiphlogistic preparations. 38 claims, 7 figures