公开(公告)号：CA2682231A1

公开(公告)日：2008-10-09

申请号：CA2682231

申请日：2008-03-27

Applicant: ARRAY BIOPHARMA INC

Inventor： MARMSAETER FREDRIK P ,  RIZZI JAMES P ,  ROBINSON JOHN E ,  LYSSIKATOS JOSEPH P ,  MUNSON MARK C ,  ZHAO QIAN ,  TOPALOV GEORGE T ,  SCHLACHTER STEPHEN T

IPC: C07D471/04 ,  A61K31/4709 ,  A61P35/00

Abstract: Compounds of Formula (I): are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class (3) and class (5) receptor tyrosine kinases. Particular compounds of this invention have also been found to be i nhibitors of Pim-1.

公开(公告)号：CA2785338C

公开(公告)日：2018-09-18

申请号：CA2785338

申请日：2010-12-20

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL ,  DELISLE ROBERT KIRK ,  HENNINGS D DAVID ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW ,  MUNSON MARK C ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D519/00

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain. (see formula I)

公开(公告)号：AU2018201903A1

公开(公告)日：2018-04-12

申请号：AU2018201903

申请日：2018-03-16

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: [007801 Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R', R2, R, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：AU2016222468B2

公开(公告)日：2017-12-21

申请号：AU2016222468

申请日：2016-09-02

Applicant: ARRAY BIOPHARMA INC

Inventor： ZHAO QIAN ,  NEWHOUSE BRAD ,  DELISLE ROBERT KIRK ,  RAST BRYSON ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  TOPALOV GEORGE T ,  RIZZI JAMES P ,  BOYS MARK LAURENCE ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  RODRIGUEZ MARTHA E

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2 , R3 , R4, R' and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：PL2651939T3

公开(公告)日：2015-10-30

申请号：PL11808427

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：SMT201500165B

公开(公告)日：2015-09-07

申请号：SM201500165

申请日：2015-07-08

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  KENNEDY APRIL L ,  MUNSON MARK C ,  RAST BRYSON ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN ,  HICKEN ERIK JAMES ,  MARMSATER FREDRIK P ,  MARESKA DAVIDE A ,  NEWHOUSE BRAD ,  RIZZI JAMES P

Abstract: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

公开(公告)号：SI2651939T1

公开(公告)日：2015-07-31

申请号：SI201130508

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/00 ,  A61K31/00 ,  A61P35/00

公开(公告)号：DK2651939T3

公开(公告)日：2015-06-01

申请号：DK11808427

申请日：2011-12-13

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  DELISLE ROBERT KIRK ,  HICKEN ERIK JAMES ,  KENNEDY APRIL L ,  MARESKA DAVID A ,  MARMSATER FREDRIK P ,  MUNSON MARK C ,  NEWHOUSE BRAD ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：AU2010333752B2

公开(公告)日：2014-12-04

申请号：AU2010333752

申请日：2010-12-20

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL F ,  DELISLE ROBERT KIRK ,  HENNINGS D DAVID ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW DAVID ,  MUNSON MARK C ,  RAST BRYSON ,  RIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/08 ,  A61P29/00 ,  A61P35/00 ,  C07D519/00

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R

公开(公告)号：SMT201400142B

公开(公告)日：2014-11-10

申请号：SM201400142

申请日：2014-09-30

Applicant: ARRAY BIOPHARMA INC

Inventor： BOYS MARK LAURENCE ,  BRADLEY MICHAEL F ,  DELISLE ROBERT KIRK ,  HENNINGS DAVID D ,  KENNEDY APRIL L ,  MARMSATER FREDRIK P ,  MEDINA MATTHEW DAVID ,  MUNSON MARK C ,  RAST BRYSON ,  PIZZI JAMES P ,  RODRIGUEZ MARTHA E ,  TOPALOV GEORGE T ,  ZHAO QIAN

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.