公开(公告)号：HUT46946A

公开(公告)日：1988-12-28

申请号：HU242888

申请日：1988-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  HILLEN HEINZ ,  EMLING FRANZ ,  MOELLER ACHIM ,  KEILHAUER GERHARD ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C12N15/00

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：AU1615188A

公开(公告)日：1988-11-17

申请号：AU1615188

申请日：1988-05-13

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C12N15/00 ,  C07K13/00 ,  A61K37/02 ,  A61K37/43

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：DK587688D0

公开(公告)日：1988-10-21

申请号：DK587688

申请日：1988-10-21

Applicant: BASF AG

Inventor： KOERWER WOLFGANG ,  KURFUERST MANFRED ,  BALDINGER VERENA ,  DOERPER THOMAS ,  SCHWARZ MARGARETE

IPC: A61K38/46 ,  A61P7/02 ,  C07K14/00 ,  C12N9/72 ,  C12N15/00 ,  C12N15/09 ,  C12R1/19 ,  C12R1/91 ,  C07K13/00 ,  C07H21/04

公开(公告)号：ES2063350T3

公开(公告)日：1995-01-01

申请号：ES90906924

申请日：1990-05-04

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18 ,  C07K15/14 ,  A61K35/12

Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.

公开(公告)号：HU208162B

公开(公告)日：1993-08-30

申请号：HU374090

申请日：1990-05-04

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18 ,  C07K15/04 ,  C07K15/14 ,  A61K37/00 ,  A61K35/12

Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.

公开(公告)号：HUT58352A

公开(公告)日：1992-02-28

申请号：HU374090

申请日：1990-05-04

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18 ,  C07K15/14 ,  A61K37/02

Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.

公开(公告)号：ZA9003475B

公开(公告)日：1992-01-29

申请号：ZA9003475

申请日：1990-05-08

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HANS-GEORG LEMAIRE ,  HILLEN HEINZ ,  HEINZ HILLEN ,  MOELLER ACHIM ,  ACHIM MOELLER ,  DAUM LOTHAR ,  LOTHAR DAUM ,  DOERPER THOMAS ,  THOMAS DOERPER ,  SUBKOWSKI THOMAS ,  THOMAS SUBKOWSKI

IPC: C07K20060101 ,  C07K

公开(公告)号：HU903740D0

公开(公告)日：1992-01-28

申请号：HU374090

申请日：1990-05-04

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.

公开(公告)号：AU3122189A

公开(公告)日：1989-09-14

申请号：AU3122189

申请日：1989-03-10

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  SCHLICK ERICH ,  HERR DIETER ,  GEISS KARL-HEINZ ,  DOERPER THOMAS

IPC: C12N9/99 ,  A61K31/505 ,  A61K31/52 ,  A61K31/715 ,  A61K38/00 ,  A61K38/19 ,  A61K38/21 ,  A61K39/395 ,  A61K45/06 ,  A61P31/12 ,  A61P37/00 ,  A61P43/00 ,  A61K31/725

公开(公告)号：AU2749288A

公开(公告)日：1989-06-29

申请号：AU2749288

申请日：1988-12-23

Applicant: BASF AG

Inventor： HERR DIETER ,  DOERPER THOMAS ,  DAUM LOTHAR ,  GEISS KARL-HEINZ ,  MOELLER ACHIM

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725