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    Mevalonate kinase as a target for fungicides
    31.
    发明专利
    Mevalonate kinase as a target for fungicides 未知

    公开(公告)号：AU2004209042A1

    公开(公告)日：2004-08-19

    申请号：AU2004209042

    申请日：2004-01-28

    Applicant: BASF AG

    Inventor： FREUND ANNETTE ,  LACOUR THIERRY ,  RETHER JAN

    IPC: C12N9/12 ,  C12N15/54 ,  G01N33/50 ,  C12Q1/02

    Abstract: The present invention relates to the provision of mevalonate kinase as target for fungicides, to the provision of novel nucleic acid sequences, of functional equivalents of the abovementioned nucleic acid sequences and to the use of the gene products of the abovementioned nucleic acid sequences as novel targets for fungicides. Moreover, the present invention relates to methods for identifying fungicides which inhibit a polypeptide with the biological activity of a mevalonate kinase and to the use of these compounds identified via the abovementioned method as fungicides.

    Proteins of the ubiquitin proteosome metabolic pathway, useful as targets for identifying fungicides for use in plant protection, also new nucleic acids, proteins and fungicides
    32.
    发明专利
    Proteins of the ubiquitin proteosome metabolic pathway, useful as targets for identifying fungicides for use in plant protection, also new nucleic acids, proteins and fungicides 未知

    公开(公告)号：DE10232773A1

    公开(公告)日：2004-02-05

    申请号：DE10232773

    申请日：2002-07-18

    Applicant: BASF AG

    Inventor： FREUND ANNETTE ,  LACOUR THIERRY ,  RETHER JAN

    IPC: C07K14/37 ,  C07K14/435 ,  A61K38/17 ,  C12N15/11 ,  C12Q1/68

    Abstract: Use of proteins (I) of the ubiquitin proteosome metabolic pathway as targets for fungicides. (I) are encoded by: (a) any of 9 sequences (X; 444-1266 bp), reproduced; (b) sequences (Y) derived by reverse translation, within the degeneracy of the genetic code, from 9 protein sequences (Z), reproduced; or (c) functional equivalents of (a) or (b), having at least 60% identity. Independent claims are also included for the following: (1) new nucleic acid sequences (IIa) that are (X), (Y) and functional equivalents having 65-86% identity with (X) or 71-98% identity with (Y), with the precise minimal degree of identity being specified for each sequence, individually; (2) polypeptides (Ia) encoded by (IIa); (3) method for detecting functional analogs of (X) by preparing a probe and then screening a genomic or cDNA library from the appropriate species, or by computer-based searching for analogs in electronic databases; (4) method for identifying mutations in (I); (5) expression cassette (EC) comprising control sequences linked to (IIa) and/or additional functional elements; (6) vector that contains EC; (7) non-human transgenic organism (bacterium, yeast, fungus or animal or plant cell) that contains (IIa), EC or the vector of (6); (8) method for identifying fungicides; (9) carrier for use in the new methods comprising (IIa), vectors of (6), hosts of (7) and (Ia); and (10) fungicides identified by method (8).

    2-(PIRIDIN-2-IL)-PIRIMIDINAS Y SU USO PARA COMBATIR HONGOS DANINOS.
    35.
    发明专利
    2-(PIRIDIN-2-IL)-PIRIMIDINAS Y SU USO PARA COMBATIR HONGOS DANINOS. 未知

    公开(公告)号：MX2007000620A

    公开(公告)日：2007-03-30

    申请号：MX2007000620

    申请日：2005-07-22

    Applicant: BASF AG

    Inventor： MULLER BERND ,  KOHLE HARALD ,  GRAMMENOS WASSILIOS ,  GROTE THOMAS ,  GEWEHR MARKUS ,  STRATHMANN SIEGFRIED ,  SCHERER MARIA ,  RHEINHEIMER JOACHIM ,  SCHAFER PETER ,  STIERL REINHARD ,  SCHIEWECK FRANK ,  SCHOFL ULRICH ,  BLETTNER CARSTEN ,  SCHWOGLER ANJA ,  RETHER JAN ,  HUNGER UDO

    IPC: A01N43/54 ,  C07D401/04

    Abstract: Compuestos de 2-(piridin--2-il)-pirimidinas de la formula general 1 y su uso para combatir hongos daninos, asi como los agentes fitosanitarios que contienen estos compuestos como componente activo. aqui, k esO, 1,2,63, mes 0, 1,2,3,4 o 5, n es 1,2,3,4,65; R1 es, de modo independiente entre si, halogeno, OH, CN, NO2, alquilo C-C4, halogenalquilo C1-C4, alcoxi C1-C4, halogenalcoxi C1-C4, alquenilo C2-C4, alquinilo C2-C4, cicloalquilo C3-C8, alcoxi C1-C4-alquilo C1-C4, amino, fenoxi, que eventualmente esta sustituido por halogeno o alquilo C1-C4, NHR, NR2, C(Ra)=N_ ORb, S(=O)A1 o C(=O)A2, o dos radicales R1 unidos a atomos de C adyacentes tambien pueden ser juntos un grupo -O-Alk-O-, en donde Alk es alquileno C-C4 lineal o ramificado, en donde 1, 2, 3 6 4 atomos de hidrogeno tambien pueden estar reemplazados por halogeno; R2 es halogenalquilo C1-C4, alcoxi C1-C4, halogenalcoxi C1-C4, hidroxi, halogeno, CN o NO2 en donde R2 tambien puede ser hidrogeno o alquilo C1-C4, cuando se cumple al menos una de las tres condiciones siguientes: - nes3,4o5, - kesl,263, - para m O, al menos uno de los radicales R1 es un radical distinto de halogeno, alquilo C1-C4, alcoxi C1-C4 y halogenalquilo C1-C4 yR3 es alquilo C1-C4.

    TRIFLUOROMETHYL-THIOPHENE CARBOXYLIC ACID ANILIDES AND USE THEREOF AS FUNGICIDES
    39.
    发明专利
    TRIFLUOROMETHYL-THIOPHENE CARBOXYLIC ACID ANILIDES AND USE THEREOF AS FUNGICIDES 未知

    公开(公告)号：CA2519990A1

    公开(公告)日：2004-10-07

    申请号：CA2519990

    申请日：2004-03-20

    Applicant: BASF AG

    Inventor： GROTE THOMAS ,  MUELLER BERND ,  GEWEHR MARKUS ,  SCHIEWECK FRANK ,  RETHER JAN ,  GYPSER ANDREAS ,  GRAMMENOS WASSILIOS ,  TORMO I BLASCO JORDI ,  STIERL REINHARD ,  STRATHMANN SIEGFRIED ,  SCHOEFL ULRICH ,  RACK MICHAEL ,  SCHWOEGLER ANJA ,  BLETTNER CARSTEN ,  RHEINHEIMER JOACHIM

    IPC: C07D333/38 ,  C07D333/12

    Abstract: The invention relates to trifluoromethyl-thiophene carboxylic acid anilides of general formulas I, II, and III, wherein the substituents have the following meaning: R1, R4 independently represent C1-C4alkyl, C3-C6 cycloalkyl, C2-C4 alkenyl, C2-C4 alkinyl, C1-C4 alkoxy, said groups being optionally substitut ed by halogen, H, halogen, nitro, CN; R2 represents H, OH, C1-C4 alkyl, C3-C6 cycloalkyl, C1-C4 alkoxy, said groups being optionally substituted by haloge n; R3 represents C1-C12 alkyl, C3-C12 cycloalkyl, C2-C12 alkenyl, C5-C12 cycloalkenyl, C2-C12 alkinyl, C3-C12 cycloalkyl-C1-C4 alkyl, said groups bei ng optionally substituted by R7; phenyl, phenyl-C1-C6 alkyl, phenyl-C2-C6 alkenyl, phenyl-C2-C6 alkinyl, phenyloxy-C1-C6 alkyl, phenyloxy-C2-C6 alkeny l, phenyloxy-C2-C6 alkinyl, the alkyl portion, alkenyl portion, and alkinyl portion being optionally substituted by R7 and the phenyl ring being optionally substituted by R5; -C(R8)=NOR6; X represents O, S, or a direct bond; R5 represents H, C1-C4alkyl, C3-C6 cycloalkyl, C1-C4 alkoxy, C2-C4 alkenyl, C2-C4 alkinyl, said groups being optionally substituted by halogen, halogen, nitro, CN, phenyl which can be substituted by R1, phenoxy that can be substituted by R1, C1-C6 alkyl-phenyl, the alkyl portion being optionally substituted by halogen andthe phenyl ring being optionally substituted by R1 ; R6 represents C1-C4 alkyl, C3-C6 cycloalkyl, C2-C4 alkenyl, C2-C4 alkinyl, said groups being optionally substituted by halogen, phenyl which can be substituted by R1; R7 represents C1-C4 alkyl, C1-C8 alkoxy, C2-C8 alkenyloxy , C2-C8 alkinyloxy, C1-C4 alkoxy-C1-C8 alkoxy, said groups being optionally substituted by halogen, halogen; R8 represents H, R7, or C1-C12 alkyl, C3-C1 2 cycloalkyl, C2-C12 alkenyl, C5-C12 cycloalkenyl, C3-C12 cycloalkyl-C1-C4 alkyl, said groups being optionally substituted by halogen; phenyl which can be substituted by R5; n represents 0 to 4; and m represents 0, 1. Also disclosed is the use of the inventive trifluoromethyl-thiophene carboxylic acid anilides as fungicides and agents containing said trifluoromethyl- thiophene carboxylic acid anilides.

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