公开(公告)号：AU2007202397A1

公开(公告)日：2007-06-14

申请号：AU2007202397

申请日：2007-05-25

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  LEE HEUNG-SHICK ,  KIM HYUNG-JOON ,  HABERHAUER GREGOR ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  POMPEJUS MARKUS

IPC: C07K14/34 ,  C12N15/31 ,  C12Q1/68

公开(公告)号：AU2007202394A1

公开(公告)日：2007-06-14

申请号：AU2007202394

申请日：2007-05-25

Applicant: BASF AG

Inventor： LEE HEUNG-SHICK ,  HABERHAUER GREGOR ,  KROGER BURKHARD ,  KIM HYUNG-JOON ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  POMPEJUS MARKUS

IPC: C07K14/34 ,  C12N15/31 ,  C12Q1/68

公开(公告)号：CA2615419A1

公开(公告)日：2007-01-25

申请号：CA2615419

申请日：2006-07-18

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  KLOPPROGGE CORINNA ,  HEROLD ANDREA ,  ZELDER OSKAR ,  YOCUM R ROGERS ,  WILLIAMS MARK K

IPC: C12P13/12 ,  C07K14/32 ,  C07K14/34 ,  C12N5/10

Abstract: The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metI gene from Bacillus subtilis or a gene related to metI. In some embodiments of the present invention, the metI gene or another gene is integrated in a fashion that allows for co-production of a water soluble compound such as methionine or other amino acid and a caortenoid compound.

公开(公告)号：CA2615416A1

公开(公告)日：2007-01-25

申请号：CA2615416

申请日：2006-07-18

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  YOCUM ROGERS R ,  HAEFNER STEFAN ,  HERMANN THERON ,  ZELDER OSKAR ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HEROLD ANDREA ,  WILLIAMS MARK K ,  KLOPPROGGE CORINNA

IPC: C12P13/12

Abstract: This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.

公开(公告)号：NO20062695L

公开(公告)日：2006-09-12

申请号：NO20062695

申请日：2006-06-12

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  HAEFNER STEFAN ,  SCHRODER HARTWIG ,  KROGER BURKHARD ,  RUFFER UWE ,  GRAEF CLAUDIA ISABELLA ,  HABERHAUER GREGOR

IPC: C07K14/34

Abstract: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing genetically modified organisms, and to genetically modified organisms themselves.

公开(公告)号：NO20062494L

公开(公告)日：2006-09-06

申请号：NO20062494

申请日：2006-05-31

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KIEFER PATRICK ,  WITTMANN CHRISTOPH ,  KLOPPROGGE CORINNA ,  HEINZLE ELMAR

IPC: C12P13/08 ,  C12N9/16

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：AU2006200795A1

公开(公告)日：2006-03-23

申请号：AU2006200795

申请日：2006-02-24

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  POMPEJUS MARKUS ,  ZELDER OSKAR ,  KROGER BURKHARD ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N15/31

公开(公告)号：AU783697B2

公开(公告)日：2005-11-24

申请号：AU5701400

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569 ,  C12N15/77

Abstract: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which expression vectors have been introduced. The invention still further provides isolated PTS proteins, mutated PTS proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. Glutamicum based on genetic engineering of PTS genes in this organism.

公开(公告)号：AU2003264109A1

公开(公告)日：2004-04-30

申请号：AU2003264109

申请日：2003-08-26

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KROGER BURKHARD

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12 ,  C12R1/15

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with O-acetylhomoserine-sulfhydrolase (metY) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：AU2003264108A1

公开(公告)日：2004-04-30

申请号：AU2003264108

申请日：2003-08-26

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  HAFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with homoserine O-acetyltransferase (metA) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.