公开(公告)号：CA2176507A1

公开(公告)日：1995-05-26

申请号：CA2176507

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROEGER BURKHARD ,  SEULBERGER HARALD ,  MEYER THOMAS ,  SCHMIDT MARTIN ,  JACOB ELARD ,  OTTER RAINER ,  SUBKOWSKI THOMAS ,  HILLEN HEINZ

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91 ,  C12Q1/37

Abstract: The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.

公开(公告)号：DK1040193T3

公开(公告)日：2005-01-03

申请号：DK98966671

申请日：1998-12-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  SEULBERGER HARALD ,  REVUELTA DOVAL JOSE LUIS ,  SANTOS GARCIA MARIA ANGELES

IPC: C12N15/09 ,  C07K14/39 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N15/00 ,  C12N15/52 ,  C12N15/53 ,  C12N15/80 ,  C12P19/28 ,  C12P25/00 ,  C12R1/645

Abstract: Enzymes involved in purine biosynthesis in Ashbya gossypii are new. hosphoribosylpyrophosphate synthetases (KPR1 and 2) comprising 318 or 320 amino acid residues, glutamine-phosphororibosylpyrophosphate amidotransferase (ADE4) comprising 510 amino acid residues, IMP-dehydrogenase (GUA1) comprising 151 or 371 amino acid residues, and a GMP-synthetase (GUA2) comprising 525 amino acid residues or polypeptides with substitution, insertion or deletion of 10-20 % of the amino acid sequence, and the activity of the relative enzyme are new (all sequences fully defined in the specification). Independent claims are also included for: (1) nucleic acid sequences encoding the above enzymes; and (2) the production riboflavin comprising cultivation of a microorganism genetically modified with at least one gene for purine biosynthesis.

公开(公告)号：ES2160829T3

公开(公告)日：2001-11-16

申请号：ES96926334

申请日：1996-07-10

Applicant: BASF AG ,  FORSCHUNGSZENTRUM JUELICH GMBH

Inventor： KASLER BRUNO ,  SAHM HERMANN ,  STAHMANN KLAUS-PETER ,  SCHMIDT GEORG ,  BOEDDECKER THEO ,  SEULBERGER HARALD

IPC: C12N15/00 ,  A23K1/16 ,  C07D475/14 ,  C12N1/15 ,  C12N9/88 ,  C12N15/31 ,  C12N15/60 ,  C12P25/00 ,  C12R1/645

Abstract: PCT No. PCT/EP96/03009 Sec. 371 Date May 1, 1998 Sec. 102(e) Date May 1, 1998 PCT Filed Jul. 10, 1996 PCT Pub. No. WO97/03208 PCT Pub. Date Jan. 30, 1997The disclosure concerns a process for the microbial preparation of riboflavin by culturing riboflavin-producing microorganisms in a nutrient medium and then isolating the riboflavin which has been produced, which comprises using microorganisms in which the endogenous isocitrate lyase (ICL) activity has been altered.

公开(公告)号：DK0839211T3

公开(公告)日：2001-09-03

申请号：DK96926334

申请日：1996-07-10

Applicant: BASF AG ,  FORSCHUNGSZENTRUM JUELICH GMBH

Inventor： SEULBERGER HARALD ,  SAHM HERMANN ,  KAESLER BRUNO ,  STAHMANN KLAUS-PETER ,  SCHMIDT GEORG ,  BOEDDECKER THEO

IPC: C12N15/00 ,  A23K1/16 ,  C07D475/14 ,  C12N1/15 ,  C12N9/88 ,  C12N15/31 ,  C12N15/60 ,  C12P25/00 ,  C12R1/645

Abstract: PCT No. PCT/EP96/03009 Sec. 371 Date May 1, 1998 Sec. 102(e) Date May 1, 1998 PCT Filed Jul. 10, 1996 PCT Pub. No. WO97/03208 PCT Pub. Date Jan. 30, 1997The disclosure concerns a process for the microbial preparation of riboflavin by culturing riboflavin-producing microorganisms in a nutrient medium and then isolating the riboflavin which has been produced, which comprises using microorganisms in which the endogenous isocitrate lyase (ICL) activity has been altered.

公开(公告)号：DE19823834A1

公开(公告)日：1999-12-02

申请号：DE19823834

申请日：1998-05-28

Applicant: BASF AG

Inventor： ALTHOEFER HENNING ,  SEULBERGER HARALD ,  ZELDER OSKAR ,  REVUELTA DOVAL JOSE LUI

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/54 ,  C12N15/80 ,  C12P25/00 ,  C07H21/04 ,  C12N15/63 ,  C12N1/00 ,  C07D475/14

Abstract: The invention relates to a genetic method for producing riboflavin. The production of riboflavin in organisms is increased by specially selecting genes of the riboflavin biosynthesis or of the combination thereof in organisms, especially in bacteria, fungi, yeasts and plants, and of the expression thereof. The invention also relates to a nucleic acid fragment containing genes with the sequences SEQ ID No. 1, SEQ ID No. 3 or SEQ ID No. 5 or the functional equivalents thereof, to expression vectors containing the nucleic acid fragments, and to organisms containing at least one nucleic acid fragment or at least one vector.

公开(公告)号：CA2296840A1

公开(公告)日：1999-01-28

申请号：CA2296840

申请日：1998-06-23

Applicant: BASF AG

Inventor： SCHMIDT RALF-MICHAEL ,  KRUPINSKA KARIN ,  FALK JON ,  SEULBERGER HARALD ,  LERCHL JENS

IPC: C12N9/02 ,  C12N15/53 ,  C12N15/82 ,  A01H5/00 ,  C12N5/10 ,  G01N33/50

Abstract: The invention relates to a method for producing plants with an increased yield of vitamin E from biosynthesis by overexpression of a plant HPPD gene from barley.

公开(公告)号：CA2276110A1

公开(公告)日：1998-07-09

申请号：CA2276110

申请日：1997-12-29

Applicant: BASF AG

Inventor： ALTMANN-JOEHL REGULA ,  SEULBERGER HARALD ,  ALTHOEFER HENNING ,  PHILIPPSEN PETER

IPC: C12N15/09 ,  C07K14/37 ,  C12N1/15 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N15/00 ,  C12N15/31 ,  C12N15/60 ,  C12P25/00 ,  C12Q1/18 ,  C12Q1/68 ,  C12R1/645 ,  C12R1/865 ,  C12N5/10 ,  C12N1/14 ,  C12N1/19 ,  C12N1/20

Abstract: A gene is disclosed which contains the nucleotide sequence represented by SE ID NO:1 and which extends from nucleotide 671 to nucleotide 6295, or a nucleotide sequence derived therefrom by substitution, insertion or deletion of up to 30 %, 20 %, 10 % or 5 % of its nucleotides, the lower percentages being preferable, and whose genetic product exhibits the enzymatic activity of an adenylate cyclase. Also disclosed is its use.

公开(公告)号：SK59896A3

公开(公告)日：1997-07-09

申请号：SK59896

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  SEULBERGER HARALD ,  MEYER THOMAS ,  SCHMIDT MARTIN ,  JACOB ELARD ,  OTTER RAINER ,  SUBKOWSKI THOMAS ,  HILLEN HEINZ

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91 ,  C12N15/11

Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.

公开(公告)号：NO962023L

公开(公告)日：1996-07-16

申请号：NO962023

申请日：1996-05-15

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  SEULBERGER HARALD ,  MEYER THOMAS ,  SCHMIDT MARTIN ,  JACOB ELARD ,  OTTER RAINER ,  SUBKOWSKI THOMAS ,  HILLEN HEINZ

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91

Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.