公开(公告)号：ES2731335T3

公开(公告)日：2019-11-15

申请号：ES15709418

申请日：2015-02-02

Applicant: BASF SE

Inventor： KRAWCZYK JOANNA MARTYNA ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  DANTAS COSTA ESTHER ,  ZELDER OSKAR ,  VON ABENDROTH GREGORY ,  WITTMANN CHRISTOPH ,  STELLMACHER RENÉ ,  BECKER JUDITH ,  LANGE ANNA ,  LYONS BENJAMIN J ,  LYONS THOMAS J ,  DE CRECY EUDES ,  HUGHES EWA

IPC: C12N9/12 ,  C12P7/46

Abstract: Un microorganismo modificado que tiene, en comparación con su tipo silvestre, una actividad reducida de la enzima que está codificada por el gen pykA, en el que la actividad de la enzima codificada por el gen pykA se reduce por modificación genética, en el que la reducción de la actividad la enzima codificada por el gen pykA está en el intervalo de 15 a 99 %, en el que el tipo silvestre del cual se deriva el microorganismo modificado pertenece a la familia de Pasteurellaceae y en el que el tipo silvestre se refiere al microorganismo de origen natural que no ha sido modificado genéticamente.

公开(公告)号：EA032367B1

公开(公告)日：2019-05-31

申请号：EA201590148

申请日：2013-07-03

Applicant: WINTERSHALL HOLDING GMBH ,  BASF SE

Inventor： BROCKMANN BEATA ,  HEROLD ANDREA ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  FLECK CHRISTIAN ,  SCHROEDER HARTWIG ,  GRANSTROEM MARI ,  SCHMIDT JULIA KRISTIANE

IPC: C12N9/10 ,  C12P19/04

Abstract: Изобретениекасаетсягенетическимодифицированныхмикроорганизмов, способныхпродуцироватьβ-глюканы, отличающихсятем, чтоуказанныйгенетическимодифицированныймикроорганизмсверхэкспрессирует: (i) полинуклеотид, кодирующийполипептид, имеющийактивностьсинтазы 1,3-β-D-глюкана, и/или (ii) полипептид, имеющийактивностьсинтазы 1,3-β-D-глюкана, посравнениюс соответствующимнемодифицированныммикроорганизмомтогожештамма. Изобретениетакжекасаетсяпримененияполинуклеотида, кодирующегополипептид, имеющийактивностьсинтазы 1,3-β-D-глюкана, илипримененияуказанногополипептидадляполученияβ-глюканов. Крометого, изобретениекасаетсяспособовполученияβ-глюканов, включающихвведениепромоторапередполинуклеотидом, кодирующимполипептид, имеющийактивностьсинтазы 1,3-β-D-глюкана, темсамымповышаяэкспрессиюуказанногополинуклеотида, илипередполинуклеотидом, кодирующимполипептид, имеющийактивностьсинтазы 1,3-β-D-глюкана, вмикроорганизм, способныйсинтезироватьβ-глюканы.

公开(公告)号：ES2559385T3

公开(公告)日：2016-02-11

申请号：ES09178048

申请日：2009-12-04

Applicant: BASF SE

Inventor： SCHOLTEN EDZARD ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG

IPC: C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/53 ,  C12N15/54 ,  C12N15/60 ,  C12P7/46

Abstract: Una célula bacteriana del género Pasteurella que comprende un polipéptido heterólogo que tiene actividad isocitrato liasa y un polipéptido heterólogo que tiene actividad malato sintasa.

公开(公告)号：CA2942990A1

公开(公告)日：2015-09-24

申请号：CA2942990

申请日：2015-03-18

Applicant: BASF SE

Inventor： DANTAS COSTA ESTHER ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAEFNER STEFAN ,  KRAWCZYK JOANNA MARTYNA ,  VON ABENDROTH GREGORY ,  RIEDELE CHRISTIAN ,  RENZ TORSTEN

IPC: C12P7/46 ,  C07K14/285 ,  C12N9/04 ,  C12N9/10

Abstract: The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I)cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (CRc.c.; in g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRc.c. max; in g per liter per hour).

公开(公告)号：BR112012009483A2

公开(公告)日：2015-09-15

申请号：BR112012009483

申请日：2010-10-18

Applicant: BASF SE

Inventor： SERWE ANNEGRET ,  STOSIK BEATA ,  HAEFNER STEFAN

IPC: C12N1/15 ,  A23K1/165 ,  C12N1/21 ,  C12N9/16 ,  C12N15/55

Abstract: fitase, sequência de ácido nucleico isolada, vetor de expressão recombinante, célula hospedeira recombinante, organismo de produção recombinante, aditivo de ração animal, ração animal, e, uso de uma fitase. a invenção refere-se a uma frase sintética tendo uma estabilidade térmica aumentada e também a uma sequência de ácido nucleico isolada codificadora de uma fitase sintética, e ao uso das fitas em uma ração animal para reduzir o teor de fosfato em esterco, e também aos aditivos de ração animal contendo a fitase sintética.

公开(公告)号：BRPI1006619A2

公开(公告)日：2015-08-25

申请号：BRPI1006619

申请日：2010-03-31

Applicant: BASF SE

Inventor： PIATESI ANDREA ,  SCHWALB CARSTEN ,  KROMM ERICH ,  HÖFFKEN HANS WOLFGANG ,  REICHERT JÜRGEN ,  BALDENIUS KAI-UWE ,  WANG LI-WEN ,  BÜSCHEL MICHAEL ,  PACKE-WIRTH RAINER ,  HAEFNER STEFAN ,  HABICHER TILO

IPC: C12N9/04 ,  D06M16/00

公开(公告)号：CA2938372A1

公开(公告)日：2015-08-13

申请号：CA2938372

申请日：2015-02-05

Applicant: BASF SE

Inventor： KRAWCZYK JOANNA MARTYNA ,  HAEFNER STEFAN ,  SCHRODER HARTWIG ,  DANTAS COSTA ESTHER ,  ZELDER OSKAR ,  VON ABENDROTH GREGORY

IPC: C12N9/10 ,  C12N1/20 ,  C12P7/46

Abstract: The present invention relates to a modified microorganismhaving, compared to its wild-type, a reduced activity of the enzyme that is encoded bythe fruA-gene. The present invention also relates to a method for producing an organic compount and to the use of modified microorganisms.

公开(公告)号：BRPI0911770A2

公开(公告)日：2015-08-04

申请号：BRPI0911770

申请日：2009-04-28

Applicant: BASF SE

Inventor： HEROLD ANDREA ,  SCHRÖDER HARTWIG ,  JEONG WEOL KYU ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  RICHTER ULRIKE ,  BECKER JUDITH ,  WITTMANN CHRISTOPH

IPC: C12P13/00 ,  C12N9/04

公开(公告)号：AU2013285476A1

公开(公告)日：2015-01-22

申请号：AU2013285476

申请日：2013-07-03

Applicant: BASF SE ,  WINTERSHALL HOLDING GMBH

Inventor： BROCKMANN BEATA ,  HEROLD ANDREA ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  FLECK CHRISTIAN ,  SCHRODER HARTWIG ,  GRANSTROM MARI ,  SCHMIDT JULIA KRISTIANE

IPC: C12N9/10 ,  C12P19/04

Abstract: The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that said genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-&bgr;-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity or the use of such a polypeptide for producing &bgr;-glucans. Furthermore, the present invention relates to methods for producing &bgr;-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity thereby increasing the expression of said polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-&bgr;-D-glucan synthase-activity into a microorganism being able to synthesize &bgr;-glucans.

公开(公告)号：CA2880845A1

公开(公告)日：2014-02-27

申请号：CA2880845

申请日：2013-08-13

Applicant: BASF SE

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIME FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRODER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KORBER KARSTEN

IPC: C12N1/21 ,  A61K31/48 ,  C07K14/195 ,  C07K14/37 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N15/31 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12P1/00 ,  C12P17/10

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.