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    MULTI-CHANNEL OPTICAL DETECTION SYSTEM
    35.
    发明专利
    MULTI-CHANNEL OPTICAL DETECTION SYSTEM 未知

    公开(公告)号：CA2331678C

    公开(公告)日：2009-09-15

    申请号：CA2331678

    申请日：1999-05-19

    Applicant: CEPHEID

    Inventor： DORITY DOUGLAS B ,  CHANG RONALD ,  NORTHRUP M ALLEN ,  CHRISTEL LEE A ,  YOUNG STEVEN J ,  PETERSEN KURT E ,  KOVACS GREGORY T A ,  KINTZ GREGORY J ,  HEBERT RAYMOND ,  MCMILLAN WILLIAM A

    IPC: G01N21/63 ,  G01N21/64 ,  G01N21/01 ,  G01N21/03

    Abstract: An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel (2) having a chamber (10) for holding the mixture. The apparatus also includes a heat-exchanging module (37) having a pair of opposing thermal plates (34A, 34B) for receiving the vessel (2) between them and for heating and/or cooling the mixture contained in the vessel. The module (37) also includes optical excitation and detection assemblies (46, 48) positioned to optically interrogate the mixture. The excitation assembly (46) includes multiple light sources (100) and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly (48) includes multiple detectors (102) and a second set of filters for detecting light emitted from the chamber (10) in multiple emission wavelength ranges. The optics assemblies (46, 48) thus provide a multi-channel system for detcting a plurality of different target analytes in the mixture.

    Microstructures for the manipulation of fluid samples
    38.
    发明专利
    Microstructures for the manipulation of fluid samples 未知

    公开(公告)号：AU745989B2

    公开(公告)日：2002-04-11

    申请号：AU8906698

    申请日：1998-08-13

    Applicant: CEPHEID

    Inventor： CHRISTEL LEE ALLAN ,  KOVACS GREGORY T A ,  MCMILLAN WILLIAM A ,  NORTHRUP M ALLEN ,  PETERSEN KURT E ,  POURAHMADI FARZAD

    IPC: G01N31/20 ,  B01D15/08 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C07H1/00 ,  C07H21/00 ,  G01N1/34 ,  G01N27/447 ,  G01N33/53 ,  G01N37/00

    Abstract: The invention presents a microfluidic device and method for separating a desired material, such as nucleic acid, from other materials in a fluid sample. In a preferred embodiment, the device comprises a microfabricated chip (20) having an inlet port (28), an outlet port (30), and an extraction chamber (26) in fluid communication with the ports. The chamber (26) has internal attachment surfaces for capturing the desired material from the fluid sample as the sample flows continuously through the chamber. The captured material may then be eluted by forcing an elution fluid to flow through the chamber (26), thus releasing the material from the internal surfaces into the elution fluid. The flow-through design of the device allows target material from a relatively large volume of fluid sample to be concentrated into a much smaller volume of elution fluid. The internal surfaces are preferably formed by an array of columns (32) integrally formed with a wall of the chamber (26) and extending into the chamber (26). The collumns (32) provide a large surface area for capturing the desired material. The device also preferably includes an integrated heater (34) for increasing elution efficiency.

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