公开(公告)号：ZA8902089B

公开(公告)日：1989-10-25

申请号：ZA8902089

申请日：1989-03-20

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  MENCKE BURGHARD ,  BURGHARD MENCKE ,  KLESEL NORBERT ,  NORBERT KLESEL ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  SELIGER HUBERT ,  HUBERT SELIGER ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  FISCHER GERD ,  GERD FISCHER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34 ,  C07D ,  A61K

CPC classification number: C07D501/34

公开(公告)号：DD272466A5

公开(公告)日：1989-10-11

申请号：DD31865188

申请日：1988-08-03

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  SELIGER HUBERT ,  DOST GUENTER ,  CHATTERJEE SUGATA ,  KALYANAPURAM RAJAGOPALAN DESIK ,  RUPP RICHARD H ,  BIMAL NARESH GANGULI ,  CHRISTOPHER MILTON MATHEW FRAN

IPC: A23K20/195 ,  A61K38/00 ,  A61P3/00 ,  C07K1/02 ,  C07K7/06 ,  C07K7/64 ,  A23K1/17

Abstract: Streptogramin B metal complexes, especially the Cu, Zn and Mn complexes of etamycin, are valuable production promoters in livestock nutrition. They are obtained by reacting neoviridogriseins with metal salts in solution and subsequent neutralisation with bases.

公开(公告)号：AU3153289A

公开(公告)日：1989-09-28

申请号：AU3153289

申请日：1989-03-21

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DURCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURGHARD ,  SELIGER HUBERT ,  ISERT DIETER ,  KLESEL NORBERT ,  SEIBERT GERHARD

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：FI891304A

公开(公告)日：1989-09-23

申请号：FI891304

申请日：1989-03-20

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURGHARD ,  SELIGER HUBERT ,  ISERT DIETER ,  KLESEL NORBERT ,  SEIBERT GERHARD

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34 ,  C07D

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：HUT48643A

公开(公告)日：1989-06-28

申请号：HU408888

申请日：1988-08-04

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  DOST GUENTER ,  DESIKAN KALYANAPURAM R ,  GANGULI BIMAL N ,  SELIGER HUBERT ,  CHATTERJEE SUGATA ,  RUPP RICHARD H

IPC: A23K20/195 ,  A61K38/00 ,  A61P3/00 ,  C07K1/02 ,  C07K7/06 ,  A61K37/02 ,  A23K1/17

Abstract: Streptogramin B metal complexes, especially the Cu, Zn and Mn complexes of etamycin, are valuable production promoters in livestock nutrition. They are obtained by reacting neoviridogriseins with metal salts in solution and subsequent neutralisation with bases.

公开(公告)号：DK138789D0

公开(公告)日：1989-03-21

申请号：DK138789

申请日：1989-03-21

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  DUERCKHEIMER WALTER ,  FISCHER GERD ,  MENCKE BURGHARD ,  SELIGER HUBERT ,  ISERT DIETER ,  KLESEL NORBERT ,  SEIBERT GERHARD

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：CA1161836A

公开(公告)日：1984-02-07

申请号：CA301193

申请日：1978-04-14

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: HOE 77/F 079 CEPHEM DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE of the disclosure: Cephem derivatives of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an aminoprotective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkerlyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of nucleophilic compound, and in which the R2O group is in the syn-position are valuable chemotherapeutic agents which possess a very powerful antimicrobial action against Gram-postive and Gramnegative bacteria, have an unexpectedly god action against penicillinaseforming Staphilococci.

公开(公告)号：DD138423A5

公开(公告)日：1979-10-31

申请号：DD20475278

申请日：1978-04-12

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.

公开(公告)号：FI781131A

公开(公告)日：1978-10-16

申请号：FI781131

申请日：1978-04-13

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  EHLERS EBERHARD ,  SELIGER HUBERT ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61K31/675 ,  A61K31/695 ,  A61P31/04 ,  B23K1/18 ,  B23Q5/033 ,  C07D20060101 ,  C07D277/20 ,  C07D277/40 ,  C07D501/00 ,  C07D501/20 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D501/60 ,  C07D519/06 ,  C07D

Abstract: What are disclosed are cephem compounds of the formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in the syn-position, which compounds are valuable chemotherapeutic agents having a very powerful antimicrobial action against Gram-positive and Gram-negative bacteria and an unexpectedly good action against penicillinase-forming Staphilococci.