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公开(公告)号：CA2213285A1
公开(公告)日：1998-02-19
申请号：CA2213285
申请日：1997-08-18
Applicant: HOECHST AG
Inventor： WINK JOACHIM , MARKUS ASTRID , KURZ MICHAEL , VERTESY LSSSZLO , STAHL WILHELM
IPC: C12P17/18 , A61K31/365 , A61P31/04 , A61P31/10 , A61P33/02 , C07D493/04 , C07H17/08 , C12N1/20 , C12P19/62 , C12R1/465 , C07H19/01 , A61K31/71
Abstract: Novel polyene antibiotics, 3874 H1 to H6, processes for their preparation and use Compounds of the formulae 3874 H1, molecular formula C58H86N2O18, MW 1099.3 (see fig. I) 3874 H2, molecular formula: C59H88N2O18, MW 1113.3 (see fig. II) 3874 H3, molecular formula: C57H87NO18, MW 1074.3 (see fig. III) 3874 H4, molecular formula: C58H84N2O18, MW 1097.3 3874 H5, molecular formula: C59H86N2O18, MW 1111.3 3874 H6, molecular formula: C57H85NO18, MW 1072.3 are suitable for treating fungal diseases and for treating diseases associated with an increased steroid concentration.
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公开(公告)号：NO950971L
公开(公告)日：1995-09-18
申请号：NO950971
申请日：1995-03-14
Applicant: HOECHST AG
Inventor： STAHL WILHELM , WALCH AXEL , DOLL WILFIED , KUHLMANN LUDWIG , PUTTER DIETRICH
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公开(公告)号：HUT67045A
公开(公告)日：1995-01-30
申请号：HU9303538
申请日：1993-12-10
Applicant: HOECHST AG
Inventor： SCHLEYERBACH RUDOLF , GRABLEY SUSANNE , WALCH AXEL , STAHL WILHELM , AHLERS MICHAEL , BARTNIK ECKHART , KRETZSCHMAR GERHARD
IPC: A61K31/715 , A61K31/765 , A61K31/785 , A61K31/80 , A61K47/48 , A61K49/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00 , C07H15/04 , C07H15/203 , C08B37/00 , C08G63/00 , C08G63/06 , C08G64/00 , C08G64/42 , C08G65/16 , C08G67/04 , C08G69/00 , C08G69/10 , C08G73/16 , C07H5/06 , A61K31/70
Abstract: The invention relates to physiologically compatible and physiologically degradable polymer-based carbohydrate receptor blocker with an HLB of 10 to 20, containing: carbohydrate portion - bifunctional spacer - hydrophilic biodegradable polymer - potentiator, where the carbohydrate portion consists of 1 to 20 naturally occurring, identical or different, monosaccharide units and is coupled via one or more bifunctional spacers, which is a natural or synthetic molecule, to a hydrophilic biodegradable polymer, and the polymer in turn is the carrier of one or more spacers and the hydrophilic biodegradable polymer is additionally linked to the potentiator which is a crosslinker, one or more groups with hydrophobic, hydrophilic or ionic properties or a solubility improver, to a method for the preparation and to its use in vivo for blocking carbohydrate-recognising receptors. The carbohydrate receptor blocker induces no incompatibility reaction in vivo either in its totality or in the form of breakdown products.
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公开(公告)号：CA2111129A1
公开(公告)日：1994-06-12
申请号：CA2111129
申请日：1993-12-10
Applicant: HOECHST AG
Inventor： STAHL WILHELM , AHLERS MICHAEL , WALCH AXEL , BARTNIK ECKHART , KRETZSCHMAR GERHARD , GRABLEY SUSANNE , SCHLEYERBACH RUDOLF
IPC: A61K31/715 , A61K31/765 , A61K31/785 , A61K31/80 , A61K47/48 , A61K49/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00 , C07H15/04 , C07H15/203 , C08B37/00 , C08G63/00 , C08G63/06 , C08G64/00 , C08G64/42 , C08G65/16 , C08G67/04 , C08G69/00 , C08G69/10 , C08G73/16 , C08B31/00 , C08G73/10 , A61K39/385 , G01N33/53 , A61K31/70
Abstract: The invention relates to physiologically tolerated and physiologically degradable polymer-based carbohydrate receptor blockers with an HLB* of 10 to 20 containing: carbohydrate portion - bifunctional spacer - hydrophilic, biodegradable polymer - potentiator, where the carbohydrate portion which is composed of 1 to 20 naturally occurring, identical or different, monosaccharide units is coupled via one or more bifunctional spacers, which is a natural or synthetic molecule, to a hydrophilic, biodegradable polymer, where the polymer in turn is the carrier of one or more spacers, and the hydrophilic, biodegradable polymer is additionally linked to the potentiator which is a crosslinker, one or more groups with hydrophobic, hydrophilic or ionic properties or a solubility improver, to a process for the preparation and to their use in vivo for blocking carbohydrate-recognizing receptors. The carbohydrate receptor blocker causes no intolerance reaction in vivo either in its entirety or in the form of degradation products.
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公开(公告)号：CA2143289A1
公开(公告)日：1994-03-31
申请号：CA2143289
申请日：1993-09-13
Applicant: BEIERSDORF AG , HOECHST AG
Inventor： KROEPKE RAINER , PAPE WOLFGANG , SCHNEIDER GUENTHER , STAHL WILHELM , WIESNER MATTHIAS
Abstract: W/O emulsions comprising a water-soluble alkyl glycoside or a mixture of several water-soluble alkyl glycosides.
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Patent Agency Ranking
公开(公告)号：PT848064E
公开(公告)日：2002-05-31
申请号：PT97121438
申请日：1997-12-05
Applicant: HOECHST AG
Inventor： ISERT DIETER , WINK JOACHIM , GUNTHER RIESS DR , STAHL WILHELM , ASZODI JOZSEF , VERTESY LASZLO , KNAUF MARTIN , BELLER DOMINIQUE LE
IPC: C12P1/06 , A61K38/00 , A61K38/10 , A61P31/00 , C07K7/08 , C12N1/20 , C12P21/02 , C12R1/465 , C12R1/645
Abstract: The tridecapeptide of formula (I), designated 'feglymycin', and its salts and chemical equivalents are new. Mpg-Dpg-Val-Dpg-Mpg-Dpg-Mpg-Dpg-Val-Dpg-Mpg-Phe-Asp (I) Mpg = 4-hydroxyphenylglycine residue; Dpg = 3,5-dihydroxyphenylglycine residue. Also new is the microorganism Streptomyces species DSM 11171.
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公开(公告)号：AU708253B2
公开(公告)日：1999-07-29
申请号：AU2332495
申请日：1995-06-28
Applicant: HOECHST AG
Inventor： PEYMANN ANUSCHIRWAN , STAHL WILHELM , BUDT KARL-HEINZ , RUPPERT DIETER , SCHUSSLER HENNING , WAGNER KONRAD
IPC: A61K31/675 , A61P31/12 , C07F9/6584 , A61K31/66
Abstract: Cyclic phosphinic acid derivs. of formula (I) are new: A = gp. of formulae (a) or (b); n = 0 or 1; Y, R = O or S; R = H, alkyl, alkenyl, etc.; R , R * = H, NH2, alkyl, etc.; or R +R * = 3-6 membered ring opt. contg. 1-3 heteroatoms, e.g. O or N; G, F = H, F, Cl, Br, OH or R ; but F = H when G = OH; R = H, 1-20C acyl, or OH pro-drug gp.; B = e.g. -C(L)-; L = e.g. O; D, D* = H, 1-20C Alk , R or R -(1-6C Alk ); Alk = satd., mono- or multiply-unsatd. or cyclic alkyl, etc.; R = satd., unsatd. or partly unsatd. 3-35C isocyclic or heterocyclic ring system contg. 3-9 membered rings, etc.; E, E* = H, satd. or unsatd. 1-7C alkyl opt. mono-, di- or tri-substd. by F, Cl, Br or 1-3C alkoxy, etc..
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公开(公告)号：CA2224025A1
公开(公告)日：1998-06-13
申请号：CA2224025
申请日：1997-12-08
Applicant: HOECHST AG
Inventor： LE BELLER DOMINIQUE , STAHL WILHELM , KNAUF MARTIN , ASZODI JOZSEF , WINK JOACHIM , ISERT DIETER , VERTESY LASZLO , RIESS GUENTHER
IPC: C12P1/06 , A61K38/00 , A61K38/10 , A61P31/00 , C07K7/08 , C12N1/20 , C12P21/02 , C12R1/465 , C12R1/645
Abstract: Novel antibiotic feglymycin, process for its preparation and its use. Compound of the formula (see fig. I)
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39.发明专利
公开(公告)号：MX9706283A
公开(公告)日：1998-02-28
申请号：MX9706283
申请日：1997-08-18
Applicant: HOECHST AG
Inventor： VERTESY LSSSZLO , KURZ MICHAEL , WINK JOACHIM , MARKUS ASTRID , STAHL WILHELM
IPC: C12P17/18 , A61K31/365 , A61P31/04 , A61P31/10 , A61P33/02 , C07D493/04 , C07H17/08 , C12N1/20 , C12P19/62 , C12R1/465 , C12P17/08
Abstract: Compuestos de las formulas, 3874 H1, formula empírica: C58H86N2O18, PM 1099,3 3874 H2, formula empírica; C59H88N2O18, PM 1113,3 3874 H3, formula empírica: C57H87NO18, PM 1074, 3 3874 H4, formula empírica: C58H84N2O18, PM 1097, 3 3874 H5, formula empírica: C59H86N2O18, PM 1111, 3 3874 H6, formula empírica: C57H85NO18, PM 1072, 3, son adecuados para el tratamiento de enfermedades por hongos y para el tratamiento de enfermedades que van acompañadas de una concentracion incrementada de esteroides.
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公开(公告)号：AT160936T
公开(公告)日：1997-12-15
申请号：AT93920705
申请日：1993-09-13
Applicant: BEIERSDORF AG , HOECHST AG
Inventor： KROEPKE RAINER , PAPE WOLFGANG , SCHNEIDER GUENTHER , STAHL WILHELM , WIESNER MATTHIAS
Abstract: PCT No. PCT/EP93/02465 Sec. 371 Date Feb. 22, 1995 Sec. 102(e) Date Feb. 22, 1995 PCT Filed Sep. 13, 1993 PCT Pub. No. WO94/06408 PCT Pub. Date Mar. 31, 1994A W/O emulsion comprising water, oil and at least one water-soluble alkyl glycoside. Cosmetic and dermatological skincare composition, based thereon are easier to prepare, of lower viscosity and improved stability.
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