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    BLOOD FLOW MEASURING METHOD AND BLOOD FLOW MEASURING DEVICE
    33.
    发明专利
    BLOOD FLOW MEASURING METHOD AND BLOOD FLOW MEASURING DEVICE 失效

    公开(公告)号：JPH08182658A

    公开(公告)日：1996-07-16

    申请号：JP33959494

    申请日：1994-12-28

    Applicant: KAO CORP

    Inventor： NAGASHIMA YOSHINAO ,  KAWAI MICHIO ,  AKASAKI SHUICHI ,  KAMIYA TETSURO ,  SAITO TAKEO

    IPC: A61B5/026

    Abstract: PURPOSE: To record a broad range of blood flow amount of respective deepness from a superficial site to a deep site of a skin tissue simultaneously, so as to analyze change of the blood flow in the skin tissue precisely. CONSTITUTION: Plural positions of different distances from a light transmitting part 16 are made light receiving parts 15a-15e against at least one light transmitting part 16 for making a laser beam incident into a testee and scattered light from the testee is received at each light receiving part 15a-15e and blood flow amount in each light receiving part is measured, thereby, blood flow amounts of different measuring deepnesses are recorded simultaneously, in a blood flow measuring method of laser-Doppler type by which the laser beam is made incident into the testee and scattered light in the testee is received to measure the blood flow of the testee. On this occasion, preferablly, plural light receiving parts 15a-15e are formed respectively according to the distances from the light transmitting part, and preferablly the power of laser beam made incident to the testee is varied.

    DETECTION METHOD FOR PORPHYRIN ON SKIN
    34.
    发明专利
    DETECTION METHOD FOR PORPHYRIN ON SKIN 失效

    公开(公告)号：JPH05103771A

    公开(公告)日：1993-04-27

    申请号：JP26961891

    申请日：1991-10-17

    Applicant: KAO CORP

    Inventor： NAGASHIMA YOSHINAO ,  OSANAI TSUKASA ,  NEGISHI KEIKO ,  KITAHARA TAKASHI ,  IKEDA NORIKO ,  KAWAI MICHIO

    IPC: A61B5/00 ,  A61B5/107 ,  A61B10/00 ,  G01N21/64 ,  G01N33/50

    Abstract: PURPOSE:To detect easily and accurately skin surface porphyrin inclusive of a measurement place as a color image and conduct observation by preventing the temperature ascent of a CCD by cooling the CCD by means of a cooling mechanism, using feeble ultraviolet rays that contain visible light and do not have a bad effect on a skin. CONSTITUTION:In the case of a Peltier cooling type CCD color camera 4, cooling is carried out by means of a Peltier element to prevent the temperature ascent of a CCD module. Also, the temperature ascent of the Peltier element is cooled by means of a circulation liquid from a cooling drive unit 5. Thus, when spectrum is received, a color image signal that is normal at all times can be outputted. As a result, skin surface porphyrin can be detected and observed quickly with ease and accuracy as a color stationary image through a TV monitor 7 even at a feeble ultraviolet ray quantity without causing a bad effect on a skin. Also, visible light is contained in irradiation light from a light source 1, too, so the contour of the place of a human body also can be indicated as an image, and a porphyrin measurement place can come to be grasped clearly.

    ABSORBEFACIENT IN ARIMENTARY CANAL
    35.
    发明专利
    ABSORBEFACIENT IN ARIMENTARY CANAL 失效

    公开(公告)号：JPH02249468A

    公开(公告)日：1990-10-05

    申请号：JP7080089

    申请日：1989-03-23

    Applicant: KAO CORP

    Inventor： NAGASHIMA YOSHINAO ,  MURATA SHOICHI ,  HARA KENJI

    IPC: A23L1/30 ,  A23L1/304 ,  C07H11/04

    Abstract: PURPOSE:To obtain the subject absorbefacient effectively absorbing inorganic substance contained in foods, etc., to interior of the body in excellent balance with mixing in foods or peroral drug composition by containing saccharide phosphate. CONSTITUTION:Saccharide phosphate (e.g. glucose-1-phosphoric acid, glucose-6- phosphoric acid, glucose-1,6-diphosphoric acid, fructose-1-phosphoric acid, fructose-6-phosphoric acid, fructose-1,6-diphosphoric acid or fructose-2,6- diphosphoric acid) is contained in the aimed absorbefacient.

    PREVENTIVE AND REMEDY FOR HYPERTENSION
    36.
    发明专利
    PREVENTIVE AND REMEDY FOR HYPERTENSION 失效

    公开(公告)号：JPS63198629A

    公开(公告)日：1988-08-17

    申请号：JP3123387

    申请日：1987-02-13

    Applicant: KAO CORP

    Inventor： MURATA SHOICHI ,  NAGASHIMA YOSHINAO ,  HARA KENJI ,  KAYANE SHIGETO ,  IMAMURA TAKASHI

    IPC: C07H11/04 ,  A61K31/70 ,  A61P9/10 ,  A61P9/12

    Abstract: PURPOSE:To obtain a preventive and remedy for hypertension having immediate effects free from side effects, containing a calcium hexose phosphate as an active ingredient. CONSTITUTION:A calcium hexose phosphate (e.g. calcium glucose-1-phosphate) and, if necessary, a given carrier for preparation, excipient, etc., are pharmaceutically manufactured by a conventional procedure to give the aimed substance. The substance can be made into tablets, granules, capsule agents, oral administration agent, etc. A dose is 0.1-20g, preferably 1-15g calculated as calcium hexose per person daily. Acute toxicity of mouse of calcium glucose-1-phosphate is >=15,000mg/kg and the substance is extremely safe. The substance can suppress rise in blood pressure and prevent and treat diseases such as myocardial infarction, cerebral apoplexy, liver cirrhosis, cholestasia, etc., wherein hypertension is considered one cause of crisis.

    Brain fatigue relieving agent
    37.
    发明专利
    Brain fatigue relieving agent 审中-公开
    大脑疲劳消除剂

    公开(公告)号：JP2007297296A

    公开(公告)日：2007-11-15

    申请号：JP2006124758

    申请日：2006-04-28

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SADATE HIDETOSHI ,  NAGASHIMA YOSHINAO ,  WATANABE TAKUYA

    IPC: A61K31/216 ,  A23L1/30 ,  A61K31/122 ,  A61K31/192 ,  A61P3/02 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To provide an agent for relieving brain fatigue such as the lowering of numeric ability caused by brain fatigue. SOLUTION: The agent for relieving the fatigue of human brain comprises (a) one or more compounds selected from chlorogenic acids, caffeic acid, ferulic acid and their pharmacologically allowable salts and (b) coenzyme Q 10 . COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：提供减轻脑疲劳的药剂，例如降低由脑疲劳引起的数字能力。 解决方案：用于缓解人脑疲劳的药剂包括（a）一种或多种选自绿原酸，咖啡酸，阿魏酸及其药理学允许盐的化合物和（b）辅酶Q SB <10 >。 版权所有（C）2008，JPO＆INPIT

    Cosmetic method
    38.
    发明专利
    Cosmetic method 审中-公开

    公开(公告)号：JP2004195255A

    公开(公告)日：2004-07-15

    申请号：JP2004092508

    申请日：2004-03-26

    Applicant: Kao Corp ,  花王株式会社

    Inventor： NAGASHIMA YOSHINAO ,  YADA YUKIHIRO ,  KATO YURI

    IPC: A61H23/06 ,  A61H7/00 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61Q90/00 ,  A61K7/00

    Abstract: PROBLEM TO BE SOLVED: To provide a cosmetic method composed of a massage for easily executable even by an general person, and attaining the large cosmetic effect. SOLUTION: This cosmetic method gives the massage in the dermis fiber direction for improving a skin color, improving dullness of the skin, preventing comes-off of makeup or improving the spread of the makeup, and gives a massage in the bloodstream direction of the artery, and next, gives a massage in the bloodstream direction of a vein together with a massage in the dermis fiber direction. COPYRIGHT: (C)2004,JPO&NCIPI

    Hair cosmetic
    39.
    发明专利
    Hair cosmetic 审中-公开
    头发化妆品

    公开(公告)号：JP2003055161A

    公开(公告)日：2003-02-26

    申请号：JP2001244909

    申请日：2001-08-10

    Applicant: Kao Corp ,  花王株式会社

    Inventor： NAGASHIMA YOSHINAO ,  YADA YUKIHIRO

    IPC: A61K8/00 ,  A61K8/34 ,  A61K8/89 ,  A61K8/891 ,  A61Q5/00 ,  A61Q5/06 ,  C08L83/04 ,  A61K7/06

    Abstract: PROBLEM TO BE SOLVED: To prepare a hair cosmetic capable of imparting a sufficient smoothness and wet feeling to the hair, not only realizing an easy styling but also stabilizing the spirit of a user for relaxing the mental stress without being dominated by the taste of the user and individual difference of sensitivity, and further capable of giving a comfortable sleep to the user.
    SOLUTION: This hair-dressing material contains the following (A), (B) and (C): (A) A sesquiterpen alcohol having ≥250°C boiling point; (B) A surfactant; (C) A silicone oil; Especially as the component (A), cedrol is used.
    COPYRIGHT: (C)2003,JPO

    Abstract translation: 要解决的问题：为了制备能够赋予头发足够的平滑度和湿润感的头发美容品，不仅实现了容易的造型，而且稳定了使用者的精神以放松精神压力，而不被主体的味道所控制 用户和个人的灵敏度差异，并且还能够给用户舒适的睡眠。 解决方案：该发型材料含有以下（A），（B）和（C）：（A）> = 250℃沸点的倍半萜醇; （B）表面活性剂; （C）硅油; 特别是作为组分（A），使用雪松灵。

    METHOD AND APPARATUS FOR EVALUATING SKIN CONDITION
    40.
    发明专利
    METHOD AND APPARATUS FOR EVALUATING SKIN CONDITION 失效

    公开(公告)号：JP2001112742A

    公开(公告)日：2001-04-24

    申请号：JP30026499

    申请日：1999-10-21

    Applicant: KAO CORP

    Inventor： NAGASHIMA YOSHINAO ,  SUGATA KEIICHI ,  YADA YUKIHIRO

    IPC: A61B5/00 ,  A61B5/107

    Abstract: PROBLEM TO BE SOLVED: To allow even an ordinary person to noninvasively and easily evaluate the condition of her skin, such as the degree of fatigue, etc. SOLUTION: Laser beams are made to simultaneously impinge on a plurality of measuring points on the skin, and the laser beams reflected from the skin are received and converted into blood flow signals. Signals corresponding to two or more specific frequency bandwidths are extracted from the blood flow signals, and the signal strengths which correspond to the different frequency bandwidths are compared with each other to evaluate the condition of the skin.

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