公开(公告)号：FR2842407A1

公开(公告)日：2004-01-23

申请号：FR0209099

申请日：2002-07-18

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: A61B1/00 ,  G01N21/64 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：CA2491751C

公开(公告)日：2015-10-13

申请号：CA2491751

申请日：2003-07-11

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  BERIER FREDERIC

IPC: A61B1/04 ,  G06T5/00

Abstract: L'invention concerne un procede de traitement d'image acquise au moyen d'un guide constitué par une pluralité de fibres optiques. Selon l'invention, pour chaque fibre optique, on isole sur l'image acquise une zone correspondante à cette fibre optique, on traite localement chaque zone de façon individuelle pour corriger le flux de photon détecté dans chaque fibre optique, puis on reconstruit l'image acquise en éliminant le motif dû aux fibres optiques. Le procédé comprend également un processus d'étalonnage permettant d'obtenir, pour chaque fibre optique et à partir d'une image d'étalonnage, un taux d'injection étalon qui va servir à la reconstruction des images acquises. Le procédé comprend également en premier lieu une étape de détection des fibres à partir d'une image témoin.

公开(公告)号：CA2550305C

公开(公告)日：2014-07-08

申请号：CA2550305

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  PERCHANT AYMERIC

IPC: G06T5/50

Abstract: L~invention concerne un procédé pour augmenter la résolution d~images confocales acquises à travers un guide d~image dont l~extrémité distale est associée à une tête optique pour focaliser le faisceau laser émis par le guide d~image dans un objet d~observation. Selon l~invention, pour une position donnée de la tête optique, ce procédé comprend les étapes de : réalisation d~une pluralité d~acquisitions à travers le guide d~image, chaque acquisition étant réalisée pour un décalage spatial donné de ladite extrémité distale du guide d~image par rapport à la tête optique qui reste fixe ; transformation des données de chaque acquisition en un nuage de points ; recalage de chaque nuage de points par rapport à un nuage de points pris comme référence ; superposition des nuages de points ainsi recalés ; et reconstruction d~une image finale à partir de cette superposition. Avantageusement, on utilise un tube piézoélectrique commandé disposé autour de l~extrémité distale du guide d~image pour déplacer ce dernier.

公开(公告)号：ES2383526T3

公开(公告)日：2012-06-21

申请号：ES04817612

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  PERCHANT AYMERIC

IPC: G06T3/40 ,  G06T5/50

Abstract: Procedimiento para aumentar la resolución de imágenes confocales adquiridas a través de una guía de imagenconstituido por varias fibras ópticas, el extremo próximo de esta guía de imagen está conectada a un dispositivo debarrido láser previsto para emitir un haz láser en cada fibra óptica de la guía de imagen y recoger cada haz deretorno en el momento de una adquisición, el extremo distal está asociado a una cabeza óptica para enfocar el hazláser emitido por la guía de imagen en un objeto de observación, caracterizado porque, para una posicióndeterminada de la cabeza óptica, este procedimiento consta de las etapas de:- Realización de varias adquisiciones a través de la guía de imagen, cada adquisición se realiza para una desviaciónespacial determinada de dicho extremo distal de la guía de imagen con respecto a la cabeza óptica,- Transformación de los datos de cada adquisición en una nube de puntos ponderada por la potencia óptica medidasobre el objeto a través de cada fibra óptica de la guía de imagen,- Registro de cada nube de puntos con respecto a una nube de puntos tomados como referencia,- Superposición de las nubes de puntos así registrados, y- Reconstrucción de una imagen final a partir de esta superposición

公开(公告)号：AT547772T

公开(公告)日：2012-03-15

申请号：AT04817612

申请日：2004-12-29

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： BERIER FREDERIC ,  PERCHANT AYMERIC

IPC: G06T3/40 ,  G06T5/50

Abstract: The method involves performing a set of acquisitions across an image guide (1). Each acquisition is performed for a given spatial offset at a distal end of the guide with respect to an optical head. Each acquired data is transformed in a scatter diagram and each diagram is readjusted with respect to a reference scatter diagram. A final image is reconstructed by superimposing readjusted diagram. Independent claims are also included for the following: (A) a device for enhancing resolution of confocal image acquired across an image guide (B) a system implementing confocal image resolution enhancing method.

公开(公告)号：FR2864438B1

公开(公告)日：2006-11-17

申请号：FR0315627

申请日：2003-12-31

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： MATHIEU GILLES ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC

IPC: A61B1/07 ,  A61B1/00 ,  A61B1/005 ,  A61B1/04 ,  A61B1/05 ,  A61B5/00 ,  G02B6/06 ,  G02B6/26 ,  G02B6/35 ,  G02B7/02 ,  G02B21/00 ,  G02B26/08 ,  G02B26/10 ,  H01J3/14

Abstract: The head has a laser source to produce a light beam (13), and a ball lens (12), with a large numerical aperture, disposed at the end of the head to converge the beam at an excitation point (19). The point is located in an observed sub-surface field (14) of a sample (15). A scanning unit (10) displaces the source in rotation such that the point scans the field. An independent claim is also included for a confocal imaging system.

公开(公告)号：DE60205408D1

公开(公告)日：2005-09-08

申请号：DE60205408

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES PARIS

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.

公开(公告)号：FR2842407B1

公开(公告)日：2005-05-06

申请号：FR0209099

申请日：2002-07-18

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： GENET MAGALIE ,  VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  CLADE SOPHIE

IPC: G01N21/64 ,  A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/10 ,  H04N1/028

Abstract: The method consists in deflecting the excitation signal at a speed corresponding to acquisition of a number of images per second sufficient for real time use and in detecting the fluorescence signal at a detecting frequency corresponding to a minimum frequency for sampling the fibers one by one. The method uses an image guide consisting of several thousands of optical fibers, an excitation signal being emitted by a source, deflected and injected by turns into the optical fibers of the guide, each excitation point of the tissue in the fiber output emitting in return a fluorescence signal collected by the fiber, then detected and digitized to form an image element. The method also provides for the focussing of the beam in the fiber output to excite a subsurface plane to produce a confocal image. The method also provides for the production of a divergent beam in the fiber output capable of exciting a micro-volume of the tissue from the surface.

公开(公告)号：FR2849215B1

公开(公告)日：2005-03-11

申请号：FR0216276

申请日：2002-12-20

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  BERIER FREDERIC ,  BONIFACE JEAN MICHEL

IPC: G02B21/00 ,  G02B23/24

Abstract: Light from a matrix of lasers (23) is focussed by an optical unit (24) on to an object (25). The lasers are vertical cavity surface emitting lasers (VCSEL) and each laser has a photo-detector (22) mounted at the rear and able to receive reflected light from the object. The photo-detector signals are amplified and digitized by a processing unit (21) and sent to a control unit (26) which controls the matrix and optical unit Independent claims are also included for the following: (1) An application of the system in which the miniature head is deployed at the head of an endoscope; (2) A method for realizing confocal parallel laser microscopy in which a photo-detector is attached to the rear of each laser to receive light returning from the object and the laser cavities are used as filters.

公开(公告)号：FR2834349B1

公开(公告)日：2004-04-09

申请号：FR0116980

申请日：2001-12-28

Applicant: MAUNA KEA TECHNOLOGIES

Inventor： VIELLEROBE BERTRAND ,  GENET MAGALIE ,  BERIER FREDERIC ,  LACOMBE FRANCOIS ,  PERCHANT AYMERIC ,  LE GOUALHER GEORGES ,  MARTI SANDRA ,  BOURRIAUX STEPHANE

IPC: G02B23/26 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07 ,  G02B21/00 ,  G02B23/24 ,  G02B26/10 ,  G06F19/00

Abstract: Equipment includes an image guide ( 1 ) consisting of flexible optical fibers with: on the proximal end side: a source ( 2 ), angular scanning elements ( 3 ), injection elements ( 4 ) in one of the fibers, elements for splitting ( 5 ) the illuminating beam and the backscattered signal, elements for spatial filtering ( 6 ), elements for detecting ( 7 ) the signal, electronic elements ( 8 ) for controlling, analyzing and digital processing of the detected signal and display; and on the distal end side: an optical head ( 9 ) for focusing the illuminating beam exiting from the illuminated fiber. The scanning elements include a resonant line mirror (M 1 ) and a galvanometric field mirror (M 2 ) with a variable frequency and two afocal optical systems adapted to conjugate the two mirrors (M 1 , M 2 ) firstly in the field mirror (M 2 ) and the injection elements ( 4 ) in the image guide in a second step.