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    32.
    发明专利
    未知

    公开(公告)号：AT344800T

    公开(公告)日：2006-11-15

    申请号：AT03809363

    申请日：2003-10-17

    Applicant: SERVIER LAB

    Inventor： COUDERT GERARD ,  AYERBE NATHALIE ,  LEPIFRE FRANCK ,  ROUTIER SYLVAIN ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE ,  HICKMAN JOHN ,  PIERRE ALAIN ,  LEONCE STEPHANE

    IPC: A61P35/00 ,  C07D471/14 ,  C07D487/04 ,  C07D491/14 ,  C07D491/147 ,  C07D491/22 ,  C07D498/14 ,  C07D498/22 ,  A61K31/5365

    Abstract: 1,4-benzodioxino(2,3-e)isoindole derivatives (I) are new. 1,4-benzodioxino(2,3-e)isoindole derivatives of formula (I) and their enantiomers, diastereoisomers, N-oxides and addition salts with acids and bases are new. A = atoms that complete groups of formula (a) or (b); W1 = atoms that complete a phenyl or pyridyl ring; Z' = H, halogen, 1-6C alkyl or alkoxy (both optionally substituted by aryl), nitro, cyano, hydroxy, aryl, or NR5R6; R5, R6 = H or 1-6C alkyl; R4 = H, 1-6C alkyl, aryl, aryl(1-6C)alkyl or COOR'5; R'5 = 1-6C alkyl, aryl or aryl(1-6C)alkyl; Y' = oxygen or methylene; R2 = H; and R3 = H, 1-6C alkyl, aryl, aryl(1-6C)alkyl or trifluoromethylsulfonyl; or R2+R3 = bond; R1 = H, 1-6C alkyl, aryl, aryl(1-6C)alkyl, or 1-6C alkylene, substituted by one or more of OR5 or NR5R6; Z1, Z2 = H or; Z1+Z2 = fused phenyl; and aryl = phenyl, naphthyl, di- or tetra-hydronaphthyl, indenyl or indanyl (all optionally substituted by one or more of halo, 1-6C (trihalo)alkyl or alkoxy, hydroxy, amino or mono- or di-1-6C alkylamino. Provided that if Z' is H, then R1 is not H. Independent claims are included for preparing (I).

    АКУТУМИН И СОЕДИНЕНИЯ АКУТУМИНА, СИНТЕЗ И ПРИМЕНЕНИЕ
    33.
    发明专利
    АКУТУМИН И СОЕДИНЕНИЯ АКУТУМИНА, СИНТЕЗ И ПРИМЕНЕНИЕ 未知

    公开(公告)号：EA007229B1

    公开(公告)日：2006-08-25

    申请号：EA200500081

    申请日：2003-06-16

    Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB

    Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

    IPC: C07D217/20 ,  A61K31/47 ,  A61P25/28 ,  C07D209/96

    Abstract: Изобретениеотноситсяк акутуминуи егосоединениям, атакжек соединениямформулы (I)вкоторых Rи R, каждыйпредставляетсобойатомводородаиливместеобразуютдополнительнуюсвязь, Rпредставляетсобойатомводородаилиалкоксигруппу, Rпредставляетсобойатомводородаилихлора, Rпредставляетсобойатомводородаилиалкильную, алкилкарбонильнуюилиароильнуюгруппу, Rи R, каждыйпредставляетсобойалкоксигруппу, Rпредставляетсобойалкоксигруппу, R, R, R, R, R, Rи Rимеютзначения, указанныев описании. Лекарственныесредства.

    Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same
    37.
    发明专利
    Imidazopyridine derivatives, preparation method and pharmaceutical compositions containing same 未知

    公开(公告)号：HK1081964A1

    公开(公告)日：2006-05-26

    申请号：HK06102330

    申请日：2006-02-22

    Applicant: SERVIER LAB

    Inventor： RAULT SYLVAIN ,  LANCELOT JEAN-CHARLES ,  KOPP MARINA ,  CAIGNARD DANIEL-HENRI ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  BIZOT-ESPIARD JEAN-GUY

    IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  C07D471/04

    Abstract: Imidazopyridine derivatives (I) are new. Imidazopyridine derivatives of formula (I), their enantiomers, diastereoisomers, and their salts with acids and bases are new. R1 = H, halogen, alkyl, polyhaloalkyl, CN, NO2, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, or dialkylaminocarbonyl; R2 = H, alkyl, aryl (optionally substituted), heteroaryl (optionally substituted) or a group of formula R20-C(X)-; R20 = alkyl, alkoxy, amino, alkylamino, dialkylamino, aryl (optionally substituted), or heteroaryl (optionally substituted); X = O, S, or NR21; R21, R3 = H or alkyl; n = 1-6; and N = pyrido ring with the N atom in the 1, 2, 3, or 4 positions. Alkyl and alkoxy groups have 1-6 C atoms, aryl is phenyl or naphthyl, polyhaloalkyl groups having 1-3 C atoms and 1-7 halogen atoms, heteroaryl groups may be mono or bicyclic of 5 - 11 ring atoms, at least one ring being aromatic, and having 2 or 3 heteroatoms (O, N, S) and may be substituted by 1-3 alkyl groups. Optional substituents on aryl groups may be 1 or 2 substituents selected from halogens, alkyl, alkoxy, polyhaloalkyl, hydroxy, CN, NO2, amino, alkylamino, dialkylamino, carboxyl, amido, and -COO-alkyl groups, and heteroaryl groups having a non-aromatic ring may be further substituted on this non-aromatic ring by oxo.

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