公开(公告)号：AT279255T

公开(公告)日：2004-10-15

申请号：AT01116443

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  G05D16/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：DE69917946D1

公开(公告)日：2004-07-15

申请号：DE69917946

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：CA2538983A1

公开(公告)日：2002-07-26

申请号：CA2538983

申请日：2002-01-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HIGASHIHARA KENNETH S ,  TROTH JONAH R ,  FREITAG J CHRISTOPHER ,  FRANK TREVOR G ,  DIAMOND GARY M ,  CHANDLER WILLIAM H JR ,  MURPHY VINCE ,  DALES G CAMERON ,  HUFFMAN DAVE

IPC: B01J8/20 ,  B25J11/00

Abstract: A method of preparing and delivering a slurry into a series of vessels in a reactor. The method comprises (1) mixing a particulate solid material and a liquid dispersing medium and agitating the mixture to form a substantially homogeneous first slurry in which the particulate solid material is suspended in the liquid; (2) aspirating the first slurry into a cannula carried by a robot system while the slurry is substantially homogeneous; (3) operating the robot system to insert the cannula into the reactor; (4) delivering the slurry from the cannula into the vessel while the cannula is in the reactor; and, (5) repeating (2)-(4) for a second vessel with the first slurr y or repeating (2)-(4) for a second vessel with a second slurry.

公开(公告)号：CA2369222A1

公开(公告)日：2002-07-26

申请号：CA2369222

申请日：2002-01-23

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HIGASHIHARA KENNETH S ,  MURPHY VINCE ,  DALES G CAMERON ,  FRANK TREVOR G ,  DIAMOND GARY M ,  FREITAG J CHRISTOPHER ,  TROTH JONAH R ,  CHANDLER WILLIAM H JR ,  HUFFMAN DAVE

IPC: B01J19/26 ,  B01F7/00 ,  B01F7/16 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B25J9/02 ,  C40B40/14 ,  C40B40/18 ,  C40B60/00 ,  C40B60/14 ,  F28F27/00 ,  G01K13/00 ,  G01N1/22 ,  G01N21/25 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  B08B3/00 ,  B25J11/00 ,  B01J8/14

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including slurries, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods and cannula designs are also disclosed.

公开(公告)号：CA2306807A1

公开(公告)日：2000-02-24

申请号：CA2306807

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MCFARLAND ERIC ,  VAN BEEK JOHANNES A M ,  VAN ERDEN LYNN ,  HAJDUK DAMIAN A ,  DALES G CAMERON ,  MATSIEV LEONID ,  NIELSEN RALPH B ,  MANSKY PAUL ,  TURNER HOWARD ,  WANG PEI

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：WO9951980A3

公开(公告)日：2001-03-22

申请号：PCT/US9907304

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CARLSON ERIC ,  SAFIR ADAM ,  PETRO MIROSLAV ,  NIELSEN RALPH B ,  LEE THOMAS S ,  FRECHET JEAN M J ,  DALES G CAMERON ,  KUEBLER SIGRID C ,  BENNETT JAMES

IPC: G01N37/00 ,  B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  C40B40/18 ,  G01N1/00 ,  G01N15/02 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/08

CPC classification number: G01N35/1097 ,  B01D15/08 ,  B01D15/12 ,  B01D15/14 ,  B01D15/1871 ,  B01D15/26 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00344 ,  B01J2219/00351 ,  B01J2219/00452 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  C40B40/14 ,  C40B40/18 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/461 ,  G01N30/466 ,  G01N30/54 ,  G01N30/60 ,  G01N30/6052 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/085 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/885 ,  G01N2030/8886 ,  G01N2035/1058 ,  Y10T436/11 ,  Y10T436/25

Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

Abstract translation: 公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。 优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。 还公开了高通量，自动采样系统和方法，高温表征系统和方法，以及快速，间接校准组合物和方法。 所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

公开(公告)号：WO02066151A3

公开(公告)日：2003-02-27

申请号：PCT/US0202617

申请日：2002-01-28

Applicant: SYMYX TECHNOLOGIES INC ,  SMITH MATTHEW F ,  VARNI JOHN F ,  DALES G CAMERON ,  FRANK TREVOR G ,  JAIN RAKESH ,  VAN ERDEN LYNN

Inventor： SMITH MATTHEW F ,  VARNI JOHN F ,  DALES G CAMERON ,  FRANK TREVOR G ,  JAIN RAKESH ,  VAN ERDEN LYNN

IPC: B01J19/00 ,  C40B40/14 ,  C40B60/14

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00313 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00373 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  Y10T436/2575 ,  Y10T436/25875

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures (9M), and a cannula (21) for introducing fluid reaction material into the vessels. A robot system (23) is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases (507), to respective vessels (9M), and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.

Abstract translation: 一种并联反应器系统，包括用于保持反应混合物（9M）的反应器中的反应器和容器，以及用于将流体反应材料引入容器中的插管（21）。 机器人系统（23）可操作以将插管插入反应器中的插管通道中，用于将包括冷凝气体（507）的反应材料输送到相应的容器（9M），并在输送后从套管通道中抽出套管。 还公开了相关方法。

公开(公告)号：WO0009255A3

公开(公告)日：2000-11-23

申请号：PCT/US9918358

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC ,  TURNER HOWARD ,  DALES G CAMERON ,  ERDEN LYNN VAN ,  BEEK JOHANNES A M VAN ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G05B23/02 ,  G05D21/00 ,  G01K17/00 ,  G01L5/00 ,  G01L7/00 ,  G01N7/00 ,  G01N11/00 ,  G01N21/64 ,  G01N29/00

CPC classification number: G01N21/253 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  Y10T436/11

Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also for conventional experimental reactors as well. The apparatus generally includes multiple vessels (102, 206, 236, 266, 338, 362, 396, 522, 710, 876, 912, 1286, 1542) for containing reaction mixtures, and systems (180, 230, 260, 270, 272, 500, 1544, 1546, 1548, 1604) for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system (146, 1002) for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers (160, 268, 678, 720, 928, 1500, 1508, 1604), and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

Abstract translation: 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，而且对于常规实验反应器也是特别有用的。 该装置通常包括用于容纳反应混合物的多个容器（102,206,236,266,338,362,396,526,710,876,912,1286,1542）和系统（180,230,260,270,272 ，500,1544,1546,1548,1604），用于控制各个反应混合物或反应混合物组的搅拌速率和温度。 此外，该装置可以包括用于独立地控制每个容器中的压力的​​设备，以及用于以不同于环境压力的压力将液体注入到容器中的系统（146,1002）。 单独反应混合物的原位监测为过程控制器（160,268,678,720,928,1500,1508,1604）提供反馈，并且还提供用于确定反应速率，产物产率和反应产物的各种性质的数据， 包括粘度和分子量。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。