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公开(公告)号:CA2671866C
公开(公告)日:2014-03-25
申请号:CA2671866
申请日:2008-01-23
Applicant: TORAY INDUSTRIES
Inventor: NOMURA OSAMU , KURODA TOSHIHIKO , NOBUMASA HITOSHI , MURAO YASUO
IPC: C40B60/12 , C12Q1/68 , C40B30/04 , C40B40/00 , G01N33/543
Abstract: An analysis chip which has a baseboard having a selectively binding substance immobilized on the surface thereof, a covering member bonded to this baseboard and fine particles contained or injected in a movable state within a space that is formed between the baseboard and the covering member, wherein the surface of the fine particles is coated with a surfactant. Owing to this construction, it is possible to prevent the formation of bubbles inhibiting a selective reaction between a test substance and the selectively binding substance having been immobilized so that data variation and lowering in the sensitivity can be regulated and the reproducibility of the measurement can be elevated.
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公开(公告)号:CA2621060A1
公开(公告)日:2007-03-08
申请号:CA2621060
申请日:2006-09-01
Applicant: UNIV KYOTO , TORAY INDUSTRIES
Inventor: AKIYAMA HIDEO , TANAKA YOSHINORI , NOBUMASA HITOSHI , KOZONO SATOKO , TAKAHASHI TAKESHI , OGAWA OSAMU
IPC: C12Q1/68 , C12N15/09 , G01N33/53 , G01N33/566 , G01N33/574 , G01N37/00
Abstract: A method for detecting urothelial cancer comprising determining the expression of CXCL1 protein or a gene encoding the protein in a biological sample from a subject in vitro; and a kit for diagnosis of urothelial cancer comprising an antibody or nucleic acid probe capable of binding specifically to the protein or gene.
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公开(公告)号:CA2561909A1
公开(公告)日:2005-10-13
申请号:CA2561909
申请日:2005-03-29
Applicant: TORAY INDUSTRIES
Inventor: NOBUMASA HITOSHI , AKIYAMA HIDEO , JUNG GIMAN , KURODA SHUN ICHI , TANIZAWA KATSUYUKI
IPC: G01N33/544 , G01N33/554 , G01N33/576
Abstract: A substance sensing tool using hollow nanoparticles characterized in that a specified substance recognizing molecule is introduced in a protein capable of incorporating a lipid bilayer to thereby form nanosized particles. Further, there is provided a relevant sensing method.
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公开(公告)号:CA2559768A1
公开(公告)日:2005-09-29
申请号:CA2559768
申请日:2005-03-17
Applicant: TORAY INDUSTRIES
Inventor: TAKII YUKI , NAGINO KUNIHISA , NOBUMASA HITOSHI , NAKAMURA FUMIO
IPC: G01N35/02 , B01F33/40 , C12M1/02 , C12N15/09 , C12Q1/68 , G01N1/36 , G01N33/53 , G01N35/00 , G01N37/00
Abstract: The method of stirring a solution according to the present invention is a method of stirring a solution comprising contacting a selective binding substance immobilized on the surface of a carrier with a solution containing an analyte substance reactive with the selective binding substance, and mixing the fme particles or air bubbles into the solution containing an analyte substance, and moving the fine particles or air bubbles without allowing contact thereof with the selective binding substance-immobilized surface. The present invention provides a stirring method that accelerates the reaction of a carrier-immobilized selective binding substance with an analyte substance and detects a trace amount of analyte at high signal intensity and high S/N ratio. The present invention enables diagnosis and examination in the clinical setting by using a selective binding substance-immobilized carrier such as DNA chip.
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公开(公告)号:HK1010418A1
公开(公告)日:1999-06-17
申请号:HK98111069
申请日:1998-09-29
Applicant: TORAY INDUSTRIES
Inventor: OHBAYASHI GENTARO , NOBUMASA HITOSHI , HIROTA KUSATO , NAGINO KUNIHISA , AMIOKA TAKAO
IPC: G11B7/0045 , G11B7/005 , G11B7/0055 , G11B7/006 , G11B7/007 , G11B7/125 , G11B7/24 , G11B7/24079 , G11B7/243 , G11B7/253 , G11B7/2534 , G11B7/254 , G11B7/2542 , G11B7/257 , G11B7/258 , G11B7/2585 , G11B
Abstract: In an optical recording method, an edge type recording system is provided on an optical recording medium in which recording and erasing are effected by a phase change between amorphous and crystalline states. Recorded marks are provided by pulse trains each comprising a number of recording power pulses and, additionally, after the last of the recording power pulses, a pulse of from zero power to a power less than an erasing power and of a duration in a range 1.1 to 6 times the duration of the last recording power pulse or of a duration in a range 0.6 to 3 times the duration of a window margin.
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公开(公告)号:DK3159406T3
公开(公告)日:2021-01-11
申请号:DK15809775
申请日:2015-06-18
Applicant: TORAY INDUSTRIES , NAT CANCER CT
Inventor: SUDO HIROKO , NOBUMASA HITOSHI , KOZONO SATOKO , KONDOU SATOSHI , KAWAUCHI JUNPEI , OCHIAI ATSUSHI , KOJIMA MOTOHIRO
IPC: C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/574
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公开(公告)号:ES2727785T3
公开(公告)日:2019-10-18
申请号:ES04733682
申请日:2004-05-18
Applicant: TORAY INDUSTRIES
Inventor: NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
Abstract: Un soporte que tiene inmovilizada una sustancia de unión selectiva, donde el soporte tiene una parte con una depresión que incluye múltiples proyecciones, la superficie del soporte comprende una resina de autofluorescencia baja que tiene una intensidad de fluorescencia de 1.000 o menos, la superficie de la resina comprende grupos carboxilo formados mediante el tratamiento de la resina con un álcali o ácido, y adicionalmente se inmoviliza una sustancia de unión selectiva sobre las superficies superiores de las múltiples proyecciones de la parte con una depresión que incluye múltiples proyecciones mediante los grupos carboxilo de la resina, donde el soporte tiene formada un área plana, y la diferencia de altura entre la superficie superior plana de las proyecciones de la parte con una depresión que incluye múltiples proyecciones y la superficie del área plana es de 50 μm o menos. donde la intensidad de fluorescencia de la resina de autofluorescencia baja se determina midiendo una placa plana limpia que tiene un grosor de 1 mm utilizando un GenePix 4000B fabricado por Axon Instruments en condiciones de una longitud de onda de excitación de 532 nm, una ganancia de fotomultiplicador fijada en 700 y una potencia de láser del 33 %.
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公开(公告)号:CA2795436C
公开(公告)日:2017-12-05
申请号:CA2795436
申请日:2011-04-21
Applicant: TORAY INDUSTRIES
Inventor: KURODA TOSHIHIKO , NOMURA OSAMU , NOBUMASA HITOSHI
Abstract: The present invention provides a method for preparing aRNA to be used for gene expression analysis from an RNA sample extracted from a tissue or cell(s) fixed with a fixative, wherein, in an amplification step of the RNA sample by reverse transcription and in vitro transcription, the ratio of aminoallyl uridine 5'-triphosphate (AA-UTP) in a nucleotide reagent used in the in vitro transcription is not less than 5 mol% and less than 25 mol% with respect to the total of uridine 5'-triphosphate (UTP) and AA-UTP.
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公开(公告)号:PL2821794T3
公开(公告)日:2017-08-31
申请号:PL13755655
申请日:2013-02-27
Applicant: TORAY INDUSTRIES
Inventor: KURODA TOSHIHIKO , NOBUMASA HITOSHI
IPC: G01N35/02 , G01N33/53 , G01N33/543 , G01N37/00
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公开(公告)号:DK2607482T3
公开(公告)日:2017-07-03
申请号:DK11818210
申请日:2011-08-17
Applicant: TORAY INDUSTRIES
Inventor: YOSHIMOTO MAKIKO , AKIYAMA HIDEO , NOBUMASA HITOSHI
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