公开(公告)号：ZA201200722B

公开(公告)日：2013-05-29

申请号：ZA201200722

申请日：2012-01-30

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K20060101 ,  A61P20060101

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：AU2010282986A1

公开(公告)日：2012-02-16

申请号：AU2010282986

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：AU2009282419A2

公开(公告)日：2011-03-31

申请号：AU2009282419

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

公开(公告)号：ES2718273T5

公开(公告)日：2025-02-06

申请号：ES10708442

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K9/14 ,  A61K31/44 ,  A61K31/47 ,  A61K45/06 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

公开(公告)号：ME03356B

公开(公告)日：2019-10-20

申请号：MEP10119

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： VAN GOOR FREDRICK F ,  ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J

IPC: A61K31/44 ,  A61K9/14 ,  A61K31/47 ,  A61K45/06 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

公开(公告)号：LT2464337T

公开(公告)日：2019-05-10

申请号：LT10708442

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K9/14 ,  A61K31/44 ,  A61K31/47 ,  A61K45/06 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

公开(公告)号：LT2328618T

公开(公告)日：2018-03-26

申请号：LT09789125

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/47

公开(公告)号：EA021706B1

公开(公告)日：2015-08-31

申请号：EA201170330

申请日：2009-08-13

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K47/32

Abstract: Изобретениеотноситсяк областифармацевтики, аименнок таблетке, содержащейтвердуюдисперсию N-[2,4-бис-(1,1-диметилэтил)-5-гидроксифенил]-1,4-дигидро-4-оксохинолин-3-карбоксамидаи способуеевведения. Заявленнаятаблеткахарактеризуетсяхорошейрастворимостьюи высокойстабильностью.

公开(公告)号：NZ597823A

公开(公告)日：2014-05-30

申请号：NZ59782310

申请日：2010-02-18

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: A61K9/14 ,  A61K31/47 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00

Abstract: 597823 Disclosed herein are pharmaceutical compositions comprising a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1) for use treating or lessening the severity of cystic fibrosis in a patient, and method of manufacturing said compositions. In a preferred embodiment the patient possesses a cystic fibrosis transmembrane receptor (CFTR) with a &Dgr;F508 mutation or G551D mutation on both alleles.

公开(公告)号：HK1161140A1

公开(公告)日：2012-08-24

申请号：HK12102076

申请日：2012-02-29

Applicant: VERTEX PHARMA

Inventor： ROWE WILLIAM ,  HURTER PATRICIA ,  YOUNG CHRISTOPHER ,  DINEHART KIRK ,  VERWIJS MARINUS JACOBUS ,  OVERHOFF KIRK ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN ,  GROSSI ALFREDO

IPC: A61K20060101

Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.