公开(公告)号：IL257888D0

公开(公告)日：2018-05-31

申请号：IL25788818

申请日：2018-03-05

Applicant: MICELL TECHNOLOGIES INC ,  WENDA C CARLYLE

Inventor： WENDA C CARLYLE

IPC: A61K20060101

Abstract: Drug delivery systems are disclosed which include a drug in dry powder form and a biodegradable or metabolizable carrier having an average particle size of less than about 1 mm for delivery of the drug to a particular location in the body and for providing for the timed elution of the drug at that location, preferably by exhibiting a linear drug elution profile for a sustained drug release period of at least 30 days. Methods for manufacturing these drug delivery systems are also disclosed.

公开(公告)号：AU2017219090A1

公开(公告)日：2018-04-12

申请号：AU2017219090

申请日：2017-08-25

Applicant: MICELL TECHNOLOGIES INC

Inventor： KIORPES TIMOTHY CHARLES ,  MCCLAIN JAMES B

IPC: A61L27/28 ,  A61K31/00 ,  A61K38/00 ,  A61K47/00

Abstract: A drug-eluting product is disclosed comprising an at least partially bioabsorbable element and an active pharmaceutical agent having a morphology, a solubility, and an average particle size which are selected so that the active pharmaceutical agent continues to dissolve during the biodegradation of the bioabsorbable element. The morphology is a crystalline, semi-crystalline or amorphous morphology, the solubility is less than 100 ptg/ml and the average particle size is grater that about 100 nm.

公开(公告)号：CA2650590C

公开(公告)日：2018-04-03

申请号：CA2650590

申请日：2007-04-26

Applicant: MICELL TECHNOLOGIES INC

Inventor： DEYOUNG JAMES ,  TAYLOR DOUG ,  MCCLAIN JIM ,  SMOKE CLINT ,  COLE MIKE

IPC: A61L31/16 ,  A61F2/82 ,  A61K31/436 ,  A61L31/12 ,  A61L31/14 ,  A61M31/00

Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

公开(公告)号：AU2017210510A1

公开(公告)日：2017-08-17

申请号：AU2017210510

申请日：2017-08-01

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  FAGAN MEAGAN M

IPC: A61M31/00

Abstract: Abstract A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

公开(公告)号：AU2012326010B2

公开(公告)日：2017-05-11

申请号：AU2012326010

申请日：2012-10-18

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR CHARLES DOUGLAS ,  FAGAN MEGAN M

IPC: A61M31/00

Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

公开(公告)号：ZA201007405B

公开(公告)日：2017-04-26

申请号：ZA201007405

申请日：2010-10-15

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

公开(公告)号：CA2613280C

公开(公告)日：2016-05-10

申请号：CA2613280

申请日：2006-06-21

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  DEYOUNG JAMES P

IPC: A61K9/00 ,  A61F13/00 ,  A61K9/20 ,  A61K9/48

Abstract: A method of forming a drug/polymer composite material is carried out by combining a drug material with a polymer material under pressure in the presence of a densified gas solvent (e.g., carbon dioxide) to form the drug/polymer composite material. Drug/polymer composite materials and shaped articles (e.g., subcutaneous drug depots) which may be produced by a process are also described, along with methods of use thereof.

公开(公告)号：AU2014265460A1

公开(公告)日：2015-12-17

申请号：AU2014265460

申请日：2014-05-15

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B

IPC: A61F2/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/90 ,  A61F2/92 ,  A61L31/12

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 150 μm. Methods for making the bioabsorbable biomedical implant, including the methods for making the fiber-reinforced polymer composite materials for the tubular scaffold, are also disclosed.

公开(公告)号：CA2912387A1

公开(公告)日：2014-11-20

申请号：CA2912387

申请日：2014-05-15

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B

IPC: A61F2/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/90 ,  A61F2/92 ,  A61L31/12

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 150 µm. Methods for making the bioabsorbable biomedical implant, including the methods for making the fiber-reinforced polymer composite materials for the tubular scaffold, are also disclosed.

公开(公告)号：SG192524A1

公开(公告)日：2013-08-30

申请号：SG2013054127

申请日：2009-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.FIGURE 22