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公开(公告)号：US11986498B2
公开(公告)日：2024-05-21
申请号：US14056101
申请日：2013-10-17
Applicant: Osiris Therapeutics, Inc.
Inventor： Timothy Jansen , Samson Tom , Alla Danilkovitch , Dana Yoo , Jaime Zerhusen
CPC classification number: A61K35/28 , A01N1/0221 , A61K35/50 , A61K38/1825 , A61K38/1841 , A61K38/39 , A61K38/57 , C12N5/0605 , C12N2500/02 , C12N2501/115 , C12N2502/025
Abstract: This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20230128936A1
公开(公告)日：2023-04-27
申请号：US17971980
申请日：2022-10-24
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US11510947B2
公开(公告)日：2022-11-29
申请号：US16736066
申请日：2020-01-07
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US20220202991A1
公开(公告)日：2022-06-30
申请号：US17698602
申请日：2022-03-18
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Thomas E. UVEGES , Jin-Qiang KUANG , Alla DANILKOVITCH , S. Michael SINCLAIR , Sandra D. GERAGHTY
Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
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45.发明申请公开(公告)号：US20220202876A1
公开(公告)日：2022-06-30
申请号：US17698490
申请日：2022-03-18
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Steven Michael SINCLAIR , Alla DANILKOVITCH , Malathi SATHYAMOORTHY , Jin-Qiang KUANG , Sandeep DHALL , Anthony John MELCHIORRI
Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.
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Patent Agency Ranking
公开(公告)号：US10994913B2
公开(公告)日：2021-05-04
申请号：US16279413
申请日：2019-02-19
Applicant: OSIRIS THERAPEUTICS, INC.
Inventor： Yi Duan-Arnold , Alla Danilkovitch , Alexandra Gyurdieva , Jin-Qiang Kuang , Steven Michael Sinclair
IPC: B65D77/26 , B65D65/02 , B65D85/00 , B65B5/04 , B65B55/22 , A61F2/00 , A61F15/00 , A61F2/10 , A61B90/00
Abstract: A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.
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公开(公告)号：US20210023268A1
公开(公告)日：2021-01-28
申请号：US17039402
申请日：2020-09-30
Applicant: Osiris Therapeutics, Inc.
Inventor： Thomas E. UVEGES , Jin-Qiang KUANG , Alla DANILKOVITCH , S. Michael SINCLAIR , Sandra D. GERAGHTY
Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
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公开(公告)号：US10272116B2
公开(公告)日：2019-04-30
申请号：US14172940
申请日：2014-02-05
Applicant: Osiris Therapeutics, Inc.
Inventor： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
Abstract: Provided herein is a placental product comprising an immunocompatible amniotic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：USD844150S1
公开(公告)日：2019-03-26
申请号：US29587466
申请日：2016-12-13
Applicant: OSIRIS THERAPEUTICS, INC.
Designer： Yi Duan-Arnold , Alexandra Gyurdieva
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公开(公告)号：US20170035935A1
公开(公告)日：2017-02-09
申请号：US15298142
申请日：2016-10-19
Applicant: Osiris Therapeutics, Inc.
Inventor： Thomas E. UVEGES , Jin-Qiang KUANG , Alla DANILKOVITCH , S. Michael SINCLAIR , Sandra D. GERAGHTY
Abstract: Provided herein is a bone repair composition that is composed of periosteum containing an angiogenic growth factor(s), cancellous bone chips containing viable osteogenic cells, and, optionally, demineralized bone matrix (DBM) chips. Also provided herein are articles of manufacture and methods of use thereof to treat bone defects.
Abstract translation: 本文提供了一种骨修复组合物，其由含有血管生成生长因子的骨膜，含有活的成骨细胞的松质骨碎片和任选的软化骨基质（DBM）芯片组成。 本文还提供了治疗骨缺损的制品及其使用方法。
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