公开(公告)号：EP2903970A4

公开(公告)日：2016-11-30

申请号：EP13845144

申请日：2013-10-08

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  PANDEY ANJALI

IPC: C07D239/02 ,  A61K31/444 ,  A61K31/506 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

CPC classification number: C07D405/14 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

Abstract: Provided are substituted pyrimidinyl compounds for inhibition of JAK and/or Syk kinase, pharmaceutical compositions thereof, methods for inhibiting JAK and/or Syk kinase activity, and methods for treating conditions mediated at least in part by JAK and/or Syk kinase activity.

公开(公告)号：EP2900243A4

公开(公告)日：2016-04-13

申请号：EP13840922

申请日：2013-09-27

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  SONG YONGHONG ,  XU QING

IPC: A61K31/5365 ,  A61P11/00 ,  C07D498/04

CPC classification number: C07D498/04

公开(公告)号：EP2782579A4

公开(公告)日：2015-08-26

申请号：EP12852197

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  A61K31/4965 ,  A61P7/00 ,  A61P9/00 ,  A61P31/00 ,  A61P33/00 ,  A61P37/00 ,  C07D401/12 ,  C07D417/12

CPC classification number: C07D241/28 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: Provided are substituted pyrazine-2-carboxamide compounds of Formula I: useful for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

Abstract translation: 提供式I的取代吡嗪-2-甲酰胺化合物：可用于抑制Syk激酶，用于制备此类化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法和用于治疗在 至少部分由Syk激酶活性。

公开(公告)号：EP2146573A4

公开(公告)日：2012-11-21

申请号：EP08747595

申请日：2008-05-02

Applicant: PORTOLA PHARM INC

Inventor： STEPHENS GILLIAN ,  GAO DACAO ,  ANDRE PATRICK ,  PHILLIPS DAVID R

IPC: A61K31/444 ,  A61K45/06 ,  A61P9/00

CPC classification number: A61K31/422 ,  A61K31/20 ,  A61K31/405 ,  A61K31/4406 ,  A61K31/444 ,  A61K45/06

公开(公告)号：EP1812429A4

公开(公告)日：2010-07-21

申请号：EP05798632

申请日：2005-09-26

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  VENKATRAMAN MEENAKSHI S ,  ZHANG XIAOMING ,  PANDEY ANJALI

IPC: C07D413/12 ,  A61K31/536 ,  C07D413/14

CPC classification number: C07D413/12 ,  C07D413/14

公开(公告)号：IL277093D0

公开(公告)日：2020-10-29

申请号：IL27709320

申请日：2020-09-01

Applicant: PORTOLA PHARM INC ,  ORA INC

IPC: A61K9/00 ,  A61K9/08 ,  A61K31/506 ,  A61K47/10 ,  A61P27/14

Abstract: Provided herein are methods of using Syk inhibitors, such as a selective Syk inhibitor, Compound 1 or a pharmaceutically acceptable salt thereof, in treating allergic and/or inflammatory diseases or conditions of the eye. Also provided is pharmaceutical compositions, in particular eyedrop ophthalmic compositions, comprising Compound 1 or a pharmaceutically acceptable salt thereof, useful in the methods.

公开(公告)号：NO2020033I1

公开(公告)日：2020-09-23

申请号：NO2020033

申请日：2020-09-23

Applicant: PORTOLA PHARM INC ,  ALEXION PHARMA INC

IPC: C12N9/64 ,  A61K38/48 ,  A61K39/00 ,  A61P7/04

公开(公告)号：SI3078743T1

公开(公告)日：2020-08-31

申请号：SI200832130

申请日：2008-09-26

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  PHILLIPS DAVID R ,  ANDRE PATRICK ,  SINHA UMA

IPC: C12N9/00 ,  A61K38/00 ,  A61K39/00 ,  A61P7/00

公开(公告)号：ZA201408921B

公开(公告)日：2020-08-26

申请号：ZA201408921

申请日：2014-12-04

Applicant: PORTOLA PHARM INC

Inventor： LU GENMIN ,  SINHA UMA

Abstract: Disclosed herein are methods and kits for purifying a serine protease. The methods entail loading the serine protease to a soybean trypsin inhibitor (STI) based affinity chromatograph, and eluting the serine protease with an elution buffer comprising an agent that disrupts interaction between the STI and the serine protease.

公开(公告)号：IL272926D0

公开(公告)日：2020-04-30

申请号：IL27292620

申请日：2020-02-26

Applicant: PORTOLA PHARM INC

IPC: A61K20060101 ,  A61K39/00

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa.The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.