Abstract:
PURPOSE: A composition containing Potentilla chinensis extract for tightening pore or suppressing sebum secretion is provided to suppress SNARE(soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex formulation. CONSTITUTION: A composition for tightening pore or suppressing sebum contains Potentilla chinensis extract as an active ingredient. The composition suppresses membrane fusion between synaptic vesicle and presynaptic membrane. The Potentilla chinensis extract isolated using water, ethanol, or anhydrous methanol. A pharmaceutical composition or a cosmetic composition contains the composition. The cosmetic composition is manufactured in the form of astringent, lotion, massage cream, essence, cleansing cream, cleansing foam, cleansing water, pack, powder, body lotion, body cream, or body essence.
Abstract:
본 발명은 유사세라마이드 및 스테아린산을 포함하는 유사지질 복합체 및 이를 함유하는 피부 외용제 조성물에 관한 것이다. 본 발명의 복합체는 상안정도가 매우 우수하고 다량의 수분 및 유용 활성 물질을 담지할 수 있는 피부 각질층과 유사한 구조를 제공하므로, 이를 포함하는 조성물은 피부에 도포시 우수한 피부 보습효과 및 장벽기능회복을 나타내는 피부 외용제 조성물로 이용될 수 있다. 유사세라마이드, 스테아린산, 콜레스테롤, 피부 외용제 조성물, 보습, 피부장벽
Abstract:
PURPOSE: A composition containing polyphenol compounds for pore tightening is provided to suppress complex formation of SNARE(soluble Nethylmaleimide-sensitive factor attachment protein receptor). CONSTITUTION: A composition for pore tightening contains 0.0001-30 weight% of polyphenol compounds as active ingredients. The polyphenol compounds are myricetin, quercetin, luteolin, delphinidin, cyaniding, butein, ellagic acid, EGCG(Epigallocatechin gallate), fisetin, derivative thereof. An external use skin composition contains the composition for pore tightening. The external use skin composition is a percutenous formulation. A pharmaceutical composition or cosmetic composition contains the composition for pore tightening.
Abstract:
PURPOSE: A cosmetic composition for anti-irritation is provided to safely and continuously reduce skin irritation. CONSTITUTION: A cosmetic composition for anti-irritation contains Rhodiola Sachalinensis A. Bor extract, beta carotene, tocopherol, or extremophile fermentation. The extremophile fermentation is Thermus thermophilus fermentation. The Rhodiola Sachalinensis A. Bor extract, beta carotene, tocopherol, or extremophile fermentation is contained within 0.01-50.0 weight% based on total weight. The cosmetic composition is used in the form of a lotion, essence, cream, pack, UV protecting agent, foundation, or lip stick.
Abstract:
본 발명은 하기 화학식 1로 표시되는 2,4,5-삼중치환-1,3-티아졸 유도체 및 약제학적으로 허용 가능한 그의 염, 그의 제조방법 및 그를 유효성분으로 함유하는 SPC 수용체 활성으로 유발되는 염증관련 질환에 유용한 그의 용도에 관한 것이다. 본 발명의 2,4,5-삼중치환-1,3-티아졸 유도체는 사람으로부터 유래된 진피세포 및 마우스를 이용한 동물실험을 통하여 항염증 효과를 검색한 결과, SPC 수용체에 대한 우수한 억제활성을 규명함으로써, 상기 2,4,5-삼중치환-1,3-티아졸 유도체 및 약제학적으로 허용 가능한 그의 염을 유효성분으로 함유하여 SPC 수용체 활성으로 유발되는 아토피성 피부염, 기타 질환에서 나타나는 염증, 소양증 또는 피부 감염증에 유효한 염증관련 질환 치료제로서 유용하게 활용될 수 있다.
(상기 식에서, R 1 , R 2 , 및 R 3 는 명세서에서 정의한 바와 같다.) 1,3-티아졸, 스핀고실포스포릴콜린, 아토피 피부염, 염증치료제
Abstract:
Provided is a 3-chloro-5-substituted-quinoxaline-2-amine derivative and a therapeutic agent using the 3-chloro-5-substituted-quinoxaline-2-amine derivative so as to treat diseases associated with inflammation. A 3-chloro-5-substituted-quinoxaline-2-amine derivative is represented by the formula 1. In the formula 1, R∧1 indicates hydrogen, linear or branched C1-C10 alkyl group, C1-C10 alkoxy group or halogen; R∧2 shows linear or branched C1-C10 alkyl group, C1-C10 alkoxy group, hydroxyl group, halogen group, amine group or substituted amine group, amide group, carbamate group or urea group. In the formula 1, the substituted group indicates a substituted phenyl group wherein one or four groups selected from the group consisting of a linear or branched C1-C10 alkyl group, halogen, nitro group, C1-C10 alkyl group, C1-C10 alkoxy group and C1-C10 haloalkyl group are substituted.