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公开(公告)号：KR1020140048404A
公开(公告)日：2014-04-24
申请号：KR1020120113188
申请日：2012-10-11
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61K47/48907 , A61K9/1271 , A61K9/1272 , A61K9/1275 , A61K49/1839 , A61K51/0493 , A61K51/1251 , C12N15/111 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2320/30 , C12N2320/32 , A61K9/16 , A61K47/30 , A61K47/50 , A61K49/08
Abstract: The present invention relates to low-density lipoprotein like cationic lipid nanoparticles in solid form which target liver cells including parenchyma cells and non-parenchyma cells forming the liver tissue; and a composition comprising the same for liver-targeted delivery of a composition for diagnosing and/or treating liver diseases.
Abstract translation: 本发明涉及固体形式的低密度脂蛋白，如阳离子脂质纳米粒子，靶向肝细胞，包括形成肝组织的实质细胞和非实质细胞; 以及包含其用于肝靶向递送用于诊断和/或治疗肝脏疾病的组合物的组合物。
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公开(公告)号：KR1020130131227A
公开(公告)日：2013-12-03
申请号：KR1020130047574
申请日：2013-04-29
Applicant: 포항공과대학교 산학협력단
IPC: A61K9/16 , A61K47/40 , A61K31/721 , A61K31/727
CPC classification number: A61K38/212 , A61K38/177 , A61K38/1833 , A61K47/61 , A61K47/6923 , A61K9/16 , A61K9/20 , A61K31/721 , A61K47/40
Abstract: The present invention relates to a liver targetted drug delivery system using metal nanoparticles and a method for preparing the same. More specifically, the present invention relates to a method for preparing hyaluronic acid-gold nanoparticle / protein composites which surface-modify gold nanoparticles with enhanced in vivo stability using hyaluronic acid which has biocompatibility, biodegradability, and specific delivery properties for liver tissues and attaches various protein medicines for treating liver complaint to the surfaces of residual gold nanoparticles in order to be used as the liver targetted drug delivery system, and to a composition. In addition, the present invention relates to applications of an agent for treating liver complaint which can be safely applied in human body using the hyaluronic acid-gold nanoparticle / protein composites and increases medicinal effect time and is effectively delivered to liver.
Abstract translation: 本发明涉及使用金属纳米粒子的肝靶向药物递送系统及其制备方法。 更具体地说，本发明涉及一种制备透明质酸 - 金纳米颗粒/蛋白质复合物的方法，该透明质酸 - 金纳米颗粒/蛋白质复合物使用具有生物相容性，生物降解性和肝组织的特异性递送性质的透明质酸表面改性金纳米颗粒增强体内稳定性并附着各种 用于将肝脏投诉用于肝脏靶向药物递送系统的残余金纳米颗粒的表面的蛋白质药物以及组合物。 此外，本发明涉及可以使用透明质酸 - 金纳米颗粒/蛋白质复合物安全地应用于人体的肝脏投诉的药物的应用，并且增加药物作用时间并且有效地递送至肝脏。
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43.发明公开
公开(公告)号：KR1020110076469A
公开(公告)日：2011-07-06
申请号：KR1020090133187
申请日：2009-12-29
Applicant: 포항공과대학교 산학협력단
IPC: A61K9/22 , A61K47/30 , A61K39/395 , A61P35/00
CPC classification number: A61K9/20 , A61K39/395 , A61K47/38 , B82Y5/00
Abstract: PURPOSE: A method for preparing a self-assembled drug and a cell delivery system is provided to easily synthesize a polymer composite and to prepare a drug and cell delivery system. CONSTITUTION: A method for preparing a self-assembled drug and a cell delivery system comprises a step of mixing: a compound of chemical formula I([B]m-[H]n); a drug, fluorescent substance, radioactive isotope, target oriented material, or imaging material which interacts with the compound of chemical formula I; and a functional group which interacts with the compound of chemical formula I in a solvent. The solvent is water, saline solution, buffer solution, or ethanol. The self-assembled delivery system is a hydrogel.
Abstract translation: 目的：提供一种制备自组装药物和细胞递送系统的方法，以容易地合成聚合物复合物并制备药物和细胞递送系统。 构成：制备自组装药物和细胞递送系统的方法包括混合化学式I（[B] m- [H] n）的化合物; 与化学式I化合物相互作用的药物，荧光物质，放射性同位素，靶向材料或成像材料; 以及在溶剂中与化学式I的化合物相互作用的官能团。 溶剂为水，盐水溶液，缓冲溶液或乙醇。 自组装输送系统是水凝胶。
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公开(公告)号：KR101041985B1
公开(公告)日：2011-06-16
申请号：KR1020090085832
申请日：2009-09-11
Applicant: 포항공과대학교 산학협력단
Abstract: 본 발명은 핵산 전달용 고분자의 제조방법 및 상기 고분자를 함유하는 핵산 전달용 조성물에 관한 것으로, 구체적으로 핵산을 세포 내로 효과적으로 전달하고 독성이 거의 없는 핵산 전달용 고분자의 제조방법 및 상기 고분자를 함유하는 핵산 전달용 조성물에 관한 것이다. 본 발명의 핵산 전달용 고분자의 제조방법 및 상기 고분자를 함유하는 핵산 전달용 조성물은 핵산을 세포 내로 효과적으로 전달할 수 있고 독성이 거의 없어, 핵산의 효과적인 전달 시스템으로 활용할 수 있으며, 특히 저 분자량으로 분해되는 폴리에틸렌이민과 생체적합성이 우수한 히알루론산이 함유되어 주사 제형 및 비강 등을 통해 효과적으로 핵산을 전달할 수 있다.
핵산, 전달, 히알루론산, 폴리에틸렌이민, 스퍼민-
45.发明公开약물 전달체의 표적 특이성 조절 방법, 표적 특이적 약물 전달체, 및 표적-비특이적 약효 장기 지속성 약물 전달체 无效控制目标特异性药物递送的方法，目标特异性药物递送系统和目标非特异性长效药物递送系统
公开(公告)号：KR1020110032561A
公开(公告)日：2011-03-30
申请号：KR1020090090113
申请日：2009-09-23
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61K47/36 , A61K47/61 , A61K49/0054 , A61K49/0067
Abstract: PURPOSE: A method for controlling target-specificity of a drug delivery system containing a hyaluronic acid derivative is provided to control carboxyl group substitution rate. CONSTITUTION: A target specificity of a drug delivery system containing hyaluronic acid derivatives is controlled by regulating carboxyl group substitution rate of hyaluronic acid derivatives. A target receptor of the drug delivery system is CD44, LYVE-1, RHAMM, or HARE. The drug delivery system contains hyaluronic acid derivatives in which 5 mole%-45mole% of substituted carboxyl group. The drug delivery system contains encapsulated or sealed drug for preventing or treating liver diseases.
Abstract translation: 目的：提供一种控制含有透明质酸衍生物的药物递送系统靶特异性的方法，以控制羧基取代率。 构成：通过调节透明质酸衍生物的羧基取代率来控制含有透明质酸衍生物的药物递送系统的靶特异性。 药物递送系统的靶受体是CD44，LYVE-1，RHAMM或HARE。 药物递送系统含有5mol％-45mol％的取代羧基的透明质酸衍生物。 药物递送系统包含用于预防或治疗肝脏疾病的包封或密封药物。
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Patent Agency Ranking
公开(公告)号：KR1020110027969A
公开(公告)日：2011-03-17
申请号：KR1020090085832
申请日：2009-09-11
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61K47/36 , A61K31/7105 , A61K47/34 , A61K2121/00
Abstract: PURPOSE: A method for preparing polymers for nucleic acid delivery is provided to transfer nucleic acid through injection or nasal cavity. CONSTITUTION: A polymer for nucleic acid delivery is prepared by binding hyaluronic acid and disulfide bond-introduced polyethyleneimine. A method for preparing the polymers comprises: a step of adding 1-ethyl-3- [3-(dimethylamino)-propyl]carbodiimide, N, N'-dicyclohexylcarbodiimide(DCC), 1-hydroxy bentriazole monohydrate(HOBt), or N-hydroxysuccinimide(NHS) compound to hyaluronic acid; and a step of binding polyethylene imine in disulfide bond is introduce. A composition for nucleic acid delivery contains polymer of chemical formula 1 or 2.
Abstract translation: 目的：提供用于制备用于核酸递送的聚合物的方法以通过注射或鼻腔转移核酸。 构成：用于核酸递送的聚合物通过结合透明质酸和引入二硫键的聚乙烯亚胺制备。 制备聚合物的方法包括：加入1-乙基-3- [3-（二甲基氨基） - 丙基]碳二亚胺，N，N'-二环己基碳二亚胺（DCC），1-羟基吡唑一水合物（HOBt）或N - 羟基琥珀酰亚胺（NHS）化合物至透明质酸; 并引入结合二硫键中的聚乙烯亚胺的步骤。 用于核酸递送的组合物含有化学式1或2的聚合物。
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公开(公告)号：KR1020100133688A
公开(公告)日：2010-12-22
申请号：KR1020090052371
申请日：2009-06-12
Applicant: 포항공과대학교 산학협력단
Abstract: PURPOSE: A method for preparing hyaluronic acid-peptide conjugate is provided to apply to a drug delivery system of various peptide active ingredients with safety to human body. CONSTITUTION: A method for preparing hyaluronic acid-peptide conjugate comprises: a step of reacting tetra-n-butyl ammonium hydroxide(TBA-OH) with hyaluronic acid(HA), salt thereof, derivative thereof to form HA-TBA; a step of preparing water-insoluble peptide with terminal amino group; and a step of reacting the water-insoluble peptide with HA-TBA and terminal amino group under the presence of organic solvent.
Abstract translation: 目的：提供一种制备透明质酸 - 肽缀合物的方法，适用于对人体有安全性的各种肽活性成分的药物递送系统。 构成：制备透明质酸 - 肽缀合物的方法包括：使四正丁基氢氧化铵（TBA-OH）与透明质酸（HA）及其盐，其衍生物反应形成HA-TBA的步骤; 用末端氨基制备水不溶性肽的步骤; 以及在有机溶剂的存在下使水不溶性肽与HA-TBA和末端氨基反应的步骤。
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公开(公告)号：KR1020100130773A
公开(公告)日：2010-12-14
申请号：KR1020090049465
申请日：2009-06-04
Applicant: 포항공과대학교 산학협력단
CPC classification number: C08B37/0072 , C08B15/10 , C12N11/04
Abstract: PURPOSE: An X-ray ablation method of hyaluronan hydrogel is provided to obtain a new protocol for manufacturing HA-system hydrogel by the short light X-ray irradiation. CONSTITUTION: An X-ray ablation method of hyaluronan hydrogel comprises the following steps: preparing hyaluronan hydrogel; and irradiating X-rays to the hyaluronan hydrogel for inducing the decomposition of the hyaluronan hydrogel through the gel-sol transition. The decomposition speed of the hyaluronan hydrogel is determined by the dose of the X-ray irradiation.
Abstract translation: 目的：提供透明质酸水凝胶的X射线消融方法，以获得通过短光X射线照射制造HA系统水凝胶的新方案。 构成：透明质酸水凝胶的X射线消融法包括以下步骤：制备透明质酸水凝胶; 并向透明质酸水凝胶照射X射线，以通过凝胶 - 溶胶转变诱导透明质酸水凝胶的分解。 透明质酸水凝胶的分解速度由X射线照射的剂量决定。
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49.发明公开혈관성장인자 감지를 위한 압타머 기반의 암 진단용 실리콘나노와이어 바이오센서, 이의 제조방법 및 이를 이용한 혈관 성장인자 검출방법 失效基于APTAMER的硅纳米生物传感器，用于根据VEGF的检测进行的癌症诊断及其制造方法和使用该方法检测VEGF
公开(公告)号：KR1020100045831A
公开(公告)日：2010-05-04
申请号：KR1020080104946
申请日：2008-10-24
Applicant: 포항공과대학교 산학협력단
IPC: G01N33/50 , G01N27/26 , G01N33/68 , G01N33/574
Abstract: PURPOSE: A silicon nanowire biosensor for diagnosing cancer is provided to selectively detect vascular endothelial growth factor(VEGF) and early diagnose various kinds of cancer. CONSTITUTION: A silicon nanowire transistor biosensor contains source, drain, gate, a field effect transistor having a channel area between the source and drain, and an RAN aptamer which selectively binds with fixed VEGF on the surface of silicon nano wire. The RNA aptamer is Pegaptanib Sodium.
Abstract translation: 目的：提供用于诊断癌症的硅纳米线生物传感器，以选择性检测血管内皮生长因子（VEGF）并早期诊断各种癌症。 构造：硅纳米线晶体管生物传感器包含源极，漏极，栅极，具有源极和漏极之间的沟道区域的场效应晶体管，以及选择性地与硅纳米线表面上的固定VEGF结合的RAN适体。 RNA适体是哌加他滨钠。
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公开(公告)号：KR1020090112967A
公开(公告)日：2009-10-29
申请号：KR1020080038777
申请日：2008-04-25
Applicant: 주식회사 메가젠임플란트 , 포항공과대학교 산학협력단
CPC classification number: A61L27/58 , A61L27/20 , A61L27/52 , A61L24/08 , A61L27/40 , A61L27/44 , A61L27/46 , C08L5/08
Abstract: PURPOSE: A hyaluronate bone filling complex and a method for fabricating the same are provided, which obtain excellent reproduction capacity. CONSTITUTION: A hyaluronate bone filling complex comprises a matrix including hyaluronic acid derivative of the hydrogel form and a bone reproduction derivative which is filled in the matrix. The bone reproduction derivative is bone reproduction derivative synthesized by megagen. The bone reproduction derivative is chemical deposition reactant of biphasic calcium phosphate which includes tricalcium phosphate and hydroxyapatite or calcium nitrate tetrahydrate and dibasic ammonium phosphate.
Abstract translation: 目的：提供透明质酸骨填充复合物及其制造方法，其具有优异的再生能力。 构成：透明质酸骨填充复合物包括包含水凝胶形式的透明质酸衍生物的基质和填充在基质中的骨再生衍生物。 骨再生衍生物是由megagen合成的骨再生衍生物。 骨再生衍生物是磷酸二钙和羟基磷灰石或四水合硝酸钙四水合磷酸二钙的化学沉积反应物。
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