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公开(公告)号：KR101438532B1
公开(公告)日：2014-09-12
申请号：KR1020120089402
申请日：2012-08-16
Applicant: 한국과학기술연구원
Abstract: 본 발명은 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물 및 이를 스크리닝하는 방법에 관한 것이다. 일 구체예에 따른 퇴행성 뇌질환의 예방 또는 치료용 후보 물질의 스크리닝 방법에 의하면, 퇴행성 뇌질환의 예방 또는 치료 물질을 효과적으로 스크리닝할 수 있으며, 이에 따른 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물은 여러 퇴행성 뇌질환을 효과적으로 예방 또는 치료할 수 있다.
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公开(公告)号：KR1020140025902A
公开(公告)日：2014-03-05
申请号：KR1020120092441
申请日：2012-08-23
Applicant: 한국과학기술연구원
IPC: C07D333/20 , C07D333/40 , A61K31/381 , A61P19/10
Abstract: The present invention relates to a novel compound which is useful for blocking a calcium-dependent chloride channel and, more specifically, to a chemical compound or a pharmaceutically approved salt compound thereof, which is presented in chemical formula 1. In chemical formula 1, X stands for -S- or -C=C-; R1 stands for a hydrogen atom, a halogen atom, a nitro group, a C1-C6 alkyl group, or a C1-C6 haloalkyl group; R2 stands for a substituted or non-substituted phenyl group or a substituted or non-substituted naphthyl group, substituted by one to three groups chosen among halo, nitro, C1-C6 alkyl, C1-C6 alkoxy, and C1-C6 haloalkyl groups. However, when the X stands for -C=C-, a compound whose R2 is substituted or not substituted phenyl group is excluded.
Abstract translation: 本发明涉及一种可用于阻断钙依赖性氯离子通道的新化合物，更具体地说，涉及化学式1中所示化学化合物或其药学上认可的盐化合物。在化学式1中，X 代表-S-或-C = C-; R1代表氢原子，卤素原子，硝基，C1-C6烷基或C1-C6卤代烷基; R2代表取代或未取代的苯基或被一至三个选自卤素，硝基，C 1 -C 6烷基，C 1 -C 6烷氧基和C 1 -C 6卤代烷基的基团取代或未取代的萘基。 然而，当X代表-C = C-时，不包括其R2为取代或未取代的苯基的化合物。
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公开(公告)号：KR1020130103461A
公开(公告)日：2013-09-23
申请号：KR1020130092770
申请日：2013-08-05
Applicant: 한국과학기술연구원
IPC: C07D403/06 , C07D403/12 , A61K31/497 , A61P25/00
Abstract: PURPOSE: A phenoxypropanol derivative is provided to effectively suppress T-type calcium channel or TWIK-related K+ (TREK)-1 channel, thereby treating various diseases caused by the activation of the channels. CONSTITUTION: A phenoxypropanol derivative of chemical formula I or a racemic body, a pharmaceutically acceptable salt, a solvate, or a hydrate thereof is provided. A pharmaceutical composition for preventing or treating diseases related to T-type calcium channel or TREK-1 channel, selected among Parkinson's disease, Alzheimer's disease, schizophrenia, sleep disorder, epilepsy, pain, hypertension, arrhythmia, ventricular hypertrophy, angina pectoris, heart failure, myocardial infarction, cancer, hypoxia, cerebral ischemia, alkalemia, and depression contains the phenoxypropanol derivative, the racemic body, the pharmaceutically acceptable salt, the solvate, or the hydrate as an active ingredient. A method for suppressing T-type calcium channel or TREK-1 channel comprises the steps of: preparing a biological sample from an organ; and applying the phenoxypropanol derivative, the racemic body, the pharmaceutically acceptable salt, the solvate, or the hydrate to the biological sample.
Abstract translation: 目的：提供苯氧基丙醇衍生物，有效抑制T型钙通道或TWIK相关K +（TREK）-1通道，从而治疗由通道激活引起的各种疾病。 构成：提供化学式I的苯氧基丙醇衍生物或外消旋体，其药学上可接受的盐，溶剂化物或其水合物。 用于预防或治疗与帕金森病，阿尔茨海默病，精神分裂症，睡眠障碍，癫痫，疼痛，高血压，心律失常，心室肥大，心绞痛，心力衰竭有关的T型钙通道或TREK-1通道相关疾病的药物组合物 ，心肌梗死，癌症，缺氧，脑缺血，碱血症和抑郁症含有苯氧基丙醇衍生物，外消旋体，药学上可接受的盐，溶剂合物或水合物作为活性成分。 抑制T型钙通道或TREK-1通道的方法包括以下步骤：从器官制备生物样品; 以及将所述苯氧基丙醇衍生物，外消旋体，药学上可接受的盐，溶剂合物或水合物施用于生物样品。
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公开(公告)号：KR1020130060799A
公开(公告)日：2013-06-10
申请号：KR1020110127053
申请日：2011-11-30
Applicant: 한국과학기술연구원
IPC: C07D403/06 , A61K31/496 , A61P25/00
CPC classification number: C07D295/15 , C07D211/22 , C07D211/38 , C07D211/52 , C07D211/58 , C07D231/40 , C07D233/64 , C07D295/088 , C12N5/0686 , C12N2501/999
Abstract: PURPOSE: A phenoxy propanol derivative is provided to effectively suppress T-type calcium channel or TREK(TWIK-related K+)-1 channel and to treat various diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating diseases related to T-type calcium channel or TREK-1 channel contains a phenoxy propanol derivative with a structure of chemical formula I or a racemic body, a pharmaceutically acceptable salt, solvent, or hydrate thereof as an active ingredient. A method for suppressing the T-type calcium channel or TREK-1 channel comprises: a step of preparing a biological sample from organism; and a step of applying the phenoxy propanol derivative, or a racemic body, a pharmaceutically acceptable salt, solvate, or hydrate thereof.
Abstract translation: 目的：提供苯氧丙醇衍生物，有效抑制T型钙通道或TREK（TWIK相关K +）-1通道，治疗各种疾病。 构成：用于预防或治疗与T型钙通道或TREK-1通道有关的疾病的药物组合物含有具有化学式I结构的苯氧基丙醇衍生物或其外消旋体，其药学上可接受的盐，溶剂或水合物作为 活性成分。 抑制T型钙通道或TREK-1通道的方法包括：从生物体制备生物样品的步骤; 以及施用苯氧基丙醇衍生物或外消旋体，其药学上可接受的盐，溶剂合物或水合物的步骤。
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公开(公告)号：KR100980098B1
公开(公告)日：2010-09-03
申请号：KR1020080009377
申请日：2008-01-30
Applicant: 한국과학기술연구원
IPC: A61K48/00 , A61K31/192
CPC classification number: C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53
Abstract: 본 발명은 뉴런 및/또는 성상세포에서의 신경전달물질 방출 조절에 있어서의 음이온 채널, 보다 구체적으로 칼슘 이온에 의하여 활성화되는 음이온 채널 (Ca
2
+ -activated anion cannel, CAAC)의 신규한 용도와 관련된 것으로, CAAC 활성 조절제, CAAC를 포함하는 신경조절물질 방출 조절제, 및 CAAC를 타겟으로 하는 신경조절물질 방출 조절제의 스크리닝 방법을 제공한다.-
Patent Agency Ranking
公开(公告)号：KR1020090084150A
公开(公告)日：2009-08-05
申请号：KR1020080010156
申请日：2008-01-31
Applicant: 한국과학기술연구원
IPC: A61K31/522 , A61P9/10 , A61P13/10 , A61P25/00
CPC classification number: A61K31/522
Abstract: A composition for suppressing an inositol 1,4,5-triphosphate receptor subtype III is provided to prevent and treat diseases which is related to calcium ion release. An agent for suppressing a subtype III of inositol-1,4,5-triphosphate receptor comprises one or more among a group of caffeine, 7-isopropyl theophylline, 7-(beta-hydroxyethyl)theophyline, xanthenes, theophyline, 1,7-dimethyl-3-isobutyl xantene and their pharmaceutically allowable salt as active ingredient. A composition for preventing and treating diseases which is related to calcium ion excessive release comprises one or more among caffeine, 7-isopropyl theophyline, 7-(beta-hydroxyethyl)theopyline, xanthene, theophyline, 1,7-dimethyl-3-isobutyl xanthenes and their pharmaceutically allowable salt as active ingredient. The diseases related to calcium ion excessive release is one of stroke, anxiety, hyper sensitive bladder salt, inflammatory bowel disease, irritable colon syndrome, interstitial colitis, head injury, migraine, chronic, the neuropathy nature or the acute pain, the stress disorder after drug or the alcoholism, the neurological failure, psychosis, somnopathy, phobia, compulsion, debit, and the depression, stroma, diabetes, cancer, the male sterilization, hypertension, pulmonary hypertension, cardiac arrhythmia, congestive heart failure, angina, the polycystic kidney disease [autosomal dominant polycystic kidney] and Duchenne muscular dystrophy (DMD).
Abstract translation: 提供抑制肌醇1,4,5-三磷酸受体亚型III的组合物，以预防和治疗与钙离子释放有关的疾病。 用于抑制肌醇-1,4,5-三磷酸受体亚型III的药剂包括一组咖啡因，7-异丙基茶碱，7-（β-羟乙基）茶碱，呫吨酮，茶碱， 二甲基-3-异丁基呫吨及其药学上允许的盐作为活性成分。 用于预防和治疗与钙离子过度释放有关的疾病的组合物包括咖啡因，7-异丙基茶碱，7-（β-羟乙基）麻黄碱，呫吨，茶碱，1,7-二甲基-3-异丁基呫吨的一种或多种 及其药学上可允许的盐作为活性成分。 与钙离子过度释放相关的疾病是中风，焦虑，超敏性膀胱盐，炎性肠病，肠易激综合征，间质性结肠炎，头部损伤，偏头痛，慢性，神经病变或急性疼痛，紧张性疾病 药物或酒精中毒，神经系统衰竭，精神病，睡眠障碍，恐惧症，强迫性，借贷和抑郁症，基质，糖尿病，癌症，男性绝育，高血压，肺动脉高压，心律失常，充血性心力衰竭，心绞痛，多囊肾 疾病[常染色体显性多囊肾]和杜氏肌营养不良症（DMD）。
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公开(公告)号：KR1020090083532A
公开(公告)日：2009-08-04
申请号：KR1020080009377
申请日：2008-01-30
Applicant: 한국과학기술연구원
IPC: A61K48/00 , A61K31/192
CPC classification number: C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53
Abstract: An agent for controlling the release of neurotransmitter of neuron and/or astrocyte and apply on improving recognition and perception. An agent for regulating the release of excitatory neurotransmitter from a neuron or astrocyte via Ca^2+-activated anion channel(CAAC) comprises a regulator of anion channel which is activated by calcium ion. The anion channel is coded by a bestrophin 1 gene. The excitatory neurotransmitter is acetylcholine asparaginic acid, D-serine, glutamate, enkephalin or histamine. The CAAC agent an antisense RNA or shRNA(short hairpin RNA) to anion channel blocker or CAAC coding nucleotide sequence.
Abstract translation: 用于控制神经元和/或星形胶质细胞的神经递质的释放并用于改善识别和感知的药剂。 通过Ca 2+激活的阴离子通道（CAAC）调节兴奋性神经递质从神经元或星形胶质细胞释放的药剂包含由钙离子激活的阴离子通道的调节剂。 阴离子通道由一个bestrophin 1基因编码。 兴奋性神经递质是乙酰胆碱天冬酰胺酸，D-丝氨酸，谷氨酸，脑啡肽或组胺。 CAAC试剂为阴离子通道阻断剂或CAAC编码核苷酸序列的反义RNA或shRNA（短发夹RNA）。
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公开(公告)号：KR1020180024484A
公开(公告)日：2018-03-08
申请号：KR1020160110775
申请日：2016-08-30
Applicant: 한국과학기술연구원
IPC: C12N5/00 , C12N5/0793 , C12N5/079 , C12M1/00 , C12M1/42
CPC classification number: C12N5/0068 , C12M23/26 , C12M35/00 , C12N5/0619 , C12N5/0622 , C12N2533/54
Abstract: 본명세서는세포배양물질을정렬하기위한장치및 방법에관한것이다. 구체적으로본 명세서는 (1) 탄성기판을압축하는단계; (2) 압축된탄성기판에세포배양용물질을로딩하는단계; 및 (3) 탄성기판을원상회복시키는단계를포함하는세포배양용물질을단일한방향으로정렬하는방법을제공한다. 또한, 본명세서는세포배양용물질이로딩되는탄성기판; 및상기탄성기판의폭을압축시키는압축모듈을포함하는세포배양용물질의정렬장치를제공한다.
Abstract translation: 用于排列细胞培养材料的设备和方法 具体而言，本说明书公开了一种制造半导体器件的方法，包括以下步骤：（1）压缩弹性衬底; （2）将细胞培养材料加载到压缩的弹性基底上; （3）将弹性基底恢复到原始状态。 本发明还涉及其上装载有用于细胞培养的材料的弹性基底; 以及用于压缩弹性基板的宽度的压缩模块。
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公开(公告)号：KR101808221B1
公开(公告)日：2017-12-13
申请号：KR1020160066350
申请日：2016-05-30
Applicant: 한국과학기술연구원
IPC: C12Q1/68
Abstract: 일양상에따른프라이머, 마이크로어레이, 키트, 및이를이용하여개체의인지기능을예측하는방법또는인지기능예측에필요한정보를제공하기위하여개체의 SNP를분석하는방법에의하면, 개체의인지기능의수준을예측또는측정할수 있다. 예측된개체의인지기능수준은치매, 알츠하이머병, 기억력장애등의인지기능장애의진단또는치료를위한정보로이용될수 있고, 개체의인지기능수준별학습가이드를제공하거나, 영재개발및 적성검사등에이용할수 있다.
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