公开(公告)号：CA2778586A1

公开(公告)日：2011-06-09

申请号：CA2778586

申请日：2010-06-01

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D ,  HANSEN TODD M

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D231/56 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12 ,  C07D405/14

Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.

公开(公告)号：CA2744711A1

公开(公告)日：2010-06-10

申请号：CA2744711

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12

Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.

公开(公告)号：CA2515790A1

公开(公告)日：2004-09-10

申请号：CA2515790

申请日：2004-02-26

Applicant: ABBOTT LAB

Inventor： LI GAOQUAN ,  HEXAMER LAURA ,  LIN NAN-HORNG ,  HASVOLD LISA A ,  SOWIN TOM ,  WANG LE ,  SULLIVAN GERARD M ,  SHAM HING ,  XIA PING XIA

IPC: A61P35/00 ,  C07D243/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10 ,  A61K31/551

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AU2004215359A1

公开(公告)日：2004-09-10

申请号：AU2004215359

申请日：2004-02-26

Applicant: ABBOTT LAB

Inventor： HEXAMER LAURA ,  LI GAOQUAN ,  LIN NAN-HORNG ,  SHAM HING ,  SOWIN TOM ,  SULLIVAN GERARD M ,  WANG LE ,  XIA PING XIA ,  HASVOLD LISA A

IPC: A61P35/00 ,  C07D243/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10 ,  A61K31/551

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CA2744711C

公开(公告)日：2017-06-27

申请号：CA2744711

申请日：2009-12-04

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  DOHERTY GEORGE A ,  ELMORE STEVEN W ,  HASVOLD LISA ,  HEXAMER LAURA ,  KUNZER AARON R ,  MANTEI ROBERT A ,  MCCLELLAN WILLIAM J ,  PARK CHANG H ,  PARK CHEOL-MIN ,  PETROS ANDREW M ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WANG GARY T ,  WANG LE ,  WANG XILU ,  WENDT MICHAEL D

IPC: C07D405/12 ,  A61K31/404 ,  A61P35/00 ,  C07D209/32 ,  C07D211/96 ,  C07D213/64 ,  C07D215/20 ,  C07D217/16 ,  C07D235/26 ,  C07D249/04 ,  C07D295/125 ,  C07D295/14 ,  C07D309/14 ,  C07D401/12

Abstract: Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.

公开(公告)号：BRPI1014359A2

公开(公告)日：2016-04-05

申请号：BRPI1014359

申请日：2010-05-26

Applicant: ABBOTT LAB

Inventor： KUNZER AARON R ,  SOUERS ANDREW J ,  WANG GARY T ,  DOHERTY GEORGE ,  SULLIVAN GERARD ,  DING HONG ,  HEXAMER LAURA ,  WANG LE ,  HASVOLD LISA ,  WENDT MICHAEL ,  BRUNCKO MILAN ,  MANTEI ROBERT ,  ELMORE STEVEN ,  HANSEN TODD M ,  SONG XIAOHONG ,  WANG XILU ,  TAO ZHIFU

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

公开(公告)号：SG193849A1

公开(公告)日：2013-10-30

申请号：SG2013066071

申请日：2010-01-15

Applicant: ABBOTT LAB

Inventor： HEXAMER LAURA ,  DING HONG ,  ELMORE STEVEN W ,  KUNZER AARON R ,  SONG XIAOHONG ,  SOUERS ANDREW J ,  SULLIVAN GERARD M ,  TAO ZHI-FU ,  WENDT MICHAEL D

Abstract: APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES5 Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bel-2proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bc1-2 protein. No suitable figure

公开(公告)号：ZA201208832B

公开(公告)日：2013-07-31

申请号：ZA201208832

申请日：2012-11-22

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DOHERTY GEORGE ,  HASVOLD LISA ,  KUNZER AARON R ,  SOUERS ANDREW J ,  TAO ZHI-FU ,  WANG LE ,  WENDT MICHAEL ,  HANSEN TODD M ,  DING HONG ,  ELMORE STEVEN ,  HEXAMER LAURA ,  SONG XIAOHONG ,  SULLIVAN GERARD ,  WANG GARY T ,  WANG XILU ,  MANTEI ROBERT

IPC: A61K20060101 ,  C07D20060101

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：ZA201206837B

公开(公告)日：2013-05-29

申请号：ZA201206837

申请日：2012-09-12

Applicant: ABBOTT LAB

Inventor： DING HONG ,  HEXAMER LAURA ,  PARK CHEOL-MIN ,  SULLIVAN GERARD ,  ELMORE STEVEN ,  KUNZER AARON R ,  SOUERS ANDREW J ,  WENDT MICHAEL

IPC: A61K20060101 ,  A61P20060101 ,  C07C20060101 ,  C07D20060101

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.

公开(公告)号：CA2515790C

公开(公告)日：2012-11-27

申请号：CA2515790

申请日：2004-02-26

Applicant: ABBOTT LAB

Inventor： HASVOLD LISA A ,  HEXAMER LAURA ,  LI GAOQUAN ,  LIN NAN-HORNG ,  SHAM HING ,  SOWIN TOM ,  SULLIVAN GERARD M ,  WANG LE ,  XIA PING XIA

IPC: C07D243/38 ,  A61K31/551 ,  A61P35/00 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.