公开(公告)号：AU614783B2

公开(公告)日：1991-09-12

申请号：AU2440188

申请日：1988-10-27

Applicant: ABBOTT LAB

Inventor： MIMMS LARRY T

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/53 ,  G01N33/571 ,  G01N33/531

Abstract: This invention relates to improved "sandwich" immunoassays for antibodies in body fluids of the type where antigen specific for the antibody to be detected is disposed on a solid support and binds antibody from the body fluid, from which the antibody bound to the solid support is detected by a labeled antigen to the antibody to be detected. The improvement comprises using antigens from heterologous cell sources.

公开(公告)号：CA1341341C

公开(公告)日：2002-02-19

申请号：CA581350

申请日：1988-10-26

Applicant: ABBOTT LAB

Inventor： MIMMS LARRY T

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/531 ,  G01N33/546 ,  G01N33/567

Abstract: This invention relates to improved "sandwich" immunoassays for antibodies in body fluids of the type where antigen specific for the antibody to be detected is disposed on a solid support and binds antibody from the body fluid, from which the antibody bound to the solid support is detected by a labeled antigen to the antibody to be detected. The improvement comprises using antigens from heterologous cell sources.

公开(公告)号：DK0556320T3

公开(公告)日：1999-10-18

申请号：DK92900907

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： DESAI SURESH M ,  DEVARE SUSHIL G ,  MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  MIMMS LARRY T ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K15/00 ,  C12N5/00 ,  C12P21/02 ,  C12Q1/70

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：DK0569537T3

公开(公告)日：1999-04-06

申请号：DK92906219

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C07K15/28 ,  C12N5/00 ,  C12N5/20 ,  C12Q1/70

Abstract: Monoclonal antibodies which specifically bind to putative Hepatitis C Virus (HCV) envelope region. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

公开(公告)号：AT143142T

公开(公告)日：1996-10-15

申请号：AT90104301

申请日：1990-03-07

Applicant: ABBOTT LAB

Inventor： DAWSON GEORGE J ,  MIMMS LARRY T ,  WOOD CHARLES ,  WU PING ,  ROSER MICHELLE A

IPC: G01N33/569 ,  C12N15/49

Abstract: The invention is an improved diagnostic immunoassay for the detection of human sera antibodies specific for human immunodeficiency virus (HIV). The immunoassay utilizes two detection systems which are designed to detect antibodies to two distinct proteins of HIV. One detection system is designed to detect antibodies to surface proteins of HIV, and the other is designed to detect antibodies to core proteins of HIV.

公开(公告)号：DE3854834D1

公开(公告)日：1996-02-08

申请号：DE3854834

申请日：1988-10-20

Applicant: ABBOTT LAB

Inventor： MIMMS LARRY T

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/546

Abstract: This invention relates to improved "sandwich" immunoassays for antibodies in body fluids of the type where antigen specific for the antibody to be detected is disposed on a solid support and binds antibody from the body fluid, from which the antibody bound to the solid support is detected by a labeled antigen to the antibody to be detected. The improvement comprises using antigens from heterologous cell sources.

公开(公告)号：AT132267T

公开(公告)日：1996-01-15

申请号：AT88117476

申请日：1988-10-20

Applicant: ABBOTT LAB

Inventor： MIMMS LARRY T

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/546 ,  G01N33/531 ,  C07K1/36 ,  C12N15/11

Abstract: This invention relates to improved "sandwich" immunoassays for antibodies in body fluids of the type where antigen specific for the antibody to be detected is disposed on a solid support and binds antibody from the body fluid, from which the antibody bound to the solid support is detected by a labeled antigen to the antibody to be detected. The improvement comprises using antigens from heterologous cell sources.

公开(公告)号：AU664179B2

公开(公告)日：1995-11-09

申请号：AU1762992

申请日：1992-03-31

Applicant: ABBOTT LAB

Inventor： TASKAR SUHAS ,  CLEMENS JOHN M ,  MIMMS LARRY T ,  CHAU KURT H ,  VALLARI DAVID S

IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/543 ,  G01N33/569 ,  G01N33/576

公开(公告)号：AU662503B2

公开(公告)日：1995-09-07

申请号：AU9077791

申请日：1991-11-07

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577 ,  C12Q1/70 ,  C12P21/02 ,  C12N5/00

Abstract: Monoclonal antibodies which specifically bind to either Hepatitis C Virus C-100 protein, Hepatitis C Virus 33C protein and Hepatits C Virus CORE protein, and hybridomas which produce these monoclonal antibodies. Also provided are methods for using these monoclonal antibodies and assay kits containing these antibodies.

公开(公告)号：AU6908294A

公开(公告)日：1994-12-12

申请号：AU6908294

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C12N1/21 ,  C12P21/00 ,  C07K7/10 ,  C07K13/00 ,  C07K15/06 ,  C07K17/02 ,  G01N33/569

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.