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公开(公告)号：HU9801910A2
公开(公告)日：1999-01-28
申请号：HU9801910
申请日：1996-06-03
Applicant: BASF AG
Inventor： EMLING FRANZ , HAUPT ANDREAS , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：MX9803953A
公开(公告)日：1998-09-30
申请号：MX9803953
申请日：1998-05-19
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT
IPC: A61K31/00 , A61K38/08 , A61P35/00 , A61K38/00 , A61P35/02 , C07K1/00 , C07K7/06 , C07K07/06 , C07K01/00
Abstract: Se describen péptidos novedosos de la formula R1R2N-CHX-CO-A-B-D-E-(G)s-k en donde R1, R2, A, B, D, E, G, K, X y s tienen los significados establecidos en la descripcion, así como la preparacion de los mismos. Los péptidos novedosos tienen un efecto antineoplásico.
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公开(公告)号：SK165497A3
公开(公告)日：1998-08-05
申请号：SK165497
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Peptides of general formula (I) R1R2N - CHX - CO - A - B - D - E - (F)t - K, wherein R1 is methyl, ethyl or isopropyl, R2 is H, methyl or ethyl, R1-N-R2 together pyrrolidine ring, A residues of Val, Ile, Leu, 2-terc-butylglycyl, 2-ethylglycyl, norleucyl or norvalyl, B residues of N-methyl-valyl, N-methylleucyl, N-methylisoleucyl, N-methylnorvalyl, N-methylnorleucyl, N-methyl-2-terc-butylglycyl, N-methyl-3-terc-butylalanyl or N-methyl- 2-ethylglycyl, D residues pro, 3,4-dehydroprolyl, 4-fluoroprolyl, 4,4-difluoropropyl, asetidine-2-carbonyl, homoprolyl, 3-methylprolyl, 4-methylprolyl, 5-methylprolyl or thiazolidine-4-carbonyl, E 3,4-dehydroprolyl, 4-fluoroprolyl, 3-methylprolyl, 4-methylprolyl, azetidine-2-carbonyl or 4,4-difluoroprolyl, F residues of Val, 2-tec-butylglycyl, Ile, Leu, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, Ala, beta-Ala or amino isobutyroyl, X alkyl, cyclopropyl or cyclopentyl, T is 0 or 1, K alkoxy group, benzyloxy group or group R5-N-R6, or their salts with physiologically suitable acids, pharmaceutical preparation containing them and their use in the medicine, particularly for treatment of oncological diseases and mammals tumours.
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公开(公告)号：NO982711D0
公开(公告)日：1998-06-12
申请号：NO982711
申请日：1998-06-12
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号：ZA969402B
公开(公告)日：1998-05-08
申请号：ZA969402
申请日：1996-11-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MUELLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：NO982100A
公开(公告)日：1998-05-08
申请号：NO982100
申请日：1998-05-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MUELLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
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公开(公告)号：PL323723A1
公开(公告)日：1998-04-14
申请号：PL32372396
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：NO975710A
公开(公告)日：1998-02-02
申请号：NO975710
申请日：1997-12-05
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA
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公开(公告)号：BG61610B2
公开(公告)日：1998-01-30
申请号：BG10096196
申请日：1996-11-06
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: The invention relates to compound Me2Val - Val - MeVal - Pro- Pro - NHBzl.HCl showing antineoplastic activity. It is producedform a compound with the formulaZ - Val - Val - MeVal - Pro - OR1where Z and R1 have the meanings listed in the description.
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公开(公告)号：NZ285092A
公开(公告)日：1998-01-26
申请号：NZ28509295
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKTE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MULLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
IPC: A61K38/08 , A61P35/00 , C07K1/08 , A61K38/00 , C07K5/10 , C07K5/103 , C07K7/06 , C07K14/52 , C07K5/02
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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