公开(公告)号：NO780388A

公开(公告)日：1978-08-08

申请号：NO780388

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  OHNSORGE ULRICH ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS DIETER

IPC: A61K31/428 ,  C07D275/04 ,  C07D

CPC classification number: C07D275/04

公开(公告)号：DK164699C

公开(公告)日：1992-12-21

申请号：DK416082

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  PHILIPSBORN GERDA VON ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C217/36 ,  C07C323/25 ,  C07D207/08 ,  C07D211/14 ,  C07D295/088

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：DK161456C

公开(公告)日：1991-12-16

申请号：DK101781

申请日：1981-03-06

Applicant: BASF AG

Inventor： STEINER GERD ,  HOFMANN HANS PETER ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  LENKE DIETER

IPC: C07D295/14 ,  A61K31/275 ,  A61K31/395 ,  A61K31/50 ,  A61K31/55 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155

Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.

公开(公告)号：DK158979C

公开(公告)日：1991-01-07

申请号：DK566684

申请日：1984-11-29

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：CA1248521A

公开(公告)日：1989-01-10

申请号：CA496920

申请日：1985-12-05

Applicant: FRANKE RENATE ,  BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/135 ,  A61K31/13 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  C07C67/00 ,  C07C213/00 ,  C07C215/38 ,  C07C217/08 ,  C07D295/08 ,  C07D295/084 ,  C07C91/23 ,  C07C93/08

Abstract: By reacting a suitable oxirane with a suitable amine, 10,11-dihydro-5H-dibenzo¢a,d!cycloheptadiene derivatives of general formula (I): (I) where R1 is hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-hydroxyalkyl or C1-C4-alkoxy-C1-C4-alkyl and R2 is hydrogen, or R1 and R2, together with the nitrogen atom which connects them to one another, form a morpholine ring or a piperidine ring which may be substituted in the 4position by hydroxyl and/or by unsubstituted or halogensubstituted phenyl, are produced. These substances, and their salts with physiologically tolerated acids, are useful for the treatment of disorders such as in arrhythmias therapy.

公开(公告)号：FI77224B

公开(公告)日：1988-10-31

申请号：FI823217

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C93/06 ,  C07C93/14 ,  C07C97/10 ,  C07C149/24 ,  C07D207/06 ,  C07D207/12 ,  C07D211/14 ,  C07D211/40

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：NO158675B

公开(公告)日：1988-07-11

申请号：NO821083

申请日：1982-03-31

Applicant: BASF AG

Inventor： STEINER GERD ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/00 ,  A61K31/55 ,  A61P1/04 ,  C07D223/20 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07F9/59

公开(公告)号：FI75155C

公开(公告)日：1988-05-09

申请号：FI810643

申请日：1981-03-02

Applicant: BASF AG

Inventor： STEINER GERD ,  HOFMANN HANS PETER ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  LENKE DIETER

IPC: C07D295/14 ,  A61K31/275 ,  A61K31/395 ,  A61K31/50 ,  A61K31/55 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155

公开(公告)号：FI74962B

公开(公告)日：1987-12-31

申请号：FI780842

申请日：1978-03-17

Applicant: BASF AG

Inventor： VON PHILIPSBORN GERDA ,  BOELL WALTER ,  LENKE DIETER

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：DK150602C

公开(公告)日：1987-12-07

申请号：DK175179

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  THEOBALD HANS ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08

Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.