公开(公告)号：CA2322629A1

公开(公告)日：1999-09-10

申请号：CA2322629

申请日：1999-02-26

Applicant: BASF AG

Inventor： KLEINKE ANDREAS ,  KESSLER THOMAS ,  ROSENBERG JORG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JORG

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/192

Abstract: The invention relates to a method for producing solid, spherical forms containing at least one pharmaceutical active agent homogeneously dispersed in an auxiliary matrix. According to this method, the constituents are mixed to form a melt which is then shaped. The invention is characterised in that at least one pharmaceutical active agent is processed with at least one thermoplastically processable matrix auxiliary to form a homogeneous melt with a viscosity of less than 5000 mPas and in that this melt is shaped into drops using a rotating perforated roll. These drops are then cooled so that they solidify.

公开(公告)号：DE19809242A1

公开(公告)日：1999-09-09

申请号：DE19809242

申请日：1998-03-05

Applicant: BASF AG

Inventor： KLEINKE ANDREAS ,  KESLER THOMAS ,  ROSENBERG JOERG ,  KRULL HARALD ,  BERNDL GUNTHER ,  MAIER WERNER ,  BREITENBACH JOERG

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/192 ,  A61K9/26 ,  A61K31/215

Abstract: The invention relates to a method for producing solid, spherical forms containing at least one pharmaceutical active agent homogeneously dispersed in an auxiliary matrix. According to this method, the constituents are mixed to form a melt which is then shaped. The invention is characterised in that at least one pharmaceutical active agent is processed with at least one thermoplastically processable matrix auxiliary to form a homogeneous melt with a viscosity of less than 5000 mPas and in that this melt is shaped into drops using a rotating perforated roll. These drops are then cooled so that they solidify.

公开(公告)号：AU699971B2

公开(公告)日：1998-12-17

申请号：AU4434196

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JORG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JORG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：AT171613T

公开(公告)日：1998-10-15

申请号：AT95943202

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  FRICKE HELMUT ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05117 Sec. 371 Date Jun. 18, 1997 Sec. 102(e) Date Jun. 18, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19962 PCT Pub. Date Jul. 4, 1996A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.

公开(公告)号：DE19710213A1

公开(公告)日：1998-09-17

申请号：DE19710213

申请日：1997-03-12

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN DR ,  ROSENBERG JOERG DR ,  BREITENBACH JOERG DR ,  KLEINKE ANDREAS DR ,  MAIER WERNER

IPC: A61J3/10 ,  A61K9/20 ,  A61K47/26 ,  A61K47/30 ,  B30B11/16 ,  A61K31/275 ,  A61K31/165

公开(公告)号：HUT77458A

公开(公告)日：1998-04-28

申请号：HU9800063

申请日：1995-12-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  GRABOWSKI SVEN ,  MAIER WERNER ,  ROSENBERG JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：CZ185197A3

公开(公告)日：1998-03-18

申请号：CZ185197

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG DR ,  MAIER WERNER ,  BREITENBACH JORG DR

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

公开(公告)号：SK77197A3

公开(公告)日：1998-02-04

申请号：SK77197

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JORG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：PL321047A1

公开(公告)日：1997-11-24

申请号：PL32104795

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOEERG ,  MAIER WERNER ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

公开(公告)号：PL320936A1

公开(公告)日：1997-11-10

申请号：PL32093695

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JOERG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04