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    Zpusob prípravy 1-substituovaných 5-nebo 3-hydroxypyrazolu
    41.
    发明专利
    Zpusob prípravy 1-substituovaných 5-nebo 3-hydroxypyrazolu 未知

    公开(公告)号：CZ301828B6

    公开(公告)日：2010-07-07

    申请号：CZ20011713

    申请日：1999-11-06

    Applicant: BASF AG

    Inventor： MAYWALD VOLKER ,  STEINMETZ ADRIAN ,  RACK MICHAEL ,  GOETZ NORBERT ,  GOETZ ROLAND ,  HENKELMANN JOCHEM ,  BECKER HEIKE ,  BAYETO JUAN JOSE AISCAR

    IPC: C07D231/20

    Abstract: Je popsán zpusob prípravy 1-substituovaných 5- a/nebo 3-hydroxypyrazolu vzorcu I a II, který zahrnuje reakci (a) alkylvinyletheru vzorce V, s fosgenem vzorce VIa, "difosgenem" vzorce VIb nebo "trifosgenem" vzorce VIc za vzniku acylchloridu vzorce VII, (b) jeho konverzi na odpovídající 3-alkoxyakryloylchlorid vzorce VIII odstranením chlorovodíku a (c) esterifikaci tohoto produktu alkoholem vzorce IX, za vzniku odpovídajícího alkyl-3-alkoxyakrylatu vzorce III, a reakci tohoto alkyl-3-alkoxyakrylatu vzorce III s hydrazinem vzorce IV, (d) pri pH 6 až 11 za vzniku 5-hydroxypyrazolu vzorce I nebo (e) pri pH 11 až 14 za vzniku 3-hydroxypyrazolu vzorce II. Význam všech substituentu je uveden v popise.

    METHOD FOR PRODUCING 1-SUBSTITUTED 5- OR 3-HYDROXYPYRAZOLES
    43.
    发明专利
    METHOD FOR PRODUCING 1-SUBSTITUTED 5- OR 3-HYDROXYPYRAZOLES 未知

    公开(公告)号：CA2351370C

    公开(公告)日：2008-03-11

    申请号：CA2351370

    申请日：1999-11-06

    Applicant: BASF AG

    Inventor： HENKELMANN JOCHEM ,  GOTZ NORBERT ,  RACK MICHAEL ,  BECKER HEIKE ,  AISCAR BAYETO JUAN JOSE ,  STEINMETZ ADRIAN ,  GOTZ ROLAND ,  MAYWALD VOLKER

    IPC: C07D231/20

    Abstract: The invention relates to a method for producing 1-substituted 5- and/or 3- hydroxypyrazoles of formulas (I) and (II), wherein R1 represents C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or C1 - C4-alkoxy, whereby these groups can be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbony l or a cyclic ring system with 3-14 ring atoms, by reacting a 3-alkoxyacrylic acid alkyl ester of formula (III), wherein R2, R3 independently mean C1-C6-alkyl or C3-C6-cycloalky, with a hydrazine of formula (IV), wherein R1 has the above cited meaning, a) at a pH value of 6- 11 to form 5-hydroxypyrazoles of formula (I), or b) at a pH value of 11-14 to form 3-hydroxypyrazoles of formula (II).

    METHOD FOR PRODUCING 1-SUBSTITUTED 5- AND/OR 3-HYDROXYPYRAZOLES
    45.
    发明专利
    METHOD FOR PRODUCING 1-SUBSTITUTED 5- AND/OR 3-HYDROXYPYRAZOLES 未知

    公开(公告)号：HU224721B1

    公开(公告)日：2006-01-30

    申请号：HU0104504

    申请日：1999-11-06

    Applicant: BASF AG

    Inventor： MAYWALD VOLKER ,  STEINMETZ ADRIAN ,  RACK MICHAEL ,  GOETZ NORBERT ,  GOETZ ROLAND ,  HENKELMANN JOCHEM ,  BECKER HEIKE ,  AISCAR BAYETO JUAN JOSE

    IPC: C07D231/20

    Abstract: The invention relates to a process for preparing 1-substituted 5- and/or 3-hydroxypyrazoles of the formulae I and IIin which R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl or C1-C4-alkoxy, where these groups may be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or by a cyclic ring system having 3-14 ring atoms, which comprises reactingan alkyl 3-alkoxyacrylate of the formula IIIin which R2, R3 independently of one another are C1-C6-alkyl or C3-C6-cycloalkyl with a hydrazine of the formula IVin which R1 is as defined abovea) at a pH of 6-11 to give 5-hydroxypyrazoles of the formula I orb) at a pH of 11-14 to give 3-hydroxypyrazoles of the formula II.

    46.
    发明专利
    未知

    公开(公告)号：DE50005355D1

    公开(公告)日：2004-03-25

    申请号：DE50005355

    申请日：2000-11-27

    Applicant: BASF AG

    Inventor： GOETZ ROLAND ,  GOETZ NORBERT ,  KEIL MICHAEL ,  WOLF BERND ,  STEINMETZ ADRIAN ,  STAMM ARMIN ,  HENKELMANN JOCHEM

    IPC: C07C51/00 ,  C07C51/60

    Abstract: A process for preparing o-chloromethylbenzoyl chlorides of the formula I,in which R to R can be identical or different and are hydrogen, C1-C4-alkyl, halogen or trifluoromethyl, by reacting benzo-fused lactones of the formula II,in which R to R are as defined above, with thionyl chloride, which comprises carrying out the reaction in the presence of catalytic amounts of boric acid, boric anhydride, borate, boronic acid or boronic acid esters and catalytic amounts of a quaternary ammonium salt is described.

    47.
    发明专利
    未知

    公开(公告)号：AT259770T

    公开(公告)日：2004-03-15

    申请号：AT00987303

    申请日：2000-11-27

    Applicant: BASF AG

    Inventor： GOETZ ROLAND ,  GOETZ NORBERT ,  KEIL MICHAEL ,  WOLF BERND ,  STEINMETZ ADRIAN ,  STAMM ARMIN ,  HENKELMANN JOCHEM

    IPC: C07C51/00 ,  C07C51/60

    Abstract: A process for preparing o-chloromethylbenzoyl chlorides of the formula I,in which R to R can be identical or different and are hydrogen, C1-C4-alkyl, halogen or trifluoromethyl, by reacting benzo-fused lactones of the formula II,in which R to R are as defined above, with thionyl chloride, which comprises carrying out the reaction in the presence of catalytic amounts of boric acid, boric anhydride, borate, boronic acid or boronic acid esters and catalytic amounts of a quaternary ammonium salt is described.

    49.
    发明专利
    未知

    公开(公告)号：BR0016216A

    公开(公告)日：2002-09-10

    申请号：BR0016216

    申请日：2000-11-27

    Applicant: BASF AG

    Inventor： GOETZ ROLAND ,  GOETZ NORBERT ,  KEIL MICHAEL ,  WOLF BERND ,  STEINMETZ ADRIAN ,  STAMM ARMIN ,  HENKELMANN JOCHEM

    IPC: C07C51/00 ,  C07C51/60

    Abstract: A process for preparing o-chloromethylbenzoyl chlorides of the formula I,in which R to R can be identical or different and are hydrogen, C1-C4-alkyl, halogen or trifluoromethyl, by reacting benzo-fused lactones of the formula II,in which R to R are as defined above, with thionyl chloride, which comprises carrying out the reaction in the presence of catalytic amounts of boric acid, boric anhydride, borate, boronic acid or boronic acid esters and catalytic amounts of a quaternary ammonium salt is described.

    50.
    发明专利
    未知

    公开(公告)号：BR0016244A

    公开(公告)日：2002-08-27

    申请号：BR0016244

    申请日：2000-11-27

    Applicant: BASF AG

    Inventor： STAMM ARMIN ,  GOETZ ROLAND ,  GOETZ NORBERT ,  HENKELMANN JOCHEM ,  KEIL MICHAEL ,  WOLF BERND ,  STEINMETZ ADRIAN

    IPC: C07C51/58 ,  C07B61/00 ,  C07C51/60 ,  C07C57/76 ,  C07C63/10

    Abstract: The invention relates to a method for producing o-chloromethyl benzoic acid chlorides of formula (I), in which R 1 to R 4 can be the same or different and represent hydrogen C 1 -C 4 alkyl, halogen or trifluoromethyl, by reaction benzo condensed lactones of formula (II), in which R 1 to R 4 have the above-mentioned meaning, with thionyl chloride. The inventive method is characterized in that the reaction is carried out in the presence of catalytic quantities of a Lewis acid and in the presence of catalytic quantities of a phosphine derivative.

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