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    Proceso para la preparación de derivados de pirazol
    44.
    发明专利
    Proceso para la preparación de derivados de pirazol 未知

    公开(公告)号：ES2433427T3

    公开(公告)日：2013-12-11

    申请号：ES10707918

    申请日：2010-03-12

    Applicant: BASF SE ,  BASF AGRO B V ARNHEM NL ,  MERIAL LTD

    Inventor： DOCHNAHL MAXIMILIAN ,  SUKOPP MARTIN ,  KORTE ALEXANDER

    IPC: C07D231/38 ,  A61K31/415

    Abstract: Proceso para la preparación de derivados de pirazol de fórmula (I), en la que W es nitrógeno o CR1 R1, R2, R4 y R5 se elige cada uno de independientemente de entre hidrógeno, halógeno, alquilo C1-C6, haloalquilo C1-C6, alcoxi C1-C6, haloalcoxi C1-C6, R7S(O)n, nitro, ciano y pentafluorotio; R3 es hidrógeno, halógeno, alquilo C1-C6, haloalquilo C1-C6, alcoxi C1-C6, haloalcoxi C1-C6, R7S(O)n, nitro, ciano, pentafluorotio o fenilo, que no están sustituidos o están sustituidos por de 1 a 5 miembros del grupo que consiste en halógeno, alquilo C1-C6, haloalquilo C1-C6, alcoxi C1-C6, haloalcoxi C1-C6, R7S(O)n, nitro, ciano y pentafluorotio, que son iguales o diferentes; R7 es alquilo C1-C6 o haloalquilo C1-C6; y n es 0, 1 o 2; caracterizado porque las hidracinas de fórmula (II) en la que W, R2, R3, R4 y R5 son según se definió para los derivados de pirazol de fórmula (I), se hacen reaccionar con un compuesto de fórmula (III)

    45.
    发明专利
    未知

    公开(公告)号：BRPI0718773A2

    公开(公告)日：2013-12-03

    申请号：BRPI0718773

    申请日：2007-11-05

    Applicant: BASF SE

    Inventor： SUKOPP MARTIN ,  KUHN OLIVER ,  GROENING CARSTEN ,  KEIL MICHAEL ,  LONGLET JON J

    IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

    Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof.

    46.
    发明专利
    未知

    公开(公告)号：BRPI0718758A2

    公开(公告)日：2013-12-03

    申请号：BRPI0718758

    申请日：2007-11-05

    Applicant: BASF SE

    Inventor： SUKOPP MARTIN ,  KUHN OLIVER ,  GROENING CARSTEN ,  KEIL MICHAEL ,  LONGLET JON J

    IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

    Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from secondary and/or tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof, wherein the temperature of the reaction mixture at no time exceeds 39° C.

    Proceso para la sulfinilación de un derivado de pirazol
    47.
    发明专利
    Proceso para la sulfinilación de un derivado de pirazol 未知

    公开(公告)号：ES2422297T3

    公开(公告)日：2013-09-10

    申请号：ES07822223

    申请日：2007-11-05

    Applicant: BASF SE ,  BASF AGRO B V ARNHEM NL ZUERICH BRANCH

    Inventor： SUKOPP MARTIN ,  KUHN OLIVER ,  GROENING CARSTEN ,  KEIL MICHAEL ,  LONGLET JON J

    IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

    Abstract: Proceso para la sulfinilación de un derivado de pirazol, caracterizado porque el 5-amino-1-[2,6-dicloro-4-(trifluorometil) fenil]-1H-pirazol-3-carbonitrilo (II) se hace reaccionar con un agente de sulfinilación S en presencia deal menos un complejo de amina-ácido, en donde la amina o las aminas se seleccionan de aminas secundarias y/oterciarias y el o los ácidos se seleccionan de ácido clorhídrico, ácido fluorhídrico, ácido bromhídrico, ácidoyodhídrico, ácido p-toluenosulfónico, ácido bencenosulfónico, ácido 4-etilbencenosulfónico, ácido 4-clorobencenosulfónico, ácido xilenosulfónico, ácido 2,3-dimetilbencenosulfónico, ácido 2,4-dimetilbencenosulfónico,ácido 2,5-dimetilbencenosulfónico, ácido 2,6-dimetilbencenosulfónico, ácido 1-naftalenosulfónico, ácido 2-naftalenosulfónico, mezclas de dos o más de los isómeros del ácido dimetilbencenosulfónico, ácidomesitilenosulfónico, ácido metanosulfónico, ácido canforsulfónico, y ácido trifluorometilsulfónico, y con la adición deun agente de halogenación, en donde S es [CF3S(O)]2O; o CF3S(O)X en donde X significa flúor, cloro, bromo, yodo, un grupo hidroxi, o una sal de metal alcalino o alcalinotérreo del grupo hidroxi; omezclas de estos, en donde la temperatura de la mezcla de reacción en ningún momento exceda 39°C.

    Process for the sulfinylation of a pyrazole derivative
    48.
    发明专利
    Process for the sulfinylation of a pyrazole derivative 未知

    公开(公告)号：AU2007316718B2

    公开(公告)日：2013-03-28

    申请号：AU2007316718

    申请日：2007-11-05

    Applicant: BASF SE

    Inventor： SUKOPP MARTIN ,  GRONING CARSTEN ,  LONGLET JON J ,  KUHN OLIVER ,  KEIL MICHAEL

    IPC: C07D231/44 ,  A01N43/00 ,  A01N43/56 ,  A61K31/415 ,  A61P33/00

    Abstract: The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3- carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.

    Process for preparing difluoromethylpyrazolyl carboxylates
    50.
    发明专利
    Process for preparing difluoromethylpyrazolyl carboxylates 未知

    公开(公告)号：AU2007316081B2

    公开(公告)日：2012-04-26

    申请号：AU2007316081

    申请日：2007-11-02

    Applicant: BASF SE

    Inventor： ZIERKE THOMAS ,  RACK MICHAEL ,  GROTE THOMAS ,  LOHR SANDRA ,  DIETZ JOCHEN ,  RHEINHEIMER JOACHIM ,  SMIDT SEBASTIAN PEER ,  SUKOPP MARTIN ,  LOHMANN JAN KLAAS ,  KEIL MICHAEL

    IPC: C07D237/04 ,  C07F7/04

    Abstract: The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-yl carboxylates of the formula (I) in which R is C-C-alkyl, C-C-cycloalkyl, C-C-alkoxy-C-C-alkyl, etc.; and R is hydrogen, C-C-alkyl, benzyl or phenyl, wherein a) a compound of the general formula (II) in which X is fluorine, chlorine, or bromine, R has one of the definitions given above, and R is C-C-alkyl, C-C-cycloalkyl, C-C-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R SiClin which n is 1, 2 or 3 and the substituents R are each independently selected from C-C-alkyl and phenyl, and with a metal which is selected from the metals of groups 1, 2, 3, 4 and 12 of the periodic table and has a redox potential of less than -0.7 V, based on a standard hydrogen electrode (at 25°C and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula (III) in which R has one of the definitions given above.

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