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公开(公告)号:BRPI0618080A2
公开(公告)日:2012-02-22
申请号:BRPI0618080
申请日:2006-10-23
Applicant: BASF SE
Inventor: ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMANN THERON
Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
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公开(公告)号:ZA200802925B
公开(公告)日:2009-06-24
申请号:ZA200802925
申请日:2008-04-03
Applicant: BASF SE
Inventor: EDZARD SCHOLTEN , MARKUS POMPEJUS , STEPHAN FREYER , MARKUS LOHSCHEIDT , ZELDER OSKAR , MATTHIAS BOY
IPC: A23L7/104 , A23L35/00 , C12P20090101
Abstract: The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism strain which produces the desired metabolites is grown using a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight based on the total weight of the liquid medium, and the volatile constituents of the fermentation liquor are subsequently largely removed, the sugar-containing liquid medium being prepared by: a1) milling selected starch feedstock from cereal grains; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where, for liquefaction purposes, at least a portion of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid. Furthermore, the invention relates to a solid formulation, of a nonvolatile microbial metabolite, obtainable by the method according to the invention; and to the use of such a solid formulation as additive or supplement for human or animal nutrition or for the treatment of textiles, leather, cellulose, paper or surfaces.
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公开(公告)号:MX2008006669A
公开(公告)日:2008-06-02
申请号:MX2008006669
申请日:2008-05-23
Applicant: BASF SE
Inventor: POMPEJUS MARKUS , FREYER STEPHAN , LOHSCHEIDT MARKUS , ZELDER OSKAR , BOY MATTHIAS
Abstract: Preparation of at least one organic compound (I) with at least 3 C atoms or at least two C and at least one N by fermentation. Preparation of at least one organic compound (I) with at least 3 C atoms or at least two C and at least one N by fermentation comprises: (a) millling a starch source (S) to form a milled product (MP) that contains at least part of the non-starch-containing solid components (X) of (S); (b) suspending (MP) in an aqueous liquid and hydrolysis of the starch components by enzymatic liquefaction and optionally subsequent saccharification, to form a first liquid medium (1), containing mono- or oligo-saccharides; and (c) adding (1), together with metabolizable mono-, di- and/or oligo-saccharides (Y), or compositions containing at least 50wt.% (Y) essentially free of water-insoluble solids, to a fermentation medium that contains microorganisms (MO) which can overproduce (I), under fermentation conditions.
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公开(公告)号:AU2013349330B2
公开(公告)日:2019-08-01
申请号:AU2013349330
申请日:2013-11-13
Applicant: BASF SE
Inventor: ZELDER OSKAR , HOFF BIRGIT , SCHRODER HARTWIG , MOLT ANDREA , HARTMANN HOLGER , DITRICH KLAUS , BREUER MICHAEL , REINGRUBER RUDIGER , WEBER JAKOB
IPC: C12N15/11 , A01N37/00 , C07D307/77 , C12N15/63 , C12N15/67
Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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公开(公告)号:ES2708199T3
公开(公告)日:2019-04-09
申请号:ES13734062
申请日:2013-07-03
Applicant: WINTERSHALL HOLDING GMBH , BASF SE
Inventor: BROCKMANN BEATA , HEROLD ANDREA , ZELDER OSKAR , HAEFNER STEFAN , FLECK CHRISTIAN , SCHRÖDER HARTWIG , GRANSTRÖM MARI , SCHMIDT JULIA
Abstract: Un microorganismo genéticamente modificado capaz de producir un polímero que consiste en una cadena principal lineal de unidades ß-D-(1-3)-glucopiranosilo que tienen una sola unidad ß-D-glucopiranosilo (1-6) unida a una unidad ß-D-glucopiranosilo de la cadena principal lineal con un grado de ramificación promedio de alrededor de 0,3, caracterizado porque dicho microorganismo genéticamente modificado sobreexpresa (i) un polinucleótido que codifica un polipéptido que tiene actividad 1,3-ß-D-glucano sintasa, y/o (ii) un polipéptido que tiene actividad 1,3-ß-Dglucano sintasa, en comparación con un microorganismo control no modificado correspondiente de la misma cepa, en el que dicho polímero se selecciona del grupo que consiste en esquizofilano y escleroglucano y en el que dicho microorganismo es Schizophyllum commune.
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公开(公告)号:ES2702930T3
公开(公告)日:2019-03-06
申请号:ES15738594
申请日:2015-02-06
Applicant: BASF SE
Inventor: KRAWCZYK JOANNA MARTYNA , HAEFNER STEFAN , SCHRÖDER HARTWIG , DANTAS COSTA ESTHER , ZELDER OSKAR , VON ABENDROTH GREGORY , WITTMANN CHRISTOPH , STELLMACHER RENÉ , BECKER JUDITH
Abstract: Un microorganismo modificado de la familia Pasteurellaceae en el cual el gen wcaJ se ha delecionado o en el cual se ha introducido al menos una mutación en el gen wcaJ que conduce a la expresión de una enzima truncada codificada por el gen wcaJ en la cual al menos 100 aminoácidos de la enzima de tipo silvestre codificada por el gen wcaJ se delecionan del extremo C terminal, en el que el gen wcaJ comprende un ácido nucleico seleccionado del grupo que consiste en: a) ácidos nucleicos que tienen la secuencia nucleotídica de SEQ ID NO: 3; b) ácidos nucleicos que codifican la secuencia de aminoácidos de SEQ ID NO: 4; c) ácidos nucleicos que son al menos 70 % idénticos al ácido nucleico de a) o b), siendo la identidad la identidad en la longitud total de los ácidos nucleicos de a) o b); d) ácidos nucleicos que codifican una secuencia de aminoácidos que es al menos 70 % idéntica a la secuencia de aminoácidos codificada por el ácido nucleico de a) o b), siendo la identidad la identidad en la longitud total de la secuencia de aminoácidos codificada por los ácidos nucleicos de a) o b), e) ácidos nucleicos capaces de hibridar en condiciones rigurosas con una secuencia complementaria de cualquiera de los ácidos nucleicos de acuerdo con a) o b); y f) ácidos nucleicos que codifican la misma proteína que cualquiera de los ácidos nucleicos de a) o b), pero que difieren de los ácidos nucleicos de a) o b) anteriores debido a la degeneración del código genético.
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公开(公告)号:DK2870239T3
公开(公告)日:2019-02-25
申请号:DK13734062
申请日:2013-07-03
Applicant: WINTERSHALL HOLDING GMBH , BASF SE
Inventor: BROCKMANN BEATA , HEROLD ANDREA , ZELDER OSKAR , HAEFNER STEFAN , SCHRÖDER HARTWIG , SCHMIDT JULIA KRISTIANE , FLECK CHRISTIAN , GRANSTRÖM MARI
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公开(公告)号:CA2938583A1
公开(公告)日:2015-08-13
申请号:CA2938583
申请日:2015-02-06
Applicant: BASF SE
Inventor: KRAWCZYK JOANNA MARTYNA , HAEFNER STEFAN , SCHRODER HARTWIG , DANTAS COSTA ESTHER , ZELDER OSKAR , VON ABENDROTH GREGORY , WITTMANN CHRISTOPH , STELLMACHER RENE , BECKER JUDITH
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.
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公开(公告)号:CA2938231A1
公开(公告)日:2015-08-13
申请号:CA2938231
申请日:2015-02-02
Applicant: BASF SE
Inventor: KRAWCZYK JOANNA MARTYNA , HAEFNER STEFAN , SCHRODER HARTWIG , DANTAS COSTA ESTHER , ZELDER OSKAR , VON ABENDROTH GREGORY , WITTMANN CHRISTOPH , STELLMACHER RENE , BECKER JUDITH , LANGE ANNA , LYONS BENJAMIN J , LYONS THOMAS J , DE CRECY EUDES , HUGHES EWA
Abstract: The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.
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公开(公告)号:AU2013349330A1
公开(公告)日:2015-06-04
申请号:AU2013349330
申请日:2013-11-13
Applicant: BASF SE
Inventor: ZELDER OSKAR , HOFF BIRGIT , SCHRODER HARTWIG , MOLT ANDREA , HARTMANN HOLGER , DITRICH KLAUS , BREUER MICHAEL , REINGRUBER RUDIGER , WEBER JAKOB
IPC: C12N15/11 , A01N37/00 , C07D307/77 , C12N15/63 , C12N15/67
Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
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