公开(公告)号：AT302750T

公开(公告)日：2005-09-15

申请号：AT01955425

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： DESCAMPS-FRANCOIS CAROLE ,  YOUS SAID ,  LESIEUR DANIEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  DA COSTA HERVE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: C07D333/58 ,  A61K31/235 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/20 ,  A61P25/28 ,  A61P35/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/60 ,  C07D209/08 ,  C07D209/20 ,  C07D307/68 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D471/04 ,  C07C209/16 ,  A61K31/165 ,  A61K31/335

Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR' group, or a (C 1 -C 6 )alkyl group substituted by a COOR, CONRR' or OR group, G 1 represents a -X'-(CH 2 ) n -X-(CH 2 ) m -X''- chain wherein X, X', X'', n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G 2 represents an alkylene chain as defined in the description, and A represents a NRCOR', NRCSR', CONRR', CSNRR', NRCONR'R'' or NRCSNR'R'' group.

公开(公告)号：AT301635T

公开(公告)日：2005-08-15

申请号：AT98402963

申请日：1998-11-27

Applicant: SERVIER LAB

Inventor： LEFOULON FRANCOIS ,  DEMUYNCK LUC ,  LESIEUR DANIEL ,  DEPREUX PATRICK ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: A61K31/00 ,  A61K31/10 ,  A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/18 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61P25/20 ,  A61P43/00 ,  C07C233/05 ,  C07C233/17 ,  C07C233/18 ,  C07C233/22 ,  C07C233/31 ,  C07C233/36 ,  C07C233/47 ,  C07C233/58 ,  C07C233/60 ,  C07C255/66 ,  C07C275/24 ,  C07C309/65 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C327/42 ,  C07C335/06 ,  C07D213/56 ,  C07D233/60 ,  C07D307/12 ,  C07D307/52 ,  C07D307/54 ,  C07D333/16 ,  C07D333/20

Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.

公开(公告)号：NZ532221A

公开(公告)日：2005-07-29

申请号：NZ53222104

申请日：2004-04-08

Applicant: SERVIER LAB

Inventor： POISSONNIER-DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  ENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24 ,  A61K31/4045 ,  A61P9/10 ,  A61P25/14 ,  A61P25/18 ,  C07D221/04

Abstract: Described is a compound of formula (I): wherein n is l, 2 or 3, A represents a group -NR-C(=Z)-R', -C(=Z)-N(R)-R', or a group -NR-C(=Z)-N(R')-R", wherein: Z represents a S or O; R and R", which may be identical or different, each represents a H or alkyl group; R' represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl or heteroaryl-alkyl group; X represents N or N-R1 wherein R1 represents a H or alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aroyl, aryl-alkyl, heteroaryl, heteroaroyl or heteroaryl-alkyl group; R2 represents an alkoxy, cycloalkoxy or cycloalkyl-alkoxy group Provided are processes for the preparation of compounds if the formula (I) and descriptions of their use in the preparation of medicaments for treatment of disorders of the melatoninergic system.

公开(公告)号：DE69824046T2

公开(公告)日：2005-06-30

申请号：DE69824046

申请日：1998-12-11

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  JELLIMANN CAROLE ,  ANDRIEUX JEAN ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07D333/74 ,  A61K31/165 ,  A61K31/343 ,  A61K31/381 ,  A61K31/403 ,  A61P9/06 ,  A61P25/20 ,  A61P25/22 ,  A61P43/00 ,  C07C233/05 ,  C07C233/18 ,  C07C233/60 ,  C07C235/34 ,  C07C275/24 ,  C07C275/26 ,  C07D209/60 ,  C07D209/90 ,  C07D307/77 ,  C07D307/92 ,  C07D307/93 ,  C07D333/78

Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0

公开(公告)号：HK1067121A1

公开(公告)日：2005-04-01

申请号：HK04110086

申请日：2004-12-21

Applicant: SERVIER LAB

Inventor： POISSONNIER-DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K20090101 ,  A61K31/472 ,  A61P20090101 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D20090101 ,  C07D217/16 ,  C07D217/24

公开(公告)号：FR2853649A1

公开(公告)日：2004-10-15

申请号：FR0304381

申请日：2003-04-09

Applicant: SERVIER LAB

Inventor： POISSONNIER DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24

公开(公告)号：NO20041313L

公开(公告)日：2004-10-11

申请号：NO20041313

申请日：2004-03-30

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  AUDINOT VALERIE ,  BENNEJEAN CAROLINE ,  WALLEZ VALERIE ,  RENARD PIERRE ,  YOUS SAID ,  DELAGRANGE PHILIPPE ,  POISSONNIER-DURIEUX SOPHIE ,  GASNEREAU ANNE ,  BOUTON JEAN ALBERT

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24 ,  C07D217/22 ,  A61K31/4353

公开(公告)号：EA004762B1

公开(公告)日：2004-08-26

申请号：EA200001157

申请日：2000-12-05

Applicant: SERVIER LAB

Inventor： VIAUD MARIE-CLAUDE ,  GUILLAUMET GERALD ,  DAUBOS PHILIPPE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: A61K31/538 ,  A61K31/5415 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D265/36 ,  C07D279/16 ,  C07D413/06 ,  C07D413/12

Abstract: Изобретениеотноситсяк соединениямформулы (I)где G представляеталкиленовуюцепь, содержащую 1-4-атомауглерода,АпредставляетгруппуX представляетатомкислородаилиатомсерыи Rи Rимеютзначения, указанныев описании. Изобретениетакжеотноситсяк лечебнымсредствам.

公开(公告)号：DE69824046D1

公开(公告)日：2004-06-24

申请号：DE69824046

申请日：1998-12-11

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE-ALLAINMAT MONIQUE ,  JELLIMANN CAROLE ,  ANDRIEUX JEAN ,  BENNEJEAN CAROLINE ,  RENARD PIERRE ,  DELAGRANGE PHILIPPE

IPC: C07D333/74 ,  A61K31/165 ,  A61K31/343 ,  A61K31/381 ,  A61K31/403 ,  A61P9/06 ,  A61P25/20 ,  A61P25/22 ,  A61P43/00 ,  C07C233/05 ,  C07C233/18 ,  C07C233/60 ,  C07C235/34 ,  C07C275/24 ,  C07C275/26 ,  C07D209/60 ,  C07D209/90 ,  C07D307/77 ,  C07D307/92 ,  C07D307/93 ,  C07D333/78

Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0

公开(公告)号：ES2206438T3

公开(公告)日：2004-05-16

申请号：ES02290598

申请日：2002-03-11

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04

Abstract: Compound of formula (I):wherein:R1, R2, R3, R4, R5, R6 and R8, which may be identical or different, each represents hydrogen, alkyl, arylalkyl, hydroxy, alkoxy, arylalkoxy, acyloxy, arylcarbonyloxy, carboxyalkyl or carboxy,R7 represents hydrogen, hydroxy, alkoxy, arylalkoxy, acyloxy or arylcarbonyloxy group,or one of R1 to R8, together with another of R1 to R8 adjacent to it, forms an alkylenedioxy,its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base.