公开(公告)号：GR3032990T3

公开(公告)日：2000-07-31

申请号：GR20000400690

申请日：2000-03-17

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：ES2142890T3

公开(公告)日：2000-05-01

申请号：ES94108957

申请日：1994-06-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：CA2337230A1

公开(公告)日：2000-01-27

申请号：CA2337230

申请日：1999-07-07

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： VENIT JOHN J ,  SZARKA LASZLO J ,  RAMIG KEITH ,  PATEL RAMESH N ,  DONOVAN MARY JO ,  LI WEN-SEN ,  JASS PAUL A ,  HANSON RONALD L ,  GOLDBERG STEVEN

IPC: C12N15/09 ,  C12N1/19 ,  C12N9/06 ,  C12P7/62 ,  C12P13/00 ,  C12P17/04 ,  C12P17/06 ,  C12P41/00 ,  C12R1/01 ,  C12R1/84 ,  C12P7/00 ,  C12P17/00 ,  C12P17/02

Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxyli c acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

公开(公告)号：AU688766B2

公开(公告)日：1998-03-19

申请号：AU6743394

申请日：1994-07-13

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N

IPC: C07D205/08 ,  C07D405/04 ,  C12P17/04 ,  C12P17/16 ,  C12P41/00 ,  C07C229/34

Abstract: Methods for the enzymatic resolution of mixtures of enantiomers, such as beta -lactam compounds, which may be employed as intermediates in the preparation of taxanes bearing a C-13 sidechain containing a heterocyclic or cycloalkyl group, the latter useful in the pharmaceutical field.

公开(公告)号：FI942794A

公开(公告)日：1994-12-16

申请号：FI942794

申请日：1994-06-13

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： HANSON RONALD L ,  PATEL RAMESH N ,  SZARKA LASZLO J

IPC: C12N1/20 ,  C07D305/14 ,  C12N9/14 ,  C12N9/18 ,  C12P17/02 ,  C12Q1/04 ,  C12R1/01 ,  C12N9/00

Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.

公开(公告)号：CA2103932A1

公开(公告)日：1994-05-06

申请号：CA2103932

申请日：1993-08-12

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  BANERJEE AMIT ,  MCNAMEE CLYDE G ,  SZARKA LASZLO J

IPC: A61K31/18 ,  A61P9/00 ,  C07C311/08 ,  C07C311/21 ,  C12P13/02 ,  C12P41/00 ,  C12R1/01 ,  C12R1/645

Abstract: The present invention concerns a process for the stereoselective enzymatic reduction of keto group-containing compounds such as N-(4-(2-chloroacetyl)phenyl)methanesulfon-amido to form the corresponding hydroxyl-group containing compound. The process is selective for the D(+) enantiomer and is catalyzed by enzymes such as oxido-reductase or dehydrogense, or by microorganisms such as Hansenula, Rhodococcus, or Norcardia species.

公开(公告)号：FI934874A0

公开(公告)日：1993-11-04

申请号：FI934874

申请日：1993-11-04

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PATEL RAMESH N ,  BANERJEE AMIT ,  MCNAMEE CLYDE ,  SZARKA LASZLO J

IPC: A61K31/18 ,  A61P9/00 ,  C07C311/08 ,  C07C311/21 ,  C12P13/02 ,  C12P41/00 ,  C12R1/01 ,  C12R1/645 ,  C12P

Abstract: The present invention concerns a process for the stereoselective enzymatic reduction of keto group-containing compounds such as N-(4-(2-chloroacetyl)phenyl)methanesulfonamido to form the corresponding hydroxyl-group containing compound. The process is selective for the D(+) enantiomer and is catalyzed by enzymes such as oxido-reductase or dehydrogense, or by microorganisms such as Hansenula, Rhodococcus, or Norcardia species.

公开(公告)号：BRPI0913197A2

公开(公告)日：2016-01-12

申请号：BRPI0913197

申请日：2009-05-28

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： GOSWAMI ANIMESH ,  ROBL JEFFREY A ,  DEVASTHALE PRATIK ,  PATEL RAMESH N ,  AHMAD SALEEM ,  WASHBURN WILLIAM N ,  GUO ZHIWEI

IPC: C07D495/04 ,  A61K31/522 ,  A61P5/00 ,  A61P25/00

公开(公告)号：CA2508811C

公开(公告)日：2014-11-18

申请号：CA2508811

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM ,  KUCERA DAVID J ,  BANERJEE AMIT

IPC: C07F7/10 ,  C07C67/00 ,  C07D473/12 ,  C07D473/18 ,  C07F7/08 ,  C07F7/18

Abstract: Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

公开(公告)号：SI1644384T1

公开(公告)日：2013-02-28

申请号：SI200332236

申请日：2003-12-10

Applicant: SQUIBB BRISTOL MYERS CO

Inventor： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN ,  KRISHNAMURTY DHILEEPKUMAR ,  ZHOU MAOTANG X ,  VEMISHETTI PURUSHOTHAM ,  BANERJEE AMIT ,  KUCERA DAVID J

IPC: C07D473/00 ,  C07D473/12 ,  C07D473/18 ,  C07F7/00 ,  C07F7/08 ,  C07F7/18