公开(公告)号：CA2635581C

公开(公告)日：2017-02-28

申请号：CA2635581

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA ,  YOUNG CHRISTOPHER R ,  COSTACHE ADRIANA ,  CONNELLY PATRICK ,  KRAWIEC MARIUSZ ,  GONG YUCHUAN ,  ROWE WILLIAM ,  FENG YUSHI ,  TRUDEAU MARTIN

IPC: C07D215/56 ,  A61K31/47 ,  A61P11/00

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound I ), and pharmaceutical compositions thereof.

公开(公告)号：AU2013201426B2

公开(公告)日：2016-06-02

申请号：AU2013201426

申请日：2013-03-12

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA ,  ROWE WILLIAM ,  YOUNG CHRISTOPHER R ,  COSTACHE ADRIANA ,  CONNELLY PATRICK ,  KRAWIEC MARIUSZ ,  GONG YUCHUAN ,  TRUDEAU MARTIN ,  FENG YUSHI

IPC: A61K31/445

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1 ,1-dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

公开(公告)号：AT530546T

公开(公告)日：2011-11-15

申请号：AT08829433

申请日：2008-08-29

Applicant: VERTEX PHARMA

Inventor： ZHANG YUEGANG ,  CONNELLY PATRICK ,  JOHNSTON STEVE

IPC: C07D403/12 ,  A61K31/454 ,  A61P1/16

Abstract: The invention relates to co-crystals and compositions each comprising VX-950 and a co-crystal former selected from the group consisting of 3-methoxy-4-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid. Also within the scope of this invention are methods of making and using the same.

公开(公告)号：BRPI0511900A

公开(公告)日：2008-01-22

申请号：BRPI0511900

申请日：2005-06-08

Applicant: VERTEX PHARMA

Inventor： MURPHY MAURA ,  DINEHART KIRK ,  HURTER PATRICIA ,  CONNELLY PATRICK ,  CUI YONG

IPC: A61K9/00 ,  A01N43/40 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/454 ,  A61K45/06

Abstract: Forms and formulations of VX-950 and uses thereof.

公开(公告)号：AU2005253957A1

公开(公告)日：2005-12-29

申请号：AU2005253957

申请日：2005-06-08

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA ,  CUI YONG ,  DINEHART KIRK ,  CONNELLY PATRICK ,  MURPHY MAURA

IPC: A61K9/00 ,  A01N43/40 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/454 ,  A61K45/06

Abstract: Forms and formulations of VX-950 and uses thereof.