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公开(公告)号：BR112016023422A2
公开(公告)日：2017-08-15
申请号：BR112016023422
申请日：2015-04-14
Applicant: VERTEX PHARMA
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公开(公告)号：PL3424534T3
公开(公告)日：2021-11-22
申请号：PL18173500
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , C07D209/04 , C07D215/00
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公开(公告)号：HRP20211012T1
公开(公告)日：2021-09-17
申请号：HRP20211012
申请日：2021-06-28
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , C07D209/04 , C07D215/00
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公开(公告)号：AU2019250116B2
公开(公告)日：2021-09-16
申请号：AU2019250116
申请日：2019-10-15
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , MCCARTY KATIE LYNN , MEDEK ALES , KNEZIC DRAGUTIN , WAGGENER SARA A
IPC: C07D215/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , A61K45/06 , C07D209/04
Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.
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公开(公告)号：RS62140B1
公开(公告)日：2021-08-31
申请号：RSP20210917
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , C07D209/04 , C07D215/00
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Patent Agency Ranking
公开(公告)号：DK3424534T3
公开(公告)日：2021-07-26
申请号：DK18173500
申请日：2015-04-14
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K45/06 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/404 , A61K31/47 , C07D209/04 , C07D215/00
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公开(公告)号：AU2017371200B2
公开(公告)日：2021-05-06
申请号：AU2017371200
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Compounds of Formula (I) pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
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公开(公告)号：MD3551622T2
公开(公告)日：2021-03-31
申请号：MDE20191168
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Sunt divulgaţi compuşi cu Formula (I):săruri acceptabile farmaceutic ale acestora, derivaţi deuteraţi ai oricărora din cei anteriori, şi metaboliţi ai oricărora din cei anteriori. Sunt de asemenea divulgate compoziţii farmaceutice care îi cuprind pe aceştia, metode de tratare a fibrozei cistice care îi utilizează pe aceştia, şi metode de fabricare ale acestora. Sunt de asemenea divulgate forme ale stării solide a Compusului 1 şi săruri sau solvaţi ai acestuia.
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公开(公告)号：CL2020002757A1
公开(公告)日：2021-02-26
申请号：CL2020002757
申请日：2020-10-23
Applicant: VERTEX PHARMA
Inventor： PHENIX BRIAN DEAN , BAGNOL LAURENT JEAN-CLAUDE , BRODEUR GEOFFREY GLEN , CHANDRAN SACHIN , DOKOU ELENI , FERRIS LORI ANN , KNEZIC DRAGUTIN , MCCARTY KATIE LYNN , MEDEK ALES , WAGGENER SARA A
IPC: A61K31/404 , A61K9/14 , A61K9/16 , A61K9/20 , A61K31/47 , A61K45/06 , C07D209/04 , C07D215/00
Abstract: Este invento caracteriza composiciones que comprenden una pluralidad de agentes terapéuticos en donde la presencia de un agente terapéutico intensifica las propiedades de por lo menos un otro agente terapéutico. En una realización, los agentes terapéuticos son reguladores de conductancia transmembrana de la fibrosis quística (CFTR) tales como un corrector del CFTR o un potenciador del CFTR para el tratamiento de enfermedades mediadas por CFTR, tales como fibrosis quística. Se divulgan también métodos y juegos de implementos.
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公开(公告)号：HRP20201946T1
公开(公告)日：2021-01-22
申请号：HRP20201946
申请日：2020-12-04
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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