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公开(公告)号：EA021706B1
公开(公告)日：2015-08-31
申请号：EA201170330
申请日：2009-08-13
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K47/32
Abstract: Изобретениеотноситсяк областифармацевтики, аименнок таблетке, содержащейтвердуюдисперсию N-[2,4-бис-(1,1-диметилэтил)-5-гидроксифенил]-1,4-дигидро-4-оксохинолин-3-карбоксамидаи способуеевведения. Заявленнаятаблеткахарактеризуетсяхорошейрастворимостьюи высокойстабильностью.
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公开(公告)号：NZ597823A
公开(公告)日：2014-05-30
申请号：NZ59782310
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: 597823 Disclosed herein are pharmaceutical compositions comprising a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1) for use treating or lessening the severity of cystic fibrosis in a patient, and method of manufacturing said compositions. In a preferred embodiment the patient possesses a cystic fibrosis transmembrane receptor (CFTR) with a &Dgr;F508 mutation or G551D mutation on both alleles.
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公开(公告)号：HK1161140A1
公开(公告)日：2012-08-24
申请号：HK12102076
申请日：2012-02-29
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS JACOBUS , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO
IPC: A61K20060101
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：CA2769695A1
公开(公告)日：2011-02-17
申请号：CA2769695
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER R , DINEHART KIRK , OVERHOFF KIRK , GROOTENHUIS PETER D J , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F , VERWIJS MARINUS JACOBUS
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis( 1, 1 -dimethylethyl)-5-hydroxyphenyl]- 1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：MX373230B
公开(公告)日：2025-03-05
申请号：MX2018015847
申请日：2011-02-14
Applicant: VERTEX PHARMA
Inventor： GROSSI ALFREDO , YOUNG CHRISTOPHER , DINEHART KIRK , OVERHOFF KIRK , JACOBUS VERWIJS MARINUS , BOTFIELD MARTYN , HURTER PATRICIA , GROOTENHUIS PETER D J , ROWE WILLIAM
Abstract: La presente invención se refiere a composiciones farmacéuticas que comprenden una dispersión sólida de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida, a métodos de producción de composiciones farmacéuticas de la presente invención y a métodos de administración de composiciones farmacéuticas de la presente invención.
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Patent Agency Ranking
公开(公告)号：SI2464337T2
公开(公告)日：2024-08-30
申请号：SI201031871
申请日：2010-02-18
Applicant: VERTEX PHARMA
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公开(公告)号：FI2464337T4
公开(公告)日：2024-07-18
申请号：FI10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
Inventor： ROWE WILLIAM , HURTER PATRICIA , YOUNG CHRISTOPHER , DINEHART KIRK , VERWIJS MARINUS , OVERHOFF KIRK , GROOTENHUIS PETER , BOTFIELD MARTYN , GROSSI ALFREDO , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
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公开(公告)号：SI3345625T1
公开(公告)日：2021-04-30
申请号：SI200932107
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：DK3345625T3
公开(公告)日：2021-02-01
申请号：DK17204189
申请日：2009-08-13
Applicant: VERTEX PHARMA
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公开(公告)号：ES2718273T3
公开(公告)日：2019-06-28
申请号：ES10708442
申请日：2010-02-18
Applicant: VERTEX PHARMA
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