公开(公告)号：CA2218541A1

公开(公告)日：1996-12-19

申请号：CA2218541

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： WU GUANLI ,  SHEN DEKANG ,  UNGER EVAN C

IPC: A61K47/48 ,  A61K45/00 ,  A61K49/00 ,  A61K49/22 ,  C08F220/44 ,  C08G65/32 ,  C07K17/08 ,  A61B8/13 ,  A61K9/127

Abstract: Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein or a polymer and a gas, in combination with a targeting ligand. The targeting ligand targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

公开(公告)号：AU5375596A

公开(公告)日：1996-10-23

申请号：AU5375596

申请日：1996-03-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/133 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K9/14

公开(公告)号：AU3310395A

公开(公告)日：1996-01-11

申请号：AU3310395

申请日：1995-10-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61B8/13 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  B01J13/02 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60

公开(公告)号：AU1998792A

公开(公告)日：1992-12-30

申请号：AU1998792

申请日：1992-05-22

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： EVAN C. UNGER ,  DEKANG SHEN

IPC: A61K49/00 ,  A61K49/06 ,  A61K49/18 ,  C07C237/12 ,  C07F5/00 ,  C07F13/00 ,  C07F15/02 ,  G01R33/28

公开(公告)号：CA2263568C

公开(公告)日：2008-12-02

申请号：CA2263568

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/10 ,  A61K49/00 ,  A61B5/0275 ,  A61B8/14 ,  A61K31/401 ,  A61K45/08 ,  A61K49/22

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：DE69738964D1

公开(公告)日：2008-10-16

申请号：DE69738964

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61B5/055 ,  A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：DE69738223D1

公开(公告)日：2007-11-29

申请号：DE69738223

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/22

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：DE69835692D1

公开(公告)日：2006-10-05

申请号：DE69835692

申请日：1998-02-25

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER C

IPC: A61K49/04 ,  A61K9/127 ,  A61K9/50 ,  A61K41/00 ,  A61K47/48 ,  A61K49/22

Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.

公开(公告)号：DK0616508T4

公开(公告)日：2005-01-31

申请号：DK92912456

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： WU GUANLI ,  UNGER EVAN C

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61Q19/00 ,  B01J13/02 ,  A61K37/22

Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.

公开(公告)号：DK0788348T3

公开(公告)日：2004-11-29

申请号：DK95927429

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.