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公开(公告)号：KR1020110059827A
公开(公告)日：2011-06-07
申请号：KR1020110044668
申请日：2011-05-12
Applicant: 강릉원주대학교산학협력단
IPC: A61K35/618 , A23L1/30
CPC classification number: A61K35/618 , A23L33/10
Abstract: PURPOSE: A composition containing scallop components is provided to prevent and treat thrombus-associated diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating thrombus-associated diseases contains scallop components as an active ingredient. The scallop extract is isolated using water, acetone, dimethyl ether, low alcohol of 1-4 carbon atoms, or mixture solvent thereof. The scallop is Patinopecten yessoensis, Pecten albicans, Chlamys farreri, Chlamys swifti, Patinopecten(Mizuhopecten) tokyoensis, or Lima sowerbyi. A health food for preventing and treating thrombus-associated diseases contains scallop components as an active ingredient. The health food is manufactured in the form of powder, granule, tablet, capsule, syrup, or beverage.
Abstract translation: 目的：提供含有扇贝组分的组合物，以预防和治疗血栓相关疾病。 构成：用于预防和治疗血栓相关疾病的药物组合物含有扇贝组分作为活性成分。 使用水，丙酮，二甲醚，1-4个碳原子的低级醇或其混合溶剂分离扇贝提取物。 扇贝是Patinopecten yessoensis，Pecten albicans，Chlamys farreri，Chlamys swifti，Patinopecten（Mizuhopecten）tokyoensis或Lima sowerbyi。 用于预防和治疗血栓相关疾病的保健食品含有扇贝组分作为活性成分。 保健食品以粉末，颗粒，片剂，胶囊，糖浆或饮料的形式制造。
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公开(公告)号：KR1020110049576A
公开(公告)日：2011-05-12
申请号：KR1020090106645
申请日：2009-11-05
Applicant: 강릉원주대학교산학협력단
CPC classification number: Y02A50/473
Abstract: PURPOSE: An antibacterial composition containing Undaria pinnatifida (Garney) Suringar extract is provided to ensure antibacterial activity against pathogenic bacteria and to be used in a pharmaceutical composition and health food. CONSTITUTION: An antibacterial contains Undaria pinnatifida (Garney) Suringar extract as an active ingredient. The composition has antibacterial activity against Escherichia coli, Bacillus subtilis, Candida albicans, Streptococcus mutans, or Staphylococcus aureus. The Undaria pinnatifida (Garney) Suringar extract is isolated using water, low alcohol of C1-C4, hexane, chloroform, methylene chloride, ethyl acetate, glycerin, butylene glycol, or mixture solvent.
Abstract translation: 目的：提供含有pin ida（Garney）Suringar提取物的抗菌组合物，以确保对病原菌的抗菌活性，并用于药物组合物和保健食品。 构成：抗菌剂含有pin ida（Garney）Suringar提取物作为活性成分。 该组合物对大肠杆菌，枯草芽孢杆菌，白色念珠菌，变形链球菌或金黄色葡萄球菌具有抗菌活性。 使用水，C1-C4，己烷，氯仿，二氯甲烷，乙酸乙酯，甘油，丁二醇或混合溶剂的低级醇分离Undaria pinnatifida（Garney）Suringar提取物。
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53.发明授权명란젓을 유효성분으로 함유하는 비만 또는 고지혈증 및 동맥경화성 혈관계 질환의 예방 및 치료용 조성물 失效组合物包含用于预防和治疗肥胖症或高脂血症和动脉粥样硬化血管疾病的盐腌阿拉斯加鳕鱼卵
公开(公告)号：KR101027586B1
公开(公告)日：2011-04-06
申请号：KR1020090056203
申请日：2009-06-23
Applicant: 강릉원주대학교산학협력단
Abstract: 본 발명은 명란젓, 명란젓 극성용매 추출물 또는 극성용매 불용성 추출잔사를 유효성분으로 함유하는 비만 또는 고지혈증 및 동맥경화성 혈관계 질환의 예방 및 치료를 위한 조성물에 관한 것으로, 상세하게는 본 발명의 명란젓, 명란젓 극성용매 추출물 또는 극성용매 불용성 추출잔사는 고지혈증을 유발시킨 동물모델에서 간조직 및 분변 중 지질 함량을 감소시키고, 혈청 중의 중성지방, 콜레스테롤, 인지질, 과산화지질 및 Hydroxyl radical 함량을 감소시키며, 혈청 중 SOD 활성을 증진시킴을 확인하였으며, 항비만, 항암, 항산화 효과가 탁월한 것으로 알려져 있는 공역지방산이 다량 함유되어 있음을 확인한 바, 비만 또는 고지혈증 및 동맥경화성 혈관계 질환의 예방 및 치료에 유용한 약학조성물 및 건강기능식품에 이용될 수 있다.
명란젓, 비만, 고지혈증, 콜레스테롤, 항산화-
54.发明授权명태식해를 유효성분으로 함유하는 산화적 스트레스로 인한 간 질환 예방 및 치료용 조성물 失效一种组合物，其包含用于预防和治疗涉及肝脏疾病的氧化应激的盐化的Theragra chalcogramma
公开(公告)号：KR101027576B1
公开(公告)日：2011-04-06
申请号：KR1020090058800
申请日：2009-06-30
Applicant: 강릉원주대학교산학협력단
Abstract: 본 발명은 명태식해를 유효성분으로 함유하는 조성물에 관한 것으로, 상세하게는 본 발명의 명태식해는 Acetaminophen에 의해 간손상이 유발된 실험동물에서 AST, ALT, Aminopyrine demethylase 및 Aniline hydroxylase의 활성을 억제시키고, 지질과산화, cytochrome P-450 및 cytochrome b5의 함량을 감소시키며, 글루타티온 함량을 증가시키고, Glutathione S-transferase, γ-Glutamylcystein synthetase 및 Glutathione reductase의 활성 증진시키는 효과를 확인함으로써, 이를 포함하는 조성물은 산화적 스트레스로 인한 간 질환의 예방 및 치료를 위한 약학 조성물 또는 건강기능식품으로 유용하게 이용될 수 있다.
명태식해, AST, ALT, 항산화 효소, 간 질환-
公开(公告)号：KR1020110022413A
公开(公告)日：2011-03-07
申请号：KR1020090079994
申请日：2009-08-27
Applicant: 강릉원주대학교산학협력단
IPC: A61K35/618 , A23L33/00 , A61K9/19
CPC classification number: A61K35/618 , A23L33/00 , A61K9/19
Abstract: PURPOSE: A composition containing Patinopecten yessoensis ingredient is provided to suppress plasma coagulation and ensure antibacterial effect. CONSTITUTION: A pharmaceutical composition for preventing or treating bacterial infectious diseases or thrombosis-associated diseases contains Patinopecten yessoensis ingredient as an active ingredient. The Patinopecten yessoensis extract is obtained using water including purified water, acetone, dimethyl ether, low alcohol of 1-4 carbon atoms or mixture solvent thereof. The used Patinopecten yessoensis is Patinopecten yessoensis, Pecten albicans, Chlamys farreri, Chlamys swifti, Patinopecten (Mizuhopecten) tokyoensis, or Lima sowerbyi. The composisiton contains 0.01-50 weight% of Patinopecten yessoensis extract. A health food for preventing and treating infectious diseases or thrombosis-associated diseases contains Patinopecten yessoensis extract as an active ingredient. The health food is manufactured in the form of powder, granule, tablet, capsule, syrup, or beverage.
Abstract translation: 目的：提供含有Patinopecten yessoensis成分的组合物，以抑制血浆凝血，确保抗菌作用。 构成：用于预防或治疗细菌感染性疾病或血栓形成相关疾病的药物组合物含有作为活性成分的Patinopecten yessoensis成分。 使用纯净水，丙酮，二甲醚，1-4个碳原子的低级醇或其混合溶剂的水，得到栀子提取物。 使用的Patinopecten yessoensis是Patinopecten yessoensis，Pecten albicans，Chlamys farreri，Chlamys swifti，Patinopecten（Mizuhopecten）tokyoensis或Lima sowerbyi。 该组合含有0.01-50重量％的绦虫提取物。 一种用于预防和治疗感染性疾病或血栓形成相关疾病的保健食品含有作为活性成分的Patinopecten yessoensis提取物。 保健食品以粉末，颗粒，片剂，胶囊，糖浆或饮料的形式制造。
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Patent Agency Ranking56.发明公开성게의 건조분말, 이의 극성용매 가용 추출물 및 극성용매 불용성 잔사를 함유하는 간 해독 및 항산화 활성을 나타내는 조성물 失效包含干粉，极性溶剂提取物和作为活性成分显示肝脏脱氧和抗氧化活性的硫酸钠不溶性残留物的组合物
公开(公告)号：KR1020110001251A
公开(公告)日：2011-01-06
申请号：KR1020090058709
申请日：2009-06-30
Applicant: 강릉원주대학교산학협력단
IPC: A61K35/616 , A23L33/00 , A23L17/20
CPC classification number: A61K35/616 , A23L17/20 , A23L33/00
Abstract: PURPOSE: A composition containing sea urchin extract with detoxification and antioxidation is provided. CONSTITUTION: A pharmaceutical composition for preventing and treating liver diseases contains dried powder of sea urchin, polar solvent soluble extract or polar solvent insoluble residue of the dried powder as an active ingredient. The sea urchin includes Anthocidaris crassispina, Hemicentrotus pulcherrimus, Pseudocentrotus depressus or Strongylocentrotus internmedius. The sea urchin includes eggs, intestine or shell. The polar solvent soluble extract contains an extract obtained using water, low alcohol or mixture solvent thereof.
Abstract translation: 目的：提供含有解毒和抗氧化作用的海胆提取物的组合物。 构成：用于预防和治疗肝脏疾病的药物组合物含有海胆干燥粉末，极性溶剂可溶性提取物或干粉末的极性溶剂不溶残留物作为活性成分。 海胆包括Ant includes ina ina，，，，，，，，，。。。。。。。。。。。。。。。。。。。 海胆包括鸡蛋，肠或壳。 极性溶剂可溶性提取物含有使用水，低级醇或其混合溶剂获得的提取物。
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58.发明公开양미리 분획 건조 분말 또는 그 추출물을 유효성분으로함유하는 통증질환의 예방 및 치료용 조성물 无效包含干燥粉末的砂糖（HYPOPTYCHUS DYBOWSKII）的组合物或其提取物，用于预防和治疗疼痛疾病
公开(公告)号：KR1020100006605A
公开(公告)日：2010-01-21
申请号：KR1020080066789
申请日：2008-07-10
Applicant: 강릉원주대학교산학협력단
Abstract: PURPOSE: A composition containing dried powder of sand lance fraction or its extract is provided to suppress pain using an animal model by inducing acetic acid pain test, heat plate and tail flick test. CONSTITUTION: A pharmaceutical composition for preventing and treating pain contains dried powder or its extract of sand lance fraction as an active ingredient. The extract of sand lance fraction is obtained by heating the sand lance fraction at 60°C-150°C for 12 to 48 hours. The pain is the headache, toothache, backache, burn ache, neuralgia, period pains or arthralgia. The pharmaceutical composition contains 0.1-50 weight% of the dried powder or its extract based on the total weight.
Abstract translation: 目的：提供一种含有喷沙部分或其提取物的干粉的组合物，通过诱导乙酸疼痛试验，加热板和尾巴轻弹试验，通过动物模型抑制疼痛。 构成：用于预防和治疗疼痛的药物组合物含有干燥粉末或其作为活性成分的沙枪部分提取物。 通过在60℃-150℃下加热沙枪级分12至48小时获得沙枪分数的提取物。 疼痛是头痛，牙痛，背痛，疼痛，神经痛，周期痛或关节痛。 该药物组合物含有0.1-50重量％的干燥粉末或其提取物，基于总重量。
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公开(公告)号：KR1020100006599A
公开(公告)日：2010-01-21
申请号：KR1020080066783
申请日：2008-07-10
Applicant: 강릉원주대학교산학협력단
Abstract: PURPOSE: A composition containing dried powder and extract of chub mackerel fraction is provided to reduce total cholesterol and blood triglyceride content. CONSTITUTION: A pharmaceutical composition for preventing and treating hyperlipidemia contains 0.1-50 weight% of dried powder or extract of chub mackerel fraction as an active ingredient. The fraction of the chub mackerel is head, cartilage, shell, muscle, eye, gill, total body of the fish. A method for preparing the dried powder of chub mackerel fraction comprises: a step of washing and removing foreign material and salt from the chub mackerel; and a step of cutting head, cartilage, shell, muscle, eye, gill, and total body. The extract is isolated using water, alcohol and spirit extract solvent.
Abstract translation: 目的：提供含有干粉的组合物和鲭鱼and提取物，以降低总胆固醇和血甘油三酯含量。 构成：用于预防和治疗高脂血症的药物组合物含有0.1-50重量％的干燥粉末或作为活性成分的鲭鱼片提取物。 小鲭鱼的分数是头，软骨，壳，肌肉，眼睛，鳃，鱼的全身。 一种制备鲭鱼m the干燥粉末的方法，包括：从鲭鱼鲭鱼中洗涤除去异物和盐的步骤; 并切割头，软骨，壳，肌肉，眼睛，鳃和全身的一个步骤。 使用水，酒精和精油提取物溶剂分离提取物。
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公开(公告)号：KR1020090105984A
公开(公告)日：2009-10-08
申请号：KR1020080031422
申请日：2008-04-04
Applicant: 강릉원주대학교산학협력단
Abstract: PURPOSE: A method for manufacturing collagen isolated from the skin of bigeye tuna is provided to produce high quality of collagen with high solubility and emulsion stability. CONSTITUTION: A method for manufacturing collagen isolated from the skin of bigeye tuna comprises: a step for washing the skin of the bigeye tuna which is stored at -30 °C to -100 °C; a step for treating the skin with 0.05 ~ 10.0 %(w/v) of alkali solution; a step for washing and neutralizing with distilled water; a step for adding 0.05 ~ 10.0 N of acid to the skin, then stirring and extracting; a step for separating extracted liquid and residue using a centrifuge; and a step for drying to obtain acid soluble collagen (AC); a step for adding 0.5 ~ 5.0 N of acid; a step for adding 0.5 ~ 10% of pepsin and stirring and hydrolyzing for 1 to 60 hours; a step for separating extract liquid and residue using a filter; a step for adding NaCl to adjust the concentration to 1-10 % and neutralizing precipitates; and a step for freeze-drying to obtain a pepsin soluble collagen (PC).
Abstract translation: 目的：提供从大眼金枪鱼皮肤分离的胶原蛋白的制造方法，以生产高质量的胶原蛋白，具有高溶解性和乳液稳定性。 构成：从大眼金枪鱼皮肤分离的胶原蛋白的制造方法，其特征在于，包括：在-30℃-100℃保存的大眼金枪鱼皮肤的洗涤步骤; 用0.05〜10.0％（w / v）碱溶液处理皮肤的步骤; 用蒸馏水洗涤和中和的步骤; 向皮肤中加入0.05〜10.0N的酸，然后搅拌和提取; 使用离心机分离提取液和残渣的步骤; 和干燥以获得酸溶性胶原（AC）的步骤; 添加0.5〜5.0 N酸的步骤; 加入0.5〜10％胃蛋白酶，搅拌水解1〜60小时; 使用过滤器分离提取液和残渣的步骤; 添加NaCl以将浓度调节至1-10％并中和沉淀的步骤; 和冷冻干燥步骤以获得胃蛋白酶可溶性胶原（PC）。
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