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公开(公告)号：KR1020130125488A
公开(公告)日：2013-11-19
申请号：KR1020120049036
申请日：2012-05-09
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/40 , A61K9/06 , A61K31/765 , A61K41/00 , A61K2121/00
Abstract: The present invention relates to photoresponsive microgel. Particularly, the present invention relates to photoresponsive microgel which is a microgel formed by hydrophobic interaction between a photoresponsive surfactant and cyclodextrin polymers. When the microgel is irradiated by light, the size and the crosslinking degree of the microgel are sharply changed by dimerization or de-dimerization of the photoresponsive surfactant.
Abstract translation: 本发明涉及光响应微凝胶。 特别地，本发明涉及光响应性微凝胶，其是通过光响应性表面活性剂与环糊精聚合物之间的疏水相互作用形成的微凝胶。 当光照射微凝胶时，微粒凝胶的尺寸和交联度通过光响应性表面活性剂的二聚化或去二聚作用而急剧变化。
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公开(公告)号：KR1020130098628A
公开(公告)日：2013-09-05
申请号：KR1020120020289
申请日：2012-02-28
Applicant: 강원대학교산학협력단
IPC: C07D311/06 , C07C15/28 , G03F7/004 , C09K3/00
CPC classification number: C07D311/06 , C07C15/28 , C09K3/00 , G03F7/004 , G03F7/0045
Abstract: PURPOSE: A photo-sensitive surfactant is provided to enhance interfacial activity by forming a dimer surfactant such as gemini surfactant through photo-irradiation. CONSTITUTION: A photo-sensitive surfactant contains a photo-reactive material with photopolymerization property, which is conjugated with a surfactant. A method for manufacturing the photo-sensitive surfactant comprises the steps of: dissolving the photo-reactive material with the surfactant in an organic solvent to prepare a mixture solution; and stirring the mixture solution at 50-70°C for 45-50 hours.
Abstract translation: 目的：提供光敏表面活性剂以通过光照射形成二聚体表面活性剂如双子表面活性剂来增强界面活性。 构成：光敏表面活性剂含有具有光聚合性质的光反应性材料，其与表面活性剂结合。 制造感光性表面活性剂的方法包括以下步骤：将光反应性物质与表面活性剂溶解在有机溶剂中以制备混合溶液; 并将混合溶液在50-70℃下搅拌45-50小时。
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公开(公告)号：KR1020130089499A
公开(公告)日：2013-08-12
申请号：KR1020120010920
申请日：2012-02-02
Applicant: 강원대학교산학협력단
IPC: A61K9/16 , A61K8/97 , A61K36/704 , A61Q7/00
CPC classification number: A61K9/5123 , A61K9/5192 , A61K36/14 , A61K36/70 , A61K47/542 , A61K47/6901
Abstract: PURPOSE: Cubic phase nanoparticles for enhancing hair growth are provided to concurrently include a water-soluble component and a fat-soluble component, interact with skin lipid and penetrate stratum corneum, thereby maximizing the hair growth promoting efficacy of herbal extracts. CONSTITUTION: Cubic phase nanoparticles for enhancing hair growth are manufactured by including at least one herbal extract which is selected from a group consisting of biota seed extracts, polygonum multiflorum extracts and espinosilla extracts in the water channels of monoolein cubic phase nano particles. A manufacturing method of the cubic phase nanoparticles for enhancing hair growth comprises a step of manufacturing monoolein cubic phase by adding water phase into molten monoolein; a step of manufacturing cubic phase nanoparticles by homogenizing the monoolein cubic phase after the monoolein cubic phase is added in the water phase in which dispersing agents are dissolved; and a step of stirring the cubic phase nanoparticles and at least one extract selected from a group consisting of biota seed extracts, polygonum multiflorum extracts and espinosilla extracts after mixing the cubic phase nanoparticles and the extracts.
Abstract translation: 目的：提供用于增强毛发生长的立方相纳米颗粒，以同时包含水溶性成分和脂溶性成分，与皮肤脂质相互作用并穿透角质层，从而最大限度地提高促进草药提取物的功效。 构成：用于增强毛发生长的立方相纳米颗粒通过在单油酸酯立方相纳米颗粒的水通道中包含至少一种草本提取物来制造，所述至少一种草药提取物选自由生物种子提取物，多孔提取物和西洋参提取物组成的组。 用于增强头发生长的立方相纳米颗粒的制造方法包括通过将水相加入到熔融单油酸酯中来制备单油酸酯立方相的步骤; 在溶解有分散剂的水相中加入单油酯立方相后，通过均化单油酸酯立方相来制造立方相纳米粒子的步骤; 以及在混合立方相纳米颗粒和提取物之后搅拌立方相纳米颗粒和至少一种选自由生物种子提取物，多孔提取物和多西紫露提取物组成的组的提取物的步骤。
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54.发明公开
公开(公告)号：KR1020130088461A
公开(公告)日：2013-08-08
申请号：KR1020120009703
申请日：2012-01-31
Applicant: 강원대학교산학협력단
CPC classification number: A61K9/1652 , A61K9/1617 , A61K9/1641 , A61K9/1682 , A61K41/0042
Abstract: PURPOSE: A photo-responsive interpenetrating bead is provided to lower crosslink density by photodegradation of a part of photo-crosslinked soluble polymer-coumarin, thereby controlling the release of a target material by photo-irradiation. CONSTITUTION: A photo-responsive interpenetrating bead is composed of alginate and a polymer-coumarin conjugate and has an interpenetrating crosslinked structure. A method for manufacturing the bead comprises the steps of: preparing a polymer-coumarin conjugate; dissolving the polymer-coumarin conjugate with alginate in an aqueous phase to prepare a mixture solution; and irradiating a polyvalent cationic solution by UV ray with a wavelength of 365 nm or greater and dropping the mixture solution to prepare the interpenetrating bead.
Abstract translation: 目的：通过光交联可溶性聚合物 - 香豆素的一部分的光降解来提供光响应互穿珠以降低交联密度，从而通过光照照射来控制靶材料的释放。 构成：光响应互穿珠由藻酸盐和聚合物 - 香豆素缀合物组成，并具有互穿交联结构。 制备珠粒的方法包括以下步骤：制备聚合物 - 香豆素缀合物; 将聚合物 - 香豆素缀合物与藻酸盐溶解在水相中以制备混合物溶液; 并用波长365nm以上的紫外线照射多价阳离子溶液，滴加混合溶液，制备互穿珠粒。
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公开(公告)号：KR1020130066251A
公开(公告)日：2013-06-20
申请号：KR1020110133001
申请日：2011-12-12
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/50 , A61K9/0087 , A61K31/37 , A61K41/0004 , A61K2121/00
Abstract: PURPOSE: A cubic phase containing a surfactant-coumarin conjugate fixed on an aqueous micro-channel is provided to ensure photo-responsive release property and to control release of a hydrophilic target material by UV irradiation. CONSTITUTION: A photo-responsive cubic phase contains a surfactant-coumarin conjugate fixed on an aqueous channel of a monoolein cubic phase. The release of a target material is controlled by irradiating with light. A method for preparing the photo-responsive cubic phase comprises: a step of performing covalent bond of coumarin at a hydrophilic head part of a surfactant and preparing a surfactant-coumarin conjugate; a step of mixing the surfactant-coumarin conjugate with monoolein and melting to prepare a mixture solution; and a step of hydrating the mixture solution and preparing a cubic phase.
Abstract translation: 目的：提供固定在水性微通道上的含有表面活性剂 - 香豆素缀合物的立方相，以确保光敏反应释放性能，并通过紫外线照射来控制亲水性靶材的释放。 构成：光响应立方相包含固定在单油酸酯立方相的水通道上的表面活性剂 - 香豆素缀合物。 通过用光照射来控制目标材料的释放。 制备光响应立方相的方法包括：在表面活性剂的亲水头部进行香豆素的共价键并制备表面活性剂 - 香豆素缀合物的步骤; 将表面活性剂 - 香豆素缀合物与单油酸酯混合并熔融以制备混合溶液的步骤; 和水合该混合溶液并制备立方相的步骤。
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Patent Agency Ranking
公开(公告)号：KR1020120066369A
公开(公告)日：2012-06-22
申请号：KR1020100127677
申请日：2010-12-14
Applicant: 강원대학교산학협력단
CPC classification number: A61K9/16 , A61K47/6949 , C08J3/075 , C08J3/242
Abstract: PURPOSE: A chitosan microgel for inclusion of a target material is provided to control release of the target matetial by responding to pH change. CONSTITUTION: A chitosan microgel contains chitosan which is crosslinked with gluta aldehyde, formaldehyde, or dextrin aldehyde. A method for preparing the chitosan microgel comprises: a step of dissolving the chitosan in an acid solution to prepare a chitosan solution; a step of adding a crosslinking agent of gluta aldehyde, formaldehyde, or dextrin aldehyde into the chitosan solution; a step of spray-drying a mixture solution of chitosan and crosslinking agent to prepare crosslinked chitosan microgel; and a step of loading the target material on the chitosan microgel.
Abstract translation: 目的：提供用于包含靶材料的壳聚糖微凝胶，以通过响应pH变化来控制靶物质的释放。 构成：壳聚糖微凝胶含有与谷氨醛，甲醛或糊精醛交联的壳聚糖。 制备壳聚糖微凝胶的方法包括：将壳聚糖溶解在酸溶液中以制备壳聚糖溶液的步骤; 将谷氨醛，甲醛或糊精醛交联剂加入到壳聚糖溶液中的步骤; 喷雾干燥壳聚糖和交联剂的混合溶液以制备交联的壳聚糖微凝胶的步骤; 以及将目标材料装载在壳聚糖微凝胶上的步骤。
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57.发明授权산성 및 염기성 소수성 화합물과 인클루젼 복합체를 형성하고 있는 사이클로 덱스트린/폴리비닐알콜 수화 겔 및 그 제조방법 有权环糊精/聚（乙烯醇）水合物，其中包括作为用户分子的酸性疏水化合物和碱性疏水化合物及其制备方法
公开(公告)号：KR101055803B1
公开(公告)日：2011-08-09
申请号：KR1020100108693
申请日：2010-11-03
Applicant: 강원대학교산학협력단
IPC: C08F261/04 , C08F251/00 , C08F16/06 , C08J3/075
CPC classification number: C08F261/04 , A61K47/6951 , C08F251/00 , C08J3/075 , C08J3/24
Abstract: PURPOSE: A cyclodextrin/poly(vinyl alcohol) hydrogel is provided to emit relatively many target materials through the ionization of basic(acidic) hydrophobic compounds in an acidic(basic) aqueous solution and to relatively emit relatively a few target materials through the formation of a salt bridge of the acidic hydrophobic compound and the basic hydrophobic compound in a neutral aqueous solution. CONSTITUTION: A method for preparing a cyclodextrin/poly(vinyl alcohol) hydrogel comprises the steps of: (i) adding a crosslinking agent to the mixed liquid of cyclodextrin and poly(vinyl alcohol); (ii) dipping a mixed suspension consisting of a hydrophobic compound having acidic groups and a hydrophobic compound having basic groups to allow the hydrophobic compounds having acidic groups and basic groups to form an inclusion complex in the hydrophobic cavity of the hydrogel; and (iii) mixing the hydrogel with a hydrophilic target material aqueous solution to load the hydrophilic target material on the hydrogel.
Abstract translation: 目的：提供环糊精/聚（乙烯醇）水凝胶，通过在酸性（碱性）水溶液中离子化碱性（酸性）疏水性化合物，通过形成相对较少的靶物质 酸性疏水性化合物的盐桥和碱性疏水化合物在中性水溶液中。 构成：制备环糊精/聚（乙烯醇）水凝胶的方法包括以下步骤：（i）向环糊精和聚（乙烯醇）的混合液中加入交联剂; （ii）浸渍由具有酸性基团的疏水性化合物和具有碱性基团的疏水性化合物组成的混合悬浮液，以使具有酸性基团和碱性基团的疏水性化合物在水凝胶的疏水空腔中形成包合络合物; 和（iii）将水凝胶与亲水性目标材料水溶液混合，以将亲水性目标材料负载在水凝胶上。
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公开(公告)号：KR1020100041616A
公开(公告)日：2010-04-22
申请号：KR1020080100881
申请日：2008-10-14
Applicant: 강원대학교산학협력단
CPC classification number: C08J3/24 , A61K9/1075 , A61K47/30
Abstract: PURPOSE: A polymeric micelle having a salt bridge and a method for preparing the same are provided to quickly and selectively release a target material at acidic and alkaline pH concentrations. CONSTITUTION: A polymeric micelle collecting target materials is formed by a salt bridge between aqueous polymer having acidic group and amphiphilic molecule having an alkaline group. The polymeric micelle having the salt bridge is obtained by mixing the aqueous polymer, amphiphilic molecule and target material on an aqueous phase of which pK value is higher than that of the aqueous polymer and is lower than that of the amphiphilic molecule. The acidic group is carboxyl group, sulfonic group, or phosphate group.
Abstract translation: 目的：提供具有盐桥的聚合物胶束及其制备方法，以在酸性和碱性pH浓度下快速且选择性地释放靶材料。 构成：通过具有酸性基团的水性聚合物和具有碱性基团的两亲性分子之间的盐桥形成聚合物胶束收集目标材料。 具有盐桥的聚合物胶束通过将水性聚合物，两亲性分子和靶材料混合在pK值高于含水聚合物的水相上并且低于两亲性分子的水相而获得。 酸性基团是羧基，磺酸基或磷酸基。
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公开(公告)号：KR1020090017310A
公开(公告)日：2009-02-18
申请号：KR1020070081953
申请日：2007-08-14
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/595 , A61K9/146 , A61K47/6903
Abstract: A poly(N-isopropylacrylamide)-immobilized monoolein cubic phase is provided to release the relatively small amount of the target ingredient at less than phase transition temperature of poly(N-isopropylacrylamide), and release the relatively large amount of the target ingredient at more than phase transition temperature of poly(N-isopropylacrylamide). The poly(N-isopropylacrylamide)-immobilized monoolein cubic phase is manufactured by mixing polyisopropylamide combined with immobilizing material to be immobilized to the aqueous channel within the cubic phase with the target material to be encapsulated into the aqueous channel to prepare the mixed solution; and adding the mixed solution into the monoolein-dissolved solution to form the transparent gel.
Abstract translation: 提供聚（N-异丙基丙烯酰胺） - 单油酸酯立方相以在聚（N-异丙基丙烯酰胺）的低于相变温度下释放相对少量的目标成分，并且在更多的情况下释放相对大量的目标成分 比聚（N-异丙基丙烯酰胺）的相变温度高。 聚（N-异丙基丙烯酰胺） - 单油酸酯立方相是通过将待固定的固定化物质的聚异丙基酰胺与立方相中的水溶液混合，将待包封的目标材料混合到水溶液中制备混合溶液; 并将混合溶液加入溶解于单油溶胶中以形成透明凝胶。
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公开(公告)号：KR102252051B1
公开(公告)日：2021-05-14
申请号：KR1020190124898
申请日：2019-10-08
Applicant: 강원대학교산학협력단
Abstract: 본발명의산화반응성모노올레인큐빅상조성물은양친성성질을가지는히드록시에틸아크릴아미드단위체와페닐비닐황화물단위체의공중합체를포함한다. 상기공중합체는환원환경에서워터채널의이중층에고정되어존재하므로워터채널의확산을억제한다. 반면산화환경이되면상기공중합체가산화되어음의전하가상승하므로상기양친성성질이저하된다. 상기양친성성질의저하는상기공중합체가더 이상워터채널의이중층에고정되지않고워채널내로확산되도록하므로워터채널의확산이향상되어워터채널에탑재된물질이방출되게된다. 따라서본 발명의산화반응성모노올레인큐빅상조성물은산화환경에서특이적으로워터채널에탑재한물질을방출하는효과가있다.
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