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51.发明授权고삼 추출물을 포함하는 성기능 장애 개선용 조성물 失效一种用于处理包含来自A A AN AN AN AN AN TING TING TING TING TING TING TING TING TING TING ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM ROM
公开(公告)号：KR100475647B1
公开(公告)日：2005-03-10
申请号：KR1020020026650
申请日：2002-05-15
Applicant: 한국과학기술연구원
IPC: A61K31/353
Abstract: 본 발명은 화학식 1 및 화학식 2로 표시되는 플라보노이드 화합물 또는 이를 포함하는 고삼 추출물을 유효성분으로 함유하는 성기능 장애 개선용 조성물에 관한 것으로, 상기 조성물은 cGMP 포스포디에스테라제 저해활성을 가짐으로써 발기부전 또는 발기 기능 장애와 같은 성기능 장애를 개선하는데 사용할 수 있다.
화학식 1
(상기식에서, R
1 , R
2 , R
3 , R
4 및 점선은 하기 명세서에 나타낸 바와 같다.)
화학식 2-
公开(公告)号：KR100426612B1
公开(公告)日：2004-04-08
申请号：KR1019990021582
申请日：1999-06-10
Applicant: 한국과학기술연구원
IPC: C12Q1/00
Abstract: PURPOSE: A method for quantifying sugar attached to a solid surface is provided to precisely quantifying the sugar through a gentle reaction by using an enzyme for separating the sugar from a reporter substance without any preprocessing procedure. CONSTITUTION: A method for quantifying sugar attached to a solid surface includes the steps of attaching sugar coupled with reporter molecules such as p-nitrophenyle on a surface of a solid such as a hydrogel selected from Cephalos or Agarose, dissolving glycoside coupling between the sugar and the reporter molecules with an enzyme such as glucosidase, amyloglucosidase, cellulase, fucosidase, mannosidase and galactosidase, and quantifying the dissolved reporter molecules
Abstract translation: 目的：提供一种量化附着于固体表面的糖的方法，以通过使用用于从报道物质分离糖的酶进行温和反应来精确定量糖，而无需任何预处理程序。 构成：定量附着于固体表面的糖的方法包括以下步骤：将糖与报道分子（例如对硝基苯基）偶联在固体（例如选自头孢菌素或琼脂糖的水凝胶）的表面上，将糖与糖之间的糖苷偶联 报道分子与酶如葡糖苷酶，淀粉葡糖苷酶，纤维素酶，岩藻糖苷酶，甘露糖苷酶和半乳糖苷酶，并定量溶解的报道分子
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53.发明授权
公开(公告)号：KR100397792B1
公开(公告)日：2003-09-13
申请号：KR1020010037867
申请日：2001-06-28
Applicant: 한국과학기술연구원
IPC: C07D491/08
CPC classification number: C07D491/04
Abstract: The present invention relates to 4-(phenylamino)-[1,4]dioxano[2,3-g]quinazoline derivatives which inhibit tyrosine kinase of epidermal growth factor receptor(EGFR), and pharmaceutically acceptable salts, hydrates and solvates thereof, and a process for preparing the same. Since 4-(phenylamino)-[1,4]dioxano[2,3-g]quinazoline derivatives of the invention have a high solubility in water and inhibit the activity of EGFR tyrosine kinase and the growth of cancer cells, they can be practically applied in the treatment of overproliferation-associated diseases such as cancer.
Abstract translation: 本发明涉及抑制表皮生长因子受体（EGFR）的酪氨酸激酶的4-（苯基氨基） - [1,4]二氧杂环己烯并[2,3-g]喹唑啉衍生物及其药学上可接受的盐，水合物和溶剂化物，和 一种制备它的方法。 由于本发明的4-（苯基氨基） - [1,4]二氧杂环己二烯并[2,3-g]喹唑啉衍生物在水中具有高溶解度并且抑制EGFR酪氨酸激酶的活性和癌细胞的生长，因此它们可以实际上 用于治疗与过度增殖相关的疾病如癌症。
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公开(公告)号：KR1020020094771A
公开(公告)日：2002-12-18
申请号：KR1020010033212
申请日：2001-06-13
Applicant: 한국과학기술연구원
CPC classification number: A61K8/965 , A61K8/97 , A61Q19/00 , A61Q19/02 , Y10S514/848
Abstract: PURPOSE: Mud increased in porosity by heating mud and removing waste matter to maintain an absorption property when mixed with another skin cosmetic component is provided. A cosmetic composition made by mixing the mud with crude drug has effects on whitening the skin and contracting the pores of the skin. CONSTITUTION: Mud is ground to a size of 100mm or less, heated to 200 to 550deg.C to increase porosity and ground to 300 meshes or less. The cosmetic composition comprises 70 to 95% by weight of porous mud, 5 to 95% by weight of dried powder of crude drug selected from the group consisting of Menthae Herba, Lonicerae Flos, Hoelen, talc, Liriopis Tuber, Astragali Radix, Glycyrrhizae Radix and Armeniacae Semen. The crude drug is dried at 40deg.C or less and then ground to 200 meshes or less.
Abstract translation: 目的：当与另一种皮肤化妆品组分混合时，通过加热泥浆和去除废物以保持吸收性能，泥浆增加孔隙率。 通过将泥浆与生药混合制成的化妆品组合物具有对皮肤美白和收缩皮肤毛孔的作用。 构成：将泥土研磨至100mm以下，加热至200〜550℃，使孔隙率达到300目以下。 化妆品组合物包含70至95重量％的多孔泥浆，5至95重量％的选自以下的生药的干燥粉末：薄荷草，金银花，Hoelen，滑石，Liriopis Tuber，黄芪，甘草 和亚美尼亚精液。 生药在40℃以下干燥，然后研磨至200目以下。
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公开(公告)号：KR1020020090457A
公开(公告)日：2002-12-05
申请号：KR1020010029027
申请日：2001-05-25
Applicant: 한국과학기술연구원
IPC: A61K9/20
CPC classification number: A61K9/205 , A61K9/2013 , A61K36/00
Abstract: PURPOSE: A method for preventing hardening pills by adding a water-soluble high polymer and liquid-keeping agent to Chinese herbal drug powder during the manufacture of the pills is provided which permits easy digestion and enhancement of absorption efficiency of the pills. CONSTITUTION: A water-soluble high polymer and a liquid-keeping agent are added to crude drug powder during manufacture of pills. The water-soluble high polymer is selected from the group consisting of a boiled agar solution, boiled starch, aloe, methyl cellulose and methyl acetate. And the liquid-keeping agent is natural oils containing vegetable oils and animal oils, glycerin or propanediol.
Abstract translation: 目的：提供一种通过在药丸制造过程中向中草药粉中添加水溶性高分子和保液剂来防止硬化丸的方法，其容易消化并提高药丸的吸收效率。 构成：在药丸制造过程中，向生药粉中加入水溶性高分子和保液剂。 水溶性高分子选自沸腾的琼脂溶液，煮沸淀粉，芦荟，甲基纤维素和乙酸甲酯。 液体保持剂是含有植物油和动物油，甘油或丙二醇的天然油。
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Patent Agency Ranking
公开(公告)号：KR100341827B1
公开(公告)日：2002-06-26
申请号：KR1020000004480
申请日：2000-01-29
Applicant: 한국과학기술연구원
IPC: C07K16/00
Abstract: 본발명은 시험관적 면역법을 사용하여 아미노-RNA에 대한 항체 및 이를 제조하는 방법을 제공하여, 일반 RNA로 생체면역법을 이용하여 생성할 수 없는 RNA에 대한 항체를 비교적 안정한 아미노-RNA로서 시험관내 면역법으로 생산할 수 있으며, 또한 얻어진 항체는 자가면역질환의 특정 자가항체와 특이적이고 강하게 결합하여 자기면역질환을 방지할 수 있어 자기면역질환 치료제로 유용하고, 또한 아미노-RNA를 생체내로 투여하여 이에 대한 항체의 생성을 유발할 수 있어 자가면역질환에 대한 백신제로 개발가능하다.
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公开(公告)号：KR1020010001607A
公开(公告)日：2001-01-05
申请号：KR1019990020954
申请日：1999-06-07
Applicant: 한국과학기술연구원
IPC: C07H21/02
Abstract: PURPOSE: Provided is an RNA sequence, which binds to siallyl Lewis (sLe X), of a cancer cell with high specificity and affinity. Also, a method for detecting sLe X using the RNA sequence is provided. The RNA is excellent in binding strength or molecular specificity, therefore, it is useful in detecting the cancer cell and in developing a therapeutic agent thereof. CONSTITUTION: The RNA is selected from the group consisting of SEQ ID NO : 1 - SEQ ID NO : 19 and has the binding specificity and the affinity to sLe X which is a cell surface marker related to an inflammation and a metastasis. The RNA sequence is selected by the steps of preparing the RNA library, fixing the sLe X with CNBr-activating Sepharose 4B and carrying out a systematic evolution of ligand by exponential enrichment (SELEX) method. The detection method of the sLe X comprises the steps of : reacting the sLe X with the RNA sequence selected from SEQ ID NO : 1 - SEQ ID NO : 19; and assaying the RNA bound specifically the sLe X to detect the sLe X.
Abstract translation: 目的：提供具有高特异性和亲和力的癌细胞的与siall Lewis（sLe X）结合的RNA序列。 另外，提供了使用RNA序列检测sLe X的方法。 RNA结合强度或分子特异性优异，因此可用于检测癌细胞和开发其治疗剂。 构成：RNA选自SEQ ID NO：1 - SEQ ID NO：19，并且具有与作为与炎症和转移相关的细胞表面标志物的sLe X的结合特异性和亲和力。 通过制备RNA文库，用CNBr活化的Sepharose 4B固定sLe X并通过指数富集（SELEX）方法进行配体的系统进化来选择RNA序列。 sLe X的检测方法包括以下步骤：使sLe X与选自SEQ ID NO：1 - SEQ ID NO：19的RNA序列反应; 并测定特异性结合sLe X以检测sLe X的RNA。
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58.发明公开
公开(公告)号：KR1020010001605A
公开(公告)日：2001-01-05
申请号：KR1019990020951
申请日：1999-06-07
Applicant: 한국과학기술연구원
IPC: C07H21/02
Abstract: PURPOSE: Provided is an RNA sequence which has a binding specificity to cholesterol or derivatives thereof and which has an activity of a cholesterol esterase. Also, provided is a detection method of a lipophilic substance, especially LDL resulting in arteriosclerosis and a hypertension using the RNA sequence. The sequence is useful in an inhibitor blocking a bioreaction caused by endocrine disruptors and is used as an artificial catalyst without any side effect. CONSTITUTION: The RNA sequence is selected from the group consisting of SEQ ID NO : 1 - SEQ ID NO : 11 and has the activity of a cholesterol esterase. The RNA sequence is prepared by a 131 bp DNA sequence comprising 70 nucleotides of random sequence as shown in Fig. 1, wherein T7 RNA polymerase of 5'-primer promotes an in vitro transcription and the site of a restriction enzyme is useful in identifying that the inserts have been incorporated into the sequence. The detection method of the lipophilic substance comprises the steps of : reacting the lipophilic substance with the RNA sequence selected from SEQ ID NO : 1 - SEQ ID NO : 11; and assaying the RNA bonded specifically with the lipophilic substance to detect the lipophilic substance.
Abstract translation: 目的：提供对胆固醇或其衍生物具有结合特异性并具有胆固醇酯酶活性的RNA序列。 此外，提供亲脂性物质的检测方法，特别是导致动脉硬化的LDL和使用RNA序列的高血压。 该序列可用于阻断由内分泌干扰物引起的生物反应的抑制剂，并用作人造催化剂而没有任何副作用。 构成：RNA序列选自SEQ ID NO：1〜SEQ ID NO：11，具有胆固醇酯酶的活性。 RNA序列由包含70个随机序列核苷酸的131bp DNA序列制备，如图1所示。 1，其中5'-引物的T7RNA聚合酶促进体外转录，并且限制酶的位点可用于鉴定插入片段已经并入序列。 亲脂性物质的检测方法包括以下步骤：使亲脂性物质与选自SEQ ID NO：1〜SEQ ID NO：11的RNA序列反应; 并测定与亲脂性物质特异性结合的RNA以检测亲脂性物质。
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公开(公告)号：KR100234010B1
公开(公告)日：1999-12-15
申请号：KR1019970037236
申请日：1997-08-04
Applicant: 한국과학기술연구원
Abstract: 본 발명은 우산고로쇠로부터 구조식(Ⅰ)로 표시되는 신규한 콰르세틴 - 3 - 0 - (2", 6" - 0 - 디갈로일) - 베타 - D - 갈락토피라노사이드와 함께 공지의 콰르세틴 유도체의 추출방법에 관한 것이다. 본 발명의 신규한 콰르세틴 유도체는 항에이즈 물질로 유용하게 사용될 것으로 기대된다.
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公开(公告)号：KR100215552B1
公开(公告)日：1999-08-16
申请号：KR1019970037395
申请日：1997-08-05
Applicant: 한국과학기술연구원 , 주식회사 녹십자홀딩스
IPC: G01N33/53
Abstract: 본 발명은 검출하고자 하는 시료가 가해지는, 덱스트란으로 처리된 시료 멤브레인:상기 시료 멤브레인과 길이방향으로 겹치도록 연결되며, 검출하고자 하는 마약의 항체와 착색미립자를 결합시킨 마약항체-착색미립자가 일시적으로 고정되어있는 유리섬유 멤브레인;상기 유리섬유 멤브레인과 길이방향으로 겹치도록 연걸되며, 검출하고자 하는 마약에 단백질을 접합시킨 마약-단백질 접합체와 상기 마약의 제2항체가 서로 다른 위치에 영구적으로 고정되어 있는 폴리에스테르 지지 나이트로셀룰로오스 멤브레인; 및·상기 폴리에스테르 지지 나이트르셀룰로오스 멤브레인에 길이방향으로 겹치도록 연결되는 반응액 흡수 멤브례인으로 이루어지는, 측석마약 검출지 및 그것을 제조하는 방법에 관한 발명이다. 본 발명에 의해 보다 짧은 시간에 마약 검출 결과를 얻을 수 있고, 검출 결과 판정이 용이하며, 마약에 대한 민갇성이 향상된 마약검출지가 제공된다.
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