Abstract:
원시 3D 데이터를기초로 3D 오브젝트를구성하는버틱스좌표정보들및 서피스정보들을추출하여 3D 데이터를생성하는데이터추출부, 적어도하나이상의시점들및 상기시점들각각에대응되는데이터그룹들을포함하는다중시야창 데이터를생성하고, 상기데이터그룹들각각은대응되는상기시점에대응되는상기 3D 데이터의버틱스좌표정보들및 서피스정보들을포함하는데이터파싱부, 및상기다중시야창 데이터를랜더링하여상기 3D 오브젝트를재구성한다시점 3D 데이터를생성하는 3D 랜더링부를포함하는데이터처리부, 상기다시점 3D 데이터를이용하여결과영상을출력하는디스플레이부및 사용자입력을통해상기데이터처리부및 상기디스플레이부와상호작용하는인터페이스부를포함하는다중시야창 인터페이스장치.
Abstract:
PURPOSE: Title derivatives useful as radioactive pharmaceuticals are prepared which can extend a residual time in heart, and minimize a radioactive disturbance. CONSTITUTION: 1,12-Dodecane diol is alcohol-substituted by bromic acid to give 12-bromo-dodecane-1-ol, and protected by tetrahydropyrane. Obtained dodecane, 2-ethyl-4,4-dimethyl-2-oxazoline and n-butyl lithium are reacted to give 2(R/S)-(4,4-dimethyl-2-oxazoline-2-yl)-12-tetrahydropyranyl oxy-tetradecane, and esterified with sulfuric acid to give ethyl-2(R/S)-methyl-12-hydroxytetradecaneate. Obtained tetradecaneate is protected to give ethyl-2(R/S)-methyl-14-tetra butyl dimethyl silyloxy-tetradecaneate, followed by reduction with lithium aluminum hydride to give 2(R/S)-methyl-14-t-butyl dimethyl silyloxy-tetradecane-1-ol, tosylated by tosyl chloride, and to give 3(R/S)-methyl-15-t-butyl dimethyl silyloxy-pentadecane-nitrile by substituting with sodium cyanide. Obtained nitride is treated with 1N-hydrochloric acid, hydrolyzed and mesylated to give 16-methane sulfonyl-3-methyl-pentadecanic acid. The pentadecanic acid is brominated, followed by reaction of thiourea and NaOH to give 15-mercapto-3-methyl-pentadecanic acid(formula 1).
Abstract:
본 발명은 신규한 에틸 3-이소시아노 부티레이트 및 의학진단용 영상화제로서 유용한 그의 테크네슘 착화합물에 관한 것이다. 본 발명의 에틸 3-이소시아노 부티레이트는 테크네슘과의 표지 효율이 우수하고 특히 심장/허파 업테이크 비율이 우수하여 배경 장기에 대한 좋은 영상을 얻을 수 있다.