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    이미다졸 염을 포함하는 키랄 비스포스핀을 함유하는 전이금속착물, 이의 중간체 화합물 및 상기 전이금속착물의 제조방법
    51.
    发明公开
    이미다졸 염을 포함하는 키랄 비스포스핀을 함유하는 전이금속착물, 이의 중간체 화합물 및 상기 전이금속착물의 제조방법 失效
    二硫代磷酸酯轴承咪唑盐，其中间体及其制备方法

    公开(公告)号：KR1020050027453A

    公开(公告)日：2005-03-21

    申请号：KR1020030063730

    申请日：2003-09-15

    Applicant: 한국과학기술연구원

    Inventor： 이상기 ,  이재균 ,  장용건 ,  이정근

    IPC: C07F9/6503

    CPC classification number: C07F19/00 ,  C07D233/14 ,  C07F9/5045 ,  C07F9/6506 ,  C07F15/008

    Abstract: Chiral bisphosphine bearing imidazolium salt, their intermediates and a preparation method thereof are provided, which chiral bisphosphine forms chiral metal complex with transition metal ion, has high reactivity during asymmetric hydrogen reaction in ionic liquid, and improved photo-selectivity and conversion rate, and easily isolated and recovered after reaction. The chiral bisphosphine bearing imidazolium salt represented by formula (1) is provided, wherein n is an integer of 1 to 10; R1, R2, R3 and R4 are independently hydrogen, C1-C10 alkyl, C3-C8 cyclic alkyl, aryl or substituted aryl in which the substituent is halogen, C1-C6 alkyl or C1-C6 alkoxy; Z is phenyl or substituted aryl in which the substituent is halogen, C1-C6 alkyl or C1-C6 alkoxy; and X is BF4, PF6, SbF6, OTf or NTf2. The intermediates of the chiral bisphosphine bearing imidazolium salt represented by formula (1) are represented by formula (2), formula (3), formula (4), formula (5) and formula (6), respectively, wherein Y2 is halogen, methane sulfonyl or para-toluenesulfonyl.

    Abstract translation: 提供手性双膦咪唑鎓盐及其制备方法，其中手性双膦与过渡金属离子形成手性金属络合物，在离子液体不对称氢反应中具有高反应性，并提高了光选择性和转化率 反应后分离并回收。 提供由式（1）表示的含有手性双膦的咪唑鎓盐，其中n为1至10的整数; R1，R2，R3和R4独立地是氢，C1-C10烷基，C3-C8环烷基，其中取代基是卤素的芳基或取代的芳基，C1-C6烷基或C1-C6烷氧基; Z是其中取代基是卤素，C 1 -C 6烷基或C 1 -C 6烷氧基的苯基或取代的芳基; X为BF4，PF6，SbF6，OTf或NTf2。 由式（1）表示的含有手性双膦的咪唑鎓盐的中间体分别由式（2），式（3），式（4），式（5）和式（6）表示，其中Y2是卤素， 甲磺酰或对甲苯磺酰。

    (알)-3-히드록시-4-클로로부티르산 에스테르의 제조방법
    53.
    发明公开
    (알)-3-히드록시-4-클로로부티르산 에스테르의 제조방법 失效
    （Al）-3-羟基-4-氯丁酸酯

    公开(公告)号：KR1019970021056A

    公开(公告)日：1997-05-28

    申请号：KR1019950033842

    申请日：1995-10-04

    Applicant: 한국과학기술연구원

    Inventor： 송충의 ,  인인오 ,  이재균

    IPC: C07C69/675

    Abstract: 본 발명은 출발물질로서 다음 구조식(Ⅱ)의 (R)-4-(트리클로로메틸)옥세탄-2-온을 산 촉매 하에 C
    1 -C
    10 지방족 알코올 또는 벤질알코올과 반응시켜 다음 일반식(Ⅲ)의 (R)-3-히드록시-4,4,4-트리클로로부티르산 에스테르를 제조한 다음, 일반식(Ⅲ)의 화합물의 4-위치를 선택적으로 탈염소화(Bis-dechlorination)시키는 것으로 이루어진 다음 일반식(I)의 (R)-3-히드록시-4-클로로부티르산 에스테르의 제조방법에 관한 것이다.

    상기 식에서 R은 C
    1 -C
    18 의 지방족 알킬기 또는 벤질기이다.
    본 발명의 제조방법은 (R)-카르니틴 또는 (R)-3-히드록시-4-아미노부티르산의 제조에 이용되는 핵심 중간체인 (R)-3-히드록시-4-클로로부티르산 에스테르를 매우 높은 수율로 또한 광학적으로 순수한 형태로 얻을 수 있다.

    미토콘드리아 기능 조절에 활성을 지닌 트리아졸 유도체
    58.
    发明公开
    미토콘드리아 기능 조절에 활성을 지닌 트리아졸 유도체 有权
    三唑衍生物作为麻醉功能调节剂

    公开(公告)号：KR1020130096900A

    公开(公告)日：2013-09-02

    申请号：KR1020120018466

    申请日：2012-02-23

    Applicant: 한국과학기술연구원

    Inventor： 민선준 ,  조용서 ,  배애님 ,  이재균 ,  이지연 ,  정선화 ,  박병건

    IPC: C07D403/04 ,  C07D249/06 ,  A61K31/41 ,  A61K31/4025

    Abstract: PURPOSE: A triazole derivative is provided to be used as a restorative of mitochondrial dysfunction with effects of treating Alzheimer's diseases, Parkinson's disease, Huntington's disease, ischemic diseases, diabetes, and schizophrenia. CONSTITUTION: A compound is selected among a triazole derivative of chemical formula 1and a pharmaceutically acceptable salt thereof. A pharmaceutical composition for treating Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic disease, diabetes, and schizophrenia contains the compound as an active ingredient. A method for preparing the triazole compound comprises the step of reacting an azide compound of chemical formula 2 and an ethynyl benzene compound of chemical formula 3 by dipolar cycloaddition.

    Abstract translation: 目的：提供三唑衍生物作为线粒体功能障碍的修复剂，具有治疗阿尔茨海默氏病，帕金森病，亨廷顿病，缺血性疾病，糖尿病和精神分裂症的作用。 构成：化合物选自化学式1的三唑衍生物及其药学上可接受的盐。 用于治疗阿尔茨海默病，帕金森病，亨廷顿病，缺血性疾病，糖尿病和精神分裂症的药物组合物含有该化合物作为活性成分。 制备三唑化合物的方法包括通过偶极环加成使化学式2的叠氮化合物与化学式3的乙炔基苯化合物反应的步骤。

    미토콘드리아 기능 조절제로서의 아릴옥심 유도체
    60.
    发明授权
    미토콘드리아 기능 조절제로서의 아릴옥심 유도체 有权
    ARYLOXIME衍生物作为麻醉功能调节剂

    公开(公告)号：KR101267937B1

    公开(公告)日：2013-05-31

    申请号：KR1020120018465

    申请日：2012-02-23

    Applicant: 한국과학기술연구원

    Inventor： 민선준 ,  배애님 ,  조용서 ,  이재균 ,  김영습 ,  최연희 ,  이지연

    IPC: C07C251/48 ,  A61K31/26 ,  A61P25/00

    Abstract: PURPOSE: Aryloxime derivatives are provided to show excellent activity as a neuroprotective agent acting on mitochondria, therefore, to be useful as a treatment and prevention agent of diseases such as Alzheimer disease, Parkinson's disease, Huntington disease, ischemic disease, diabetes, and schizophrenia. CONSTITUTION: A chemical is selected from aryloxime derivatives represented by Chemical formula 1, and pharmaceutically acceptable salt thereof. In the chemical formula 1; R^1 represents a 4-8 membered azacyclic group or a 7-9 membered azabicylic group, and the azacyclic or azabicyclic group is able to be substituted with 1-3 substituents selected from C1-6 alkyl and benzyl, or be non-substituted; R^2 and R^3 respectively represent a hydrogen group, a halogen group, a C1-C6 alkyl group, a C1-C6 haloalkyl group, or a C1-C6 alkoxy group; and n is an integer of 0, 1, 2 or 3.

    Abstract translation: 目的：提供芳肟衍生物作为作用于线粒体的神经保护剂具有优异的活性，因此可用作诸如阿尔茨海默病，帕金森病，亨廷顿病，缺血性疾病，糖尿病和精神分裂症等疾病的治疗和预防剂。 构成：选自化学式1表示的芳肟衍生物及其药学上可接受的盐。 在化学式1中; R 1表示4-8元氮杂环基或7-9元氮杂双环基，氮杂环或氮杂双环基团可以被1-3个选自C 1-6烷基和苄基的取代基取代，或被取代 ; R 2和R 3分别表示氢基，卤素基，C 1 -C 6烷基，C 1 -C 6卤代烷基或C 1 -C 6烷氧基; n为0,1,2或3的整数。

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