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公开(公告)号：KR1020160088711A
公开(公告)日：2016-07-26
申请号：KR1020150008132
申请日：2015-01-16
Applicant: 한국과학기술연구원
IPC: G02B27/01
CPC classification number: G02B27/0176
Abstract: 표정모니터링또는립 리딩을위한헤드마운트형카메라장치는, 사용자의머리에고정되는머리고정모듈과, 상기머리고정모듈에대해회동가능하게연결되는카메라고정모듈과, 스테레오카메라를포함하고, 상기카메라고정모듈에결합되어상기사용자의얼굴앞쪽에배치되는카메라모듈및 상기머리고정모듈에대한상기카메라고정모듈의위치를선택적으로고정시킬수 있는잠금모듈을포함한다.
Abstract translation: 用于面部表情监测或唇读的头戴式相机装置包括固定到用户头部的热定影模块和可旋转地连接到头部固定模块的相机固定模块，以及包括立体声的相机模块 照相机与相机固定模块组合，并且布置在用户面部的前面，以及锁定模块，其可以选择性地固定用于热定影模块的相机固定模块的位置。 因此，头戴式相机装置可用于严重残疾人士。
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公开(公告)号：KR101492168B1
公开(公告)日：2015-02-11
申请号：KR1020130047644
申请日：2013-04-29
Applicant: 한국과학기술연구원
Abstract: 본 발명은 양친매성 핵산분자, 이를 포함하는 핵산 복합체 및 이의 약물 전달체로서의 용도에 관한 것이다. 본 발명의 약물 전달체는 약물을 표적 세포 및 표적 조직에 선택적으로 전달할 수 있고 세포독성 문제가 없으며 세포투과 후에는 약물의 효과적인 세포질 방출이 가능하여 암 치료제, 세포기반 약물 스크리닝 방법 등에서 크게 응용될 수 있다.
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公开(公告)号：KR1020150006256A
公开(公告)日：2015-01-16
申请号：KR1020130079828
申请日：2013-07-08
Applicant: 한국과학기술연구원
Abstract: 전극체를 이용한 전기 자극 시스템은, 자극 전류를 전도성 매질에 인가하는 전극체와, 입력 펄스를 이용해 상기 자극 전류를 생성하여 상기 전극체에 입력하는 자극 전류 생성 유닛과, 상기 전극체에서 출력되는 전극 전압에서 전극 오프셋 전압을 분류하여 출력하는 샘플 앤 홀드 유닛을 포함하고, 상기 샘플 앤 홀드 유닛은, 상기 입력 펄스가 인가되면 상기 입력 펄스의 인가 시점에서 출력된 전극 전압 값을 샘플링하고, 샘플링된 전극 전압 값을 자극 주기에서의 전극 오프셋 전압 값으로 고정 출력한다.
Abstract translation: 使用电极体的电刺激系统包括：向导电介质施加受激电流的电极体; 刺激电流产生单元，其使用输入脉冲产生刺激电流并将其输入到电极体中; 以及从电极体输出的电极电压分类并输出电极偏移电压的采样保持单元。 采样和保持单元对施加输入脉冲的输入脉冲的施加时间输出的电极电压值进行采样，并将采样的电极电压值固定地输出为刺激周期中的电极偏移电压值。
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公开(公告)号：KR101422669B1
公开(公告)日：2014-07-24
申请号：KR1020130079829
申请日：2013-07-08
Applicant: 한국과학기술연구원
IPC: A61B5/11
Abstract: A gait phase detection system to detect a gait phase including a stance phase and a swing phase includes: a signal detection electrode to detect a neural signal; and a gait phase detection module to detect the gait phase from the neural signal. The gait phase detection module eliminates a portion, including a stimulus-artifact, among the continuously detected neural signals in a predetermined time unit to divide the neural signal into a plurality of segmented neural signals; extracts a feature vector of each segmented neural signal; and substitutes the extracted feature vector to a probability model of the feature vectors of the neural signal of preset stance and swing phases to determine the gait phase of the corresponding segmented neural signal.
Abstract translation: 一种用于检测包括姿势相位和摆动相位的步态相位的步态相位检测系统，包括：检测神经信号的信号检测电极; 以及步态相位检测模块，用于检测来自神经信号的步态相位。 步态相位检测模块以预定的时间单位在连续检测的神经信号中消除包括刺激伪影的部分，以将神经信号划分成多个分段的神经信号; 提取每个分段神经信号的特征向量; 并将所提取的特征向量代入预设姿态和摆动相位的神经信号的特征向量的概率模型，以确定对应的分段神经信号的步态相位。
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Patent Agency Ranking
公开(公告)号：KR101370004B1
公开(公告)日：2014-03-19
申请号：KR1020120142274
申请日：2012-12-07
Applicant: 한국과학기술연구원
CPC classification number: A61F2/04 , A61F2240/00
Abstract: A jig according to the present invention is a jig for molding a nerve conduit, which comprises: a support body connected to the terminal of an injured nerve; and a thin film type sieve electrode body having electrode holes formed in a body and circular electrodes arranged around the electrode holes, wherein the body of the sieve electrode body is buried in the support body that has hollow channels extended to the inside thereof, while the electrode holes are arranged together with the channels. The jig comprises: a plurality of molds that are coupled with the sieve electrode body to envelop the sieve electrode body, and coupled with each other to form a molding space corresponding to the support body; mold caps that are coupled with the molds to close the molding space; arranging pins passing through the electrode holes; and hollow channel tubes that are coupled with the mold caps and extended into the molding space. The channel tubes are brought in contact with the sieve electrode body while the arranging pins are inserted into the channel tubes; and a molten material, which forms the support body through hardening, is injected into the molding space.
Abstract translation: 根据本发明的夹具是用于模制神经导管的夹具，其包括：连接到受伤神经的末端的支撑体; 以及薄膜型筛电极体，其具有形成在主体中的电极孔和设置在电极孔周围的圆形电极，其中，筛电极体的主体埋设在具有延伸到其内部的中空通道的支撑体中， 电极孔与通道一起布置。 夹具包括：多个模具，其与筛电极体结合以包围筛电极体，并且彼此耦合以形成对应于支撑体的模制空间; 模具帽与模具结合以封闭模制空间; 布置穿过电极孔的销; 以及与模具盖连接并延伸到模制空间中的中空通道管。 通道管与筛电极本体接触，同时将排列销插入通道管中; 并且通过硬化形成支撑体的熔融材料被注入到模制空间中。
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公开(公告)号：KR101370003B1
公开(公告)日：2014-03-19
申请号：KR1020120142266
申请日：2012-12-07
Applicant: 한국과학기술연구원
CPC classification number: A61B5/04001 , A61N1/0551
Abstract: A neural tube includes a supporter connected to the end of a damaged nerve, and a sieve electrode body which comprises an electrode hole on a body and a circular electrode wired around the electrode hole. The body of the sieve electrode body is installed inside the supporter, and a hollow channel extended to the inside of the supporter is formed on the supporter. The electrode hole is arranged to be aligned with the channel, which enables a nerve cell grown along the channel from the end of the damaged nerve to contact the circular electrode.
Abstract translation: 神经管包括连接到损伤的神经的末端的支撑体，以及包括主体上的电极孔和围绕电极孔布线的圆形电极的筛电极体。 筛电极体的主体安装在支撑体的内部，并且在支撑体上形成延伸到支撑件内侧的中空通道。 电极孔布置成与通道对准，这使得沿着通道从受损神经末端生长的神经细胞能够接触圆形电极。
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公开(公告)号：KR1020140021395A
公开(公告)日：2014-02-20
申请号：KR1020120087882
申请日：2012-08-10
Applicant: 한국과학기술연구원
IPC: C07K14/08 , C12N15/113 , A61K48/00 , A61P35/00
CPC classification number: C07K14/001 , A61K47/62 , C07K14/08 , C12N15/111 , C12N2310/14 , C12N2320/32
Abstract: The present invention relates to a recombinant protein for siRNA delivery and a composition comprising the same. The recombinant protein for siRNA delivery according to the present invention can obtain safety of siRNA from external attack such as various lyases, have selective coherence to cancer cells by targeted peptide which targets various cancer cells, and silence target genes by effectively delivering siRNA to cells and biotissues by releasing siRNA to cytoplasm after cell penetration so that the recombinant protein for siRNA delivery can be effectively used as a siRNA medicine, a cell based drug screening composition, and a siRNA carrier for research.
Abstract translation: 本发明涉及用于siRNA递送的重组蛋白质和包含其的组合物。 根据本发明的用于siRNA递送的重组蛋白质可以从诸如各种裂解酶的外部攻击获得siRNA的安全性，通过靶向各种癌细胞的靶向肽对癌细胞具有选择性一致性，并且通过有效地将siRNA递送至细胞来沉默靶基因，以及 通过在细胞穿透之后将siRNA释放到细胞质，使得用于siRNA递送的重组蛋白可以有效地用作siRNA药物，基于细胞的药物筛选组合物和用于研究的siRNA载体来生物制剂。
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公开(公告)号：KR1020130134810A
公开(公告)日：2013-12-10
申请号：KR1020120058600
申请日：2012-05-31
Applicant: 한국과학기술연구원
CPC classification number: A61K9/5146 , A61K9/0004 , A61K9/0009 , A61K9/0019 , A61K9/5153 , A61K41/0028 , A61K47/6925 , A61K49/0032 , A61K49/0054 , A61K49/0093 , A61K49/222 , A61K49/225
Abstract: The present invention relates to tumor-targeting gas-generating nanoparticles, a method for preparing the same, and tumor-targeting drug delivery nanoparticles using the same and, more specifically, to tumor-targeting gas-generating nanoparticles including a carbonate polymer core and an amphiphilic outer cover, a method for preparing the same, and tumor-targeting drug delivery nanoparticles using the same. The tumor-targeting gas-generating nanoparticles according to the present invention can be usefully used as an ultrasonic imaging agent since the nanoparticles generate a strong ultrasonic signal after being aggregated and accumulated in the tumor tissue and shows improved performance in tumor specific drug delivery since the nanoparticle has improved penetration and bodily fluid effects and improved cell transmission ability, and the like. [Reference numerals] (AA) Carbonate polymer core;(BB) Amphiphilic outer cover;(CC) Diffuse H_2O;(DD) Hydrolysis;(EE) Generate CO_2;(FF) Ultrasonic signal generation;(GG) Tumor accumulation;(HH) Bonding
Abstract translation: 本发明涉及肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的肿瘤靶向药物递送纳米粒子，更具体地，涉及包含碳酸酯聚合物核心和 两亲性外覆盖物，其制备方法和使用其的肿瘤靶向药物递送纳米粒子。 根据本发明的肿瘤靶向产生气体的纳米颗粒可以有效地用作超声显像剂，因为纳米颗粒在聚集并积累在肿瘤组织中后产生强烈的超声信号，并且在肿瘤特异性药物递送中表现出改进的性能，因为 纳米颗粒具有改善的渗透和体液效应和改善的细胞传递能力等。 （AA）碳酸酯聚合物芯;（BB）两亲性外盖;（CC）扩散H_2O;（DD）水解;（EE）产生CO_2;（FF）超声信号产生;（GG）肿瘤积聚;（HH ）粘合
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公开(公告)号：KR101286059B1
公开(公告)日：2013-07-23
申请号：KR1020110053409
申请日：2011-06-02
Applicant: 한국과학기술연구원
Abstract: 빛의 조사에 의하여 단일항 산소를 발생시키는 유기 광감작제와 효율적인 광감작 작용을 가능하게 하는 무거운 원자가 고밀도로 집적된 코어와, 이 코어를 둘러싸고 있는 계면 활성제 및 물을 포함하는 수계 분산 근적외 광감작제 유기 나노 입자와 그 제조 방법 및 광역학 치료에의 용도가 기재되어 있으며, 상기 제조 방법은, (1) (a) 유기 광작제와 무거운 원자를 포함하는 유기분자 및 계면 활성제를 용매에 용해시켜 균일하게 혼합하고 용매를 제거하는 단계와, (b) 상기 단계 (a)의 생성물에 물을 가하여 나노 입자 수분산액을 제조하는 방법과, (2) (a) 광감작제, 분자 분산제를 유기 용매 내에서 생체 친화성 고분자에 공유결합으로 결합시키고 투석을 통하여 결합되지 않은 분자들을 제거한 다음, 동결 건조하는 단계와, (b) 상기 단계 (a)의 생성물을 음파처리 (sonication)로 물에 분산시키는 단계를 포함하는, 수계 분산 나노 광감작제의 제조 방법을 포함한다.
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