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公开(公告)号：EP2297208A4
公开(公告)日：2012-07-11
申请号：EP09759344
申请日：2009-06-03
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , HAHN ALFRED , MUELLER BERNHARD
CPC classification number: C07K16/2869 , A61K39/3955 , A61K45/06 , A61K47/6843 , A61K47/6845 , A61K47/6849 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/248 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2887 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/525
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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52.发明公开NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NGR) AND USES THEREOF 有权中和单克隆抗体针对NOGO-66受体（NGR）及其用途
公开(公告)号：EP2091563A4
公开(公告)日：2010-12-15
申请号：EP07854735
申请日：2007-11-21
Applicant: ABBOTT LAB
Inventor： MEZLER MARIO , MOELLER ACHIM , MUELLER REINHOLD , MUELLER BERNHARD K , GHAYUR TARIQ , BARLOW EVE H , SCHMIDT MARTIN , MEYER AXEL , TEUSCH NICOLE
IPC: A61K39/395
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , C07H21/00 , C07K16/2863 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
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公开(公告)号：EP2056869A4
公开(公告)日：2009-10-21
申请号：EP07811045
申请日：2007-08-03
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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公开(公告)号：EP1685152A4
公开(公告)日：2008-04-16
申请号：EP04817825
申请日：2004-11-12
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , LABKOVSKY BORIS , VOSS JEFFREY W , GREEN LARRY , BABCOOK JOHN , JIA XIAO-CHI , WIELER JAMES , KANG JASPAL SINGH , HEDBERG BRAD
IPC: C07K16/00 , A61K39/395 , A61P19/02 , A61P37/06 , C07H21/04 , C07K16/24 , C12N15/00 , G01N33/53 , G01N33/68
CPC classification number: G01N33/6869 , A61K2039/505 , C07K16/244 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
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公开(公告)号：SG2014010029A
公开(公告)日：2014-08-28
申请号：SG2014010029
申请日：2006-08-18
Applicant: ABBOTT LAB , ABBOTT LAB
Inventor： WU CHENGBIN , GHAYUR TARIQ , DIXON RICHARD W , SALFELD JOCHEN G
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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Patent Agency Ranking
公开(公告)号：NZ607480A
公开(公告)日：2014-10-31
申请号：NZ60748011
申请日：2011-08-02
Applicant: ABBOTT LAB
Inventor： LIU JUNJIAN , ISAKSON PETER C , GHAYUR TARIQ
IPC: C07K16/00
Abstract: Discloses a binding protein comprising first and second polypeptide chains, each independently comprising VD-(X1)n-VD2-C-(X2)n, wherein the VD1 and VD2 domains form functional binding sites, wherein the functional binding sites bind to IL-1B and are comprised of the following CDR sequences. CDR H1 - RYDMS CDR H2 - YISHGGAGTYYPDSVK CDR H3 - YFDVWGQG CDR L1 - RASGNIHNYLT CDR L2 - NAKTLA CDR L3 - QHFWSIPY
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公开(公告)号：DOP2013000169A
公开(公告)日：2013-12-15
申请号：DO2013000169
申请日：2013-07-23
Applicant: ABBOTT LAB
Inventor： BARDWELL PHILIP , GHAYUR TARIQ
IPC: A61K31/496 , A61K31/635 , A61P19/02
Abstract: La presente invención se relaciona con compuesto N—(4—(4—((4'-cloro(1,1'-bifenil)—2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitrobencensulfonamida y compuesto N—(4—(4—((2—(4-clorofenil)—5, 5-dimetil-1-ciclohex-1-en-1-il)metil)piperazin-1-il)benzoil)-4- (((1R)-3-(morfolin-4-il)-1 -((fenilsulfanil)metil)propil)amino)-3-((trifluorometil) sulfonil) bencensulfonamida para uso en el tratamiento de la artritis en un mamífero.
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公开(公告)号：CO6801630A2
公开(公告)日：2013-11-29
申请号：CO13131677
申请日：2013-05-29
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , LIU JUNJIAN , GU JIJIE , HARRIS MARIA
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公开(公告)号：CL2012000957A1
公开(公告)日：2013-09-06
申请号：CL2012000957
申请日：2012-04-13
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , KAMATH RAJESH V , HONORE MARIE P
IPC: A61K39/395 , A61K51/00 , C07H21/04 , C12N1/21
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公开(公告)号：SG191639A1
公开(公告)日：2013-07-31
申请号：SG2013042916
申请日：2009-06-03
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , ISAKSON PETER C , OLSON LISA M , WU CHENGBIN , HUGUNIN MARGARET , KAMATH RAJESH V , CUFF CAROLYN A , ALLEN HAMISH J
Abstract: DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF AbstractThe present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. Figure 1
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