公开(公告)号：DE60011895T2

公开(公告)日：2005-08-04

申请号：DE60011895

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  DAANEN JEROME F ,  RYTHER KEITH B ,  JI JIANGUO

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：CA2538789A1

公开(公告)日：2005-03-31

申请号：CA2538789

申请日：2004-09-17

Applicant: ABBOTT LAB

Inventor： JI JIANGUO ,  SCHRIMPF MICHAEL R ,  NERSESIAN DIANA L ,  MORTELL KATHLEEN H ,  RYTHER KEITH B ,  PACE JENNIFER M ,  TIETJE KARIN R ,  BUNNELLE WILLIAM H ,  DART MICHAEL J ,  GALLAGHER MEGAN E ,  BASHA ANWER ,  LI TAO

IPC: C07D471/04 ,  A61K31/435 ,  A61P25/00 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

Abstract: Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4- (methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by .alpha.7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I ) and methods for using such compounds and compositions.

公开(公告)号：SI1178982T1

公开(公告)日：2004-12-31

申请号：SI200030480

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  DAANEN JEROME F ,  RYTHER KEITH B ,  JI JIANGUO

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：DK1178982T3

公开(公告)日：2004-11-08

申请号：DK00932445

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： DAANEN JEROME F ,  SIPPY KEVIN B ,  RYTHER KEITH B ,  JI JIANGUO ,  SCHRIMPF MICHAEL R

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：PT1147112E

公开(公告)日：2004-03-31

申请号：PT00906998

申请日：2000-01-25

Applicant: ABBOTT LAB

Inventor： DART MICHAEL J ,  RYTHER KEITH B ,  DAANEN JEROME F ,  BUNNELLE WILLIAM H ,  CRISTINA DANIELA BARLOCCO ,  MEYER MICHEL D ,  SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  TOUPENCE RICHARD B

IPC: A61K31/00 ,  A61K31/407 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D401/08 ,  C07D471/08 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/395

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：PT970083E

公开(公告)日：2003-09-30

申请号：PT98907359

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： RYTHER KEITH B ,  WASICAK JAMES T ,  LIN NAN-HORNG ,  GARVEY DAVID S ,  HOLLADAY MARK W

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：PL352066A1

公开(公告)日：2003-07-28

申请号：PL35206600

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  DAANEN JEROME F ,  RYTHER KEITH B ,  JI JIANGUO

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

公开(公告)号：PT950057E

公开(公告)日：2003-04-30

申请号：PT97952392

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  BAI HAO ,  DART MICHAEL J ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P ,  ARNERIC STEPHEN P ,  LIN NAN-HORNG

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：ZA200109162B

公开(公告)日：2003-02-06

申请号：ZA200109162

申请日：2001-11-06

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  DAANEN JEROME F ,  RYTHER KEITH B ,  JI JIANGUO

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101 ,  C07D ,  A61K ,  A61P

公开(公告)号：HK1045305A1

公开(公告)日：2002-11-22

申请号：HK02105306

申请日：2002-07-17

Applicant: ABBOTT LAB

Inventor： SCHRIMPF MICHAEL R ,  SIPPY KEVIN B ,  DAANEN JEROME F ,  RYTHER KEITH B ,  JI JIANGUO

IPC: C07D491/048 ,  A61K31/00 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4545 ,  A61K45/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  C07D401/04 ,  C07D495/04 ,  C07D ,  A61K ,  A61P

Abstract: Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.